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|Antigen||Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This CBL antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-CBL AntibodyTarget Details CBL Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human C CBL around the phosphorylation site of Tyr674|
Target Details CBLProduct Details anti-CBL Antibody Application Details Handling Images back to top
|Alternative Name||Cbl2 (CBL Antibody Abstract)|
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
Synonyms: C CBL Tyr674, CBL2 Tyr674, CBL2 Y674, p-CBL2 Tyr674, p-CBL2 Y674, C CBL, Cas Br M murine ecotropic retroviral transforming sequence, Cas-Br-M murine ecotropic retroviral transforming sequence, Casitas B lineage lymphoma proto oncogene, Casitas B-lineage lymphoma proto-oncogene, CBL 2, cbl, CBL_HUMAN, CBL2, E3 ubiquitin protein ligase CBL, E3 ubiquitin-protein ligase CBL, Oncogene CBL2, Proto oncogene c CBL, Proto-oncogene c-CBL, RGD1561386, RING finger protein 55, RNF55, Signal transduction protein CBL.
|Pathways||TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals|
Application DetailsProduct Details anti-CBL Antibody Target Details CBL Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-CBL Antibody Target Details CBL Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
ImagesProduct Details anti-CBL Antibody Target Details CBL Application Details Handling back to top