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Human CREB1 Protein expressed in Wheat germ - ABIN1350285
Yin, Li, Yang, Gao, Sun, Li: Detection of CREB phosphorylation via Zr (IV) ion mediated signal amplification. in Biosensors & bioelectronics 2014
CREB is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC.
The sequence of the CREB gene contains a 88 bp 5' UTR, a 783 bp open reading frame encoding 261 amino acids and a 348 bp 3' UTR.
Data indicate increasing expression for CREB, ATF1 (show AFT1 Proteins), and ATF3 (show ATF3 Proteins) during gastrulation.
Study suggest that both p300 (show EP300 Proteins) and CREB are required for the function integrity of HIF-1alpha (show HIF1A Proteins) transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300 (show EP300 Proteins), CREB and HIF-1alpha (show HIF1A Proteins).
These findings suggest that CREB1 may be a potential therapeutic target for the treatment of gastric cancer
YAP (show YAP1 Proteins)/ TAZ (show TAZ Proteins) pathways contribute to the proliferation/quiescence switch during colon cancer 5FU treatment according to the concerted regulation of Cyclin E1 (show CCNE1 Proteins) and CREB
Data demonstrate that CREB is downregulated in glioma cells and is a direct target of miR (show MLXIP Proteins)-433-3p. These findings indicate that CREB subsequently directly or indirectly modulates its target genes to control the cell growth and metastasis in glioma.
these studies demonstrate that transcription factors CREB and c-Myc (show MYC Proteins) maintain the transcriptional activity of STING
GRK3 (show ADRBK2 Proteins) is a new critical activator of neuroendocrine phenotypes and mediator of CREB activation in promoting neuroendocrine differentiation of prostate cancer cells.
miR (show MLXIP Proteins)-150 is a novel Wnt (show WNT2 Proteins) effector that may significantly enhance epithelial-mesenchymal transition of colorectal cancer cells by targeting the CREB signaling pathway
fMRI and genotyping data from a large human sample, together with previous evidence, support the view that CREB1-associated mechanisms modulate brain function and behavior during reward-based decision-making.
Knockdown of either HIF-1 (show HIF1A Proteins) or CREB or both in hypoxia reduced the expression of hypoxia-response elements- and CRE-mediated gene expression, diminished cell proliferation and increased caspase-3 (show CASP3 Proteins) activity.
MnTE-2-PyP (show PPA1 Proteins) decreased p300 (show EP300 Proteins) complex binding to a specific HRE motif within the PAI-1 (show SERPINE1 Proteins) gene promoter region, suppressed H3K9 acetylation, and consequently, repressed PAI-1 (show SERPINE1 Proteins) expression. Mechanistically, less p300 (show EP300 Proteins) transcriptional complex binding is not due to the reduction of binding between p300 (show EP300 Proteins) and HIF-1 (show HIF1A Proteins)/CREB transcription factors, but through inhibiting the binding of HIF-1 (show HIF1A Proteins)/CREB transcription factors to DNA
phosphorylation of CREB is downregulated in the Muller glia.
Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB signaling.
Both CREB and deltaFosB play a role in the induction of this behavioural sensitization.
astrocytic IL-17A (show IL17A Proteins) plays important roles in the maintenance of neuropathic pain through CaMKII (show CAMK2G Proteins)/CREB signaling pathway in spinal cord.
LH induces MAPK3 (show MAPK3 Proteins)/1 and Akt (show AKT1 Proteins) activation, both of which are required for the CREB-promoted expression of EGF (show EGF Proteins)-like factors in granulosa cells.
However, the mechanism that induces release of IL-6 (show IL6 Proteins) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (show IL6 Proteins) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway.
NFIL3 (show NFIL3 Proteins) functions as an important regulator of glucose homeostasis in the liver by limiting CREB-mediated hepatic gluconeogenesis
EGCG significantly ameliorated insulin (show INS Proteins) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1 (show IRS1 Proteins))/AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins)/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF (show BDNF Proteins)) signaling pathways.
Ca(2 (show CA2 Proteins)+) signaling pathway increases Nr4a1 (show NR4A1 Proteins) expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (show MEF2C Proteins), AP1 (show JUN Proteins), and CREB transcription factors thus demonstrating an important interplay between the Ca(2 (show CA2 Proteins)+) and cAMP pathways in regulating Nr4a1 (show NR4A1 Proteins) expression.
PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway.
The expression of porcine Prdx6 (show PRDX6 Proteins) gene is up-regulated by C/EBPbeta (show CEBPB Proteins) and CREB.
Results suggest that cerebral hypoxia results in differential regulation of CREB protein-mediated expression of proapoptotic and antiapoptotic proteins in the cerebral cortex of newborn piglets.
Data indicate that Ser738/742-to-glutamate (show GRIN2A Proteins) protein kinase D (show PRKD1 Proteins) mutant increased AngII-induced CREB protein and activating transcription factor 2 (show ATF2 Proteins) phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein (show STAR Proteins) promoter.
SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia.
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 (show LYPLA1 Proteins)
the p38-MAPK (show MAPK14 Proteins)/CREB pathway plays a critical role in TNFalpha (show TNF Proteins)-induced VCAM-1 (show VCAM1 Proteins) expression
We found several conserved cis elements in the frog CRF genes including a cAMP response element (CRE), activator protein 1 binding sites, and glucocorticoid response elements
p38 MAPK (show MAPK14 Proteins) and CREB function along the dorsal-ventral axis in mesoderm patterning. The phosphorylated form of CREB (S133) is distributed in a gradient along the dorsal-ventral mesoderm axis and the p38 MAPK (show MAPK14 Proteins) pathway mediates the phosphorylation of CREB.
modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
cAMP responsive element binding protein 1
, cAMP responsive element binding protein
, cyclic AMP-responsive element-binding protein 1
, active transcription factor CREB
, cAMP-response element-binding protein-1
, cAMP-responsive element-binding protein 1
, transactivator protein
, Y protein
, cAMP response element binding protein 1
, cAMP response element-binding protein
, cyclic AMP-responsive element binding protein, delta
, cyclic AMP-responsive DNA-binding protein