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we developed RgIA4, a peptide that exhibits high potency for both human and rodent a9a10 nAChRs, and was at least 1,000-fold more selective for a9a10 nAChRs vs. all other molecular targets tested, including opioid and GABAB receptors
Results demonstrate that alpha9(-/-) and alpha10(-/-) mice have overlapping but nonidentical phenotypes.
Multiple features of the efferent postsynaptic complex to inner hair cells, in addition to the alpha9alpha10 nicotinic cholinergic receptors, are down-regulated in synchrony after the onset of hearing, leading to lack of responses to acetylcholine.
Co-expression of the alpha10 subunit converts the normally weak acetylcholine-mediated activity of alpha9 to a more robustly active channel with identical physiological characteristics of the native mammalian outer hair cell cholinergic receptor.
A two order of magnitude species difference is reported in potency of alpha-conotoxin RgIA for rat versus human alpha9alpha10 nAChR.
CHRNA10 may have a role in "dizziness" in response to tobacco
alpha10 subunit of the nicotininc acetylcholine receptor (nAChR); may heterodimerize with alpha9 subunit
neuronal acetylcholine receptor subunit alpha-10
, NACHR alpha-10
, acetylcholine receptor, nicotinic, alpha 10 (neuronal)
, cholinergic receptor, nicotinic, alpha polypeptide 10
, nicotinic acetylcholine receptor subunit alpha-10
, NACHR alpha 10
, neuronal nicotinic acetylcholine receptor subunit
, nicotinic acetylcholine receptor subunit alpha 10
, cholinergic receptor, nicotinic, alpha 10
, neuronal acetylcholine receptor subunit alpha-10-like
, alpha 10 subunit of nicotinic acetylcholine receptor