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SKP2 Products

(S-Phase Kinase-Associated Protein 2 (SKP2))

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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class\; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011].

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Featured SKP2 Categories

SKP2 Antibodies

High quality antibodies with extensive validation data.

SKP2 ELISA Kits

Reliable ELISA kits for a wide range of species.

SKP2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SKP2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (4)
  • (5)
Cat. No. ABIN737601
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, ICC, IF, IHC, WB
Validations
  • (1)
  • (4)
Cat. No. ABIN6265105
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, IHC, ELISA, WB
Validations
  • (3)
Cat. No. ABIN1533399
Quantity 100 μg
Datasheet Datasheet

Recommended SKP2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970239
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959502
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381499
Quantity 96 tests
Datasheet Datasheet

Recommended SKP2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2732125
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095574
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3120254
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SKP2 products

Zhang, Miao, Li, Cui, Ge, Chen: "S-phase kinase-associated protein 2 impairs the inhibitory effects of miR-1236-3p on bladder tumors." in: American journal of translational research, Vol. 10, Issue 3, pp. 731-743, (2018) (PubMed).

Li, Wei, Hu, Zhang, Li, Wan, Zhang, Yao: "Upregulation of Cdh1 Attenuates Isoflurane-Induced Neuronal Apoptosis and Long-Term Cognitive Impairments in Developing Rats." in: Frontiers in cellular neuroscience, Vol. 11, pp. 368, (2017) (PubMed).

Pan, Li, Zhong, Chen, Chen, Gao, Wu, Guo: "RIG-I inhibits pancreatic β cell proliferation through competitive binding of activated Src." in: Scientific reports, Vol. 6, pp. 28914, (2016) (PubMed).

Wen, Wang, Yang: "Inhibiting the role of Skp2 suppresses cell proliferation and tumorigenesis of human gastric cancer cells via the upregulation of p27kip1." in: Molecular medicine reports, Vol. 14, Issue 4, pp. 3917-24, (2016) (PubMed).

Bhatt, Stender, Joshi, Wu, Katzenellenbogen: "OCT-4: a novel estrogen receptor-α collaborator that promotes tamoxifen resistance in breast cancer cells." in: Oncogene, Vol. 35, Issue 44, pp. 5722-5734, (2016) (PubMed).

Yang, Wang, Wang, Zhang, Zhang, Lu, Wang: "mTOR is involved in 17?-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1." in: Molecular reproduction and development, Vol. 82, Issue 4, pp. 305-14, (2015) (PubMed).

Jiao, Yi, Rong, Kee, Zhong: "MicroRNA-1285 regulates 17?-estradiol-inhibited immature boar Sertoli cell proliferation via adenosine monophosphate-activated protein kinase activation." in: Endocrinology, pp. en20141982, (2015) (PubMed).

Sun, Yang, Luo, Wang, Chen, Zhang, Wang, Li: "Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway." in: Theriogenology, (2014) (PubMed).

Xu, Zhu, Han, You, Liu, Ye, Zhang, Wang, Yao: "The oncoprotein hepatitis B X-interacting protein promotes the migration of ovarian cancer cells through the upregulation of S-phase kinase-associated protein 2 by Sp1." in: International journal of oncology, Vol. 45, Issue 1, pp. 255-63, (2014) (PubMed).

Chen, Xie, Zhao, Wang, Bai, Yin, Jiang, Xie, Jia, Huang et al.: "Ampelopsin induces apoptosis by regulating multiple c?Myc/S?phase kinase?associated protein 2/F?box and WD repeat?containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma ..." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 105-12, (2014) (PubMed).

Synonyms and alternative names related to SKP2

S-phase kinase-associated protein 2 (p45) (Skp2), S-phase kinase associated protein 2 (SKP2), S-phase kinase associated protein 2 (Skp2), FBL1, FBXL1, FLB1, p45, RGD1562456

Protein level used designations for SKP2

  • F-box protein Skp2
  • F-box/WD-40 protein 1
  • FWD1
  • S-phase kinase-associated protein 2
  • cyclin A/CDK2-associated protein p45
  • cyclin-A/CDK2-associated protein p45
  • p45
  • CDK2/cyclin A-associated protein p45
  • F-box/LRR-repeat protein 1
  • S-phase kinase-associated protein 2 (p45)
  • p45skp2
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