anti-Mouse (Murine) SOS1 antibody for Immunoprecipitation

Recommended SOS1 Antibody (supplied by: Log in to see )

Antigen
Son of Sevenless Homolog 1 (Drosophila) (SOS1) Antibodies
  • GF1
  • GGF1
  • GINGF
  • HGF
  • NS4
  • 4430401P03Rik
  • 9630010N06
  • AI449023
  • SOS Ras/Rac guanine nucleotide exchange factor 1
  • son of sevenless homolog 1 (Drosophila)
  • SOS1
  • Sos1
Epitope
AA 1-109
3
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
52
33
12
8
7
7
7
6
5
4
3
3
1
1
Host
Mouse
32
22
6
Clonality
Monoclonal
Conjugate
This SOS1 antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
44
21
20
13
7
5
2
1
1
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Pubmed
5 references available

Available images

Western Blotting (WB) image for anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) (AA 1-109) antibody (ABIN967740)
Catalog No. ABIN967740
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN967741 IF IP IHC WB Mouse IgG1 AA 1-109 Log in to see 25-SOS1 5
1 ABIN210638 IP WB Rabbit IgG AA 1243-1258 Log in to see Polyclonal 0
1 ABIN2364688 IP WB Rabbit IgG AA 1243-1258 Log in to see Polyclonal 0
1 ABIN1937311 IP Rabbit IgG AA 1025-1075 Log in to see Polyclonal 0
1 ABIN1937312 IP WB Rabbit IgG AA 1283-1333 Log in to see Polyclonal 0

General

Antigen Son of Sevenless Homolog 1 (Drosophila) (SOS1) Antibodies
Epitope AA 1-109
(3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(52), (33), (12), (8), (7), (7), (7), (6), (5), (4), (3), (3), (1), (1)
Host Mouse
(32), (22), (6)
Clonality (Clone)
Monoclonal   ( )
Conjugate This SOS1 antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(44), (21), (20), (13), (7), (5), (2), (1), (1)
Pubmed 5 references available
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Product Details anti-SOS1 Antibody

Target Details SOS1 Application Details Handling References for anti-SOS1 antibody (ABIN967740) Images
Cross-Reactivity Human, Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Mouse mSos1 aa. 1-109
Clone 25-SOS1
Isotype IgG1

Target Details SOS1

Product Details anti-SOS1 Antibody Application Details Handling References for anti-SOS1 antibody (ABIN967740) Images back to top
Antigen
Alternative Name Sos1 (SOS1 Antibody Abstract)
Background The Sos (son of sevenless) gene was originally identified in Drosophila, and two mammalian homologues (mSos1 and mSos2) were isolated from a mouse cDNA library. These two cDNAs predict proteins that are approximately 70% identical in their amino acid residues. Both mSos1 and mSos2 are expressed in a wide number of mouse embryonic and adult tissues as well as in several cell lines. The human homologues, hSos1 and hSos2 have also been isolated and show a very high degree of amino acid identity to the mouse genes (98% for Sos1). Sos1 has a predicted molecular weight of 150kDa, but the apparent molecular weight is closer to 170 kDa, presumably due to a high proline content. The mammalian Sos1 protein has a highly specific guanine nucleotide exchange activity toward p21ras . In EGF-stimulated cells, Sos1 interacts with the SH3 domains of GRB2, and GRB2 binds via its SH2 domain to tyrosine 1068 of the activated EGF receptor. Thus, GRB2 recruits Sos1 to the plasma membrane and enables it to activate the Ras signaling pathway by enhancing GTP loading on p21ras .
Molecular Weight 170 kDa
Pathways RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor

Application Details

Product Details anti-SOS1 Antibody Target Details SOS1 Handling References for anti-SOS1 antibody (ABIN967740) Images back to top
Comment

Related Products: ABIN968539, ABIN967389
Restrictions For Research Use only

Handling

Product Details anti-SOS1 Antibody Target Details SOS1 Application Details References for anti-SOS1 antibody (ABIN967740) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References for anti-SOS1 antibody (ABIN967740)

Product Details anti-SOS1 Antibody Target Details SOS1 Application Details Handling Images back to top
Product cited in:

Furuta, Miura, Copeland, Shang, Oshima, Kamata: "Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling." in: Oncogene, Vol. 21, Issue 46, pp. 7060-6, 2002

Kardinal, Konkol, Lin, Eulitz, Schmidt, Estrov, Talpaz, Arlinghaus, Feller: "Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes." in: Blood, Vol. 98, Issue 6, pp. 1773-81, 2001

Salojin, Zhang, Meagher, Delovitch: "ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5966-75, 2000

Buday, Downward: "Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor." in: Cell, Vol. 73, Issue 3, pp. 611-20, 1993

Egan, Giddings, Brooks, Buday, Sizeland, Weinberg: "Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation." in: Nature, Vol. 363, Issue 6424, pp. 45-51, 1993

Images

Product Details anti-SOS1 Antibody Target Details SOS1 Application Details Handling References for anti-SOS1 antibody (ABIN967740) back to top
Supplier Images
Western Blotting (WB) image for anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) (AA 1-109) antibody (ABIN967740) Western blot analysis of Sos1 on PC12 lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1...