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Elevated expression of RPA3 promotes tumor progression in hepatocellular carcinoma cells.
Up-regulation of RPA3 is involved in gastric cancer tumorigenesis and is associated with poorer patient survival.
RPA, best known for its role in DNA replication and repair, recruits HIRA to promoters and enhancers and regulates deposition of newly synthesized H3.3 to these regulatory elements for gene regulation.
The allele "T" of rs6947203 in the RPA3 gene acts as a protective allele in glioma.
Data indicate taht candidate genes ACTB (show ACTB Proteins), BZW, OCM (show OCM Proteins), MACC1 (show MACC1 Proteins), NXPH1 (show NXPH1 Proteins), PRPS1L1 (show PRPS1L1 Proteins), RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified.
RPA3 interacts directly with ssDNA on the 3'-side on a 31 nt ssDNA.
Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair\; it does not support chromosomal DNA replication and cell cycle progression through S- phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.
RF-A protein 3
, RP-A p14
, replication factor A protein 3
, replication protein A 14 kDa subunit
, replication protein A3, 14kDa