Get this product for free
Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
---|---|---|---|---|---|---|---|---|---|---|
24.85835 | ABIN4880224 | ELISA FACS ICC IHC WB | Mouse | IgG1 | Log in to see | 3B12 | 0 | |||
24.85835 | ABIN1845278 | ELISA FACS IF/ICC IHC WB | Mouse | IgG1 | Log in to see | 0 | ||||
12.858351 | ABIN6390851 | FACS | Rabbit | IgG1 kappa | pTyr700 | Log in to see | CblY700-E1 | 0 | ||
12.38187 | ABIN4901147 | ELISA FACS IF IHC (p) WB | Mouse | IgG1 | Log in to see | 3B12 | 0 | |||
10.918978 | ABIN4288401 | ELISA FACS ICC IF IHC WB | Mouse | IgG1 | Log in to see | 3B12 | 0 | |||
9.858351 | ABIN6390855 | FACS | PE | Rabbit | IgG1 kappa | pTyr700 | Log in to see | CblY700-E1 | 0 | |
9.858351 | ABIN6390853 | FACS | APC | Rabbit | IgG1 kappa | pTyr700 | Log in to see | CblY700-E1 | 0 | |
9.858351 | ABIN6390857 | FACS | SureLight 488® | Rabbit | IgG1 kappa | pTyr700 | Log in to see | CblY700-E1 | 0 | |
4 | ABIN2590840 | ELISA FACS IF IHC IHC (p) WB | Mouse | IgG1 | Log in to see | 3B12 | 0 | |||
4 | ABIN2665478 | FACS | Rabbit | Log in to see | Polyclonal | 1 |
General |
|
---|---|
Antigen | Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies |
Reactivity | Human, Mouse (Murine), Rat (Rattus) Alternatives |
Host | Mouse Alternatives |
Clonality (Clone) | |
Conjugate | This CBL antibody is un-conjugated Alternatives |
Application |
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
Alternatives
|
![]() |
3 references available |
Supplier | Log in to see |
Product Details anti-CBL AntibodyTarget Details CBL Application Details Handling References for anti-CBL antibody (ABIN968993) Images |
|
Purification | Ascites |
Immunogen | Purified recombinant fragment of human C-CBL expressed in E. Coli. |
Clone | 3B12 |
Isotype | IgG1 |
Plasmids, Primers & others | |
Target Details CBLProduct Details anti-CBL Antibody Application Details Handling References for anti-CBL antibody (ABIN968993) Images back to top |
|
Antigen | |
Alternative Name | C-CBL (CBL Antibody Abstract) |
Background | The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. |
Molecular Weight | 120 kDa |
Gene ID | 867 |
HGNC | 867 |
Pathways | TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals |
Application DetailsProduct Details anti-CBL Antibody Target Details CBL Handling References for anti-CBL antibody (ABIN968993) Images back to top |
|
Application Notes | ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400 |
Restrictions | For Research Use only |
HandlingProduct Details anti-CBL Antibody Target Details CBL Application Details References for anti-CBL antibody (ABIN968993) Images back to top |
|
Format | Liquid |
Buffer | Ascitic fluid containing 0.03 % sodium azide. |
Preservative | Sodium azide |
Precaution of Use | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | 4 °C,-20 °C |
Storage Comment | 4°C, -20°C for long term storage |
References for anti-CBL antibody (ABIN968993)Product Details anti-CBL Antibody Target Details CBL Application Details Handling Images back to top |
|
Product cited in: |
Sproul, Xu, Wilhelm, Gire, Greene: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, 2009 Sanada, Suzuki, Shih, Otsu, Kato, Yamazaki, Tamura, Honda, Sakata-Yanagimoto, Kumano, Oda, Yamagata, Takita, Gotoh, Nakazaki, Kawamata, Onodera, Nobuyoshi, Hayashi, Harada, Kurokawa, Chiba, Mori et al.: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. ..." in: Nature, Vol. 460, Issue 7257, pp. 904-8, 2009 Loh, Sakai, Flotho, Kang, Fliegauf, Archambeault, Mullighan, Chen, Bergstraesser, Bueso-Ramos, Emanuel, Hasle, Issa, van den Heuvel-Eibrink, Locatelli, Stary, Trebo, Wlodarski, Zecca, Shannon et al.: "Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. ..." in: Blood, Vol. 114, Issue 9, pp. 1859-63, 2009 |
ImagesProduct Details anti-CBL Antibody Target Details CBL Application Details Handling References for anti-CBL antibody (ABIN968993) back to top |
|
Supplier Images |
|