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SOS1 Products

(Son of Sevenless Homolog 1 (SOS1))

Categories

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008].

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Featured SOS1 Categories

SOS1 Antibodies

High quality antibodies with extensive validation data.

SOS1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SOS1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IF, IHC, WB
Validations
  • (4)
Cat. No. ABIN7170318
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application PLA, ELISA
Validations
  • (4)
Cat. No. ABIN520376
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application EIA, IF, WB
Validations
  • (3)
Cat. No. ABIN238504
Quantity 0.1 mg
Datasheet Datasheet

Recommended SOS1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970366
Quantity 96 tests
Datasheet Datasheet

Recommended SOS1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095504
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135535
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1320973
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our SOS1 products

Harris, Parry, Westwick, Ward: "Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes." in: The Journal of biological chemistry, Vol. 283, Issue 5, pp. 2465-9, (2008) (PubMed).

Bernards, Settleman: "GEFs in growth factor signaling." in: Growth factors (Chur, Switzerland), Vol. 25, Issue 5, pp. 355-61, (2008) (PubMed).

McDonald, Seldeen, Deegan, Farooq: "Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine nucleotide exchange factor Sos1." in: Archives of biochemistry and biophysics, Vol. 479, Issue 1, pp. 52-62, (2008) (PubMed).

Xing, Hamaguchi: "Effects of SHIP-1 on MMP2 secretion and invasion of SR3Y1 cells." in: Journal of genetics and genomics = Yi chuan xue bao, Vol. 34, Issue 4, pp. 285-93, (2007) (PubMed).

Tarasenko, Kole, Chi, Mentink-Kane, Wynn, Bolland: "T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 27, pp. 11382-7, (2007) (PubMed).

Furuta, Miura, Copeland, Shang, Oshima, Kamata: "Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling." in: Oncogene, Vol. 21, Issue 46, pp. 7060-6, (2002) (PubMed).

Kardinal, Konkol, Lin, Eulitz, Schmidt, Estrov, Talpaz, Arlinghaus, Feller: "Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes." in: Blood, Vol. 98, Issue 6, pp. 1773-81, (2001) (PubMed).

Salojin, Zhang, Meagher, Delovitch: "ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5966-75, (2000) (PubMed).

Scita, Tenca, Frittoli, Tocchetti, Innocenti, Giardina, Di Fiore: "Signaling from Ras to Rac and beyond: not just a matter of GEFs." in: The EMBO journal, Vol. 19, Issue 11, pp. 2393-8, (2000) (PubMed).

Buday, Downward: "Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor." in: Cell, Vol. 73, Issue 3, pp. 611-20, (1993) (PubMed).

Synonyms and alternative names related to SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1 (SOS1), son of sevenless homolog 1 (Drosophila) (Sos1), SOS Ras/Rac guanine nucleotide exchange factor 1 (Sos1), 4430401P03Rik, 9630010N06, AI449023, GF1, GGF1, GINGF, HGF, NS4

Protein level used designations for SOS1

  • SOS-1
  • gingival fibromatosis, hereditary, 1
  • guanine nucleotide exchange factor
  • son of sevenless homolog 1
  • guanine nucleotide releasing factor
  • ras guanine exchange factor
  • son-of-sevenless 1
  • Son of sevenless homolog 1
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