anti-Human CBL antibody for Immunohistochemistry

Recommended CBL Antibody (supplied by: Log in to see )

Antigen
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies
  • 4732447J05Rik
  • Cbl-2
  • c-Cbl
  • cbl
  • C-CBL
  • CBL2
  • FRA11B
  • NSLL
  • RNF55
  • c-cbl-like
  • RGD1561386
  • Casitas B-lineage lymphoma
  • Cbl proto-oncogene
  • Cbl
  • CBL
Epitope
AA 698-702
50
40
32
30
21
6
5
5
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
307
198
177
5
4
4
4
3
3
1
1
1
Host
Rabbit
260
36
17
1
Clonality
Polyclonal
Conjugate
This CBL antibody is un-conjugated
8
8
8
7
6
6
5
5
5
5
5
5
5
5
5
4
2
2
1
Application
Immunohistochemistry (IHC)
220
104
100
65
62
50
20
18
15
11
5
3
3
3
1
1
Options
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Catalog No. ABIN658935
$ 475.29
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
8.59322 ABIN2704545 IC IF IHC WB Rabbit C-Term, pTyr700 Log in to see Polyclonal 0
8.59322 ABIN2704546 IC IF IHC WB Rabbit C-Term, pTyr774 Log in to see Polyclonal 0
8.59322 ABIN2705618 IHC WB Rabbit pTyr674 Log in to see Polyclonal 0
8.59322 ABIN1531307 IF IHC ELISA WB Rabbit IgG AA 666-715, pTyr700 Log in to see Polyclonal 1
8.59322 ABIN4880224 ELISA FACS ICC IHC WB Mouse IgG1 Log in to see 3B12 0
8.59322 ABIN1845278 ELISA FACS IF/ICC IHC WB Mouse IgG1 Log in to see 0
8.59322 ABIN1531306 IF IHC ELISA WB Rabbit IgG AA 740-789, pTyr774 Log in to see Polyclonal 0
8.59322 ABIN1532327 IHC ELISA WB Rabbit IgG AA 640-689 Log in to see Polyclonal 0
8.59322 ABIN1531308 IHC ELISA WB Rabbit IgG AA 640-689, pTyr674 Log in to see Polyclonal 0
8.59322 ABIN1532326 IF IHC ELISA WB Rabbit IgG AA 666-715 Log in to see Polyclonal 0
8.59322 ABIN1532325 IF IHC ELISA WB Rabbit IgG AA 740-789 Log in to see Polyclonal 0
8.59322 ABIN968993 ICC FACS IHC ELISA WB Mouse IgG1 Log in to see 3B12 3
8.59322 ABIN2736434 IHC WB Rabbit IgG Log in to see Polyclonal 0
8.59322 ABIN658936 IF IHC WB Rabbit IgG pTyr770 Log in to see Polyclonal 0
8.59322 ABIN4288401 ELISA FACS ICC IF IHC WB Mouse IgG1 Log in to see 3B12 0
8.59322 ABIN1870034 IF IHC WB Rabbit IgG pTyr700 Log in to see Polyclonal 0
8.59322 ABIN6256785 ELISA ICC IF IHC WB Rabbit IgG pTyr674 Log in to see Polyclonal 0
8.59322 ABIN6269939 ELISA IHC WB Rabbit IgG pSer804 Log in to see Polyclonal 0
8.59322 ABIN2470040 IP IHC WB Rabbit IgG C-Term Log in to see Polyclonal 0
8.59322 ABIN6255990 IHC WB Rabbit IgG pTyr700 Log in to see Polyclonal 0

General

Antigen Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies
Epitope AA 698-702
(50), (40), (32), (30), (21), (6), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(307), (198), (177), (5), (4), (4), (4), (3), (3), (1), (1), (1)
Host Rabbit
(260), (36), (17), (1)
Clonality
Polyclonal
Conjugate This CBL antibody is un-conjugated
(8), (8), (8), (7), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (2), (2), (1)
Application Immunohistochemistry (IHC)
(220), (104), (100), (65), (62), (50), (20), (18), (15), (11), (5), (3), (3), (3), (1), (1)
Pubmed 5 references available
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Product Details anti-CBL Antibody

Target Details CBL Application Details Handling References for anti-CBL antibody (ABIN658935) Images
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen Peptide sequence around aa. 698~702 (T-E-Y-M-T), according to the protein NP_005179.2
Isotype IgG
Plasmids, Primers & others

Target Details CBL

Product Details anti-CBL Antibody Application Details Handling References for anti-CBL antibody (ABIN658935) Images back to top
Antigen
Alternative Name CBL (CBL Antibody Abstract)
Background E3 ubiquitin-protein ligase CBL, 632-, Casitas B-lineage lymphoma proto-oncogene, Proto-oncogene c-Cbl, RING finger protein 55, Signal transduction protein CBL, CBL, CBL2, RNF55
Molecular Weight 99633 Da
Gene ID 867
NCBI Accession NP_005179
UniProt P22681
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals

Application Details

Product Details anti-CBL Antibody Target Details CBL Handling References for anti-CBL antibody (ABIN658935) Images back to top
Application Notes The suggested dilution is: IHC: 1:50-1:100
Restrictions For Research Use only

Handling

Product Details anti-CBL Antibody Target Details CBL Application Details References for anti-CBL antibody (ABIN658935) Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months

References for anti-CBL antibody (ABIN658935)

Product Details anti-CBL Antibody Target Details CBL Application Details Handling Images back to top
Background publications

Niemeyer, Kang, Shin, Furlan, Erlacher, Bunin, Bunda, Finklestein, Sakamoto, Gorr, Mehta, Schmid, Kropshofer, Corbacioglu, Lang, Klein, Schlegel, Heinzmann, Schneider, Starý, van den Heuvel-Eibrink et al.: "Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. ..." in: Nature genetics, Vol. 42, Issue 9, pp. 794-800, 2010

Rocquain, Carbuccia, Trouplin, Raynaud, Murati, Nezri, Tadrist, Olschwang, Vey, Birnbaum, Gelsi-Boyer, Mozziconacci: "Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias." in: BMC cancer, Vol. 10, pp. 401, 2010

Martinelli, De Luca, Stellacci, Rossi, Checquolo, Lepri, Caputo, Silvano, Buscherini, Consoli, Ferrara, Digilio, Cavaliere, van Hagen, Zampino, van der Burgt, Ferrero, Mazzanti, Screpanti, Yntema et al.: "Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype. ..." in: American journal of human genetics, Vol. 87, Issue 2, pp. 250-7, 2010

Matsuda, Taira, Sakashita, Saito, Tanaka-Yanagisawa, Yanagisawa, Nakazawa, Shiohara, Fukushima, Oda, Honda, Nakahata, Koike: "Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations." in: Blood, Vol. 115, Issue 26, pp. 5429-31, 2010

Ye, Cihil, Stolz, Pilewski, Stanton, Swiatecka-Urban: "c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27008-18, 2010

Images

Product Details anti-CBL Antibody Target Details CBL Application Details Handling References for anti-CBL antibody (ABIN658935) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (AA 698-702) antibody (ABIN658935) Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using...