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Human CREB1 Protein expressed in Wheat germ - ABIN1350285
Yin, Li, Yang, Gao, Sun, Li: Detection of CREB phosphorylation via Zr (IV) ion mediated signal amplification. in Biosensors & bioelectronics 2014
CREB is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC.
The sequence of the CREB gene contains a 88 bp 5' UTR, a 783 bp open reading frame encoding 261 amino acids and a 348 bp 3' UTR.
Data indicate increasing expression for CREB, ATF1 (show AFT1 Proteins), and ATF3 (show ATF3 Proteins) during gastrulation.
CREB1 may activate the transcription of wtBRAF through directly binding to its promoter, increasing BRAF (show BRAF Proteins) expression and regulating the cell proliferation, migration and invasion of endometriosis.
to explore genetic variations in CREB1 promoter region and determine whether these loci affect transcriptional activity and risk on type 2 diabetes (T2D). Three polymorphisms were identified and designated as MU1, MU2 (show AP2M1 Proteins) and MU3 (show COMMD7 Proteins), respectively. Genotypic distribution analysis revealed that MU1 genotypes presented similar distribution between T2D and healthy controls (P>0.05)
experiments mainly reveal that the CREB1 could affect glucose transport in glioma cells by regulating the expression of GLUT1 (show SLC2A1 Proteins), which controlled the metabolism of glioma and affected the progression of glioma.
These data highlight a novel arrestin (show SAG Proteins)-mediated modulation of CREB signalling, suggesting a reciprocal relationship between arrestin2 and arrestin3, wherein recruitment of arrestin3 restricts the ability of beta2AR (show ADRB2 Proteins) to activate prolonged CREB phosphorylation by precluding recruitment of an arrestin2/Src (show SRC Proteins)/p38 (show CRK Proteins) complex.
The authors conclude that taurodeoxycholic acid-induced DNA damage may depend on the activation of TGR5 (show GPBAR1 Proteins), CREB and NOX5 (show NOX5 Proteins)-S. It is possible that in Barrett's patients bile acids may activate NOX5 (show NOX5 Proteins)-S and increase reactive oxygen species (ROS (show ROS1 Proteins)) production via activation of TGR5 (show GPBAR1 Proteins) and CREB. NOX5 (show NOX5 Proteins)-S-derived ROS (show ROS1 Proteins) may cause DNA damage, thereby contributing to the progression from Barrett's esophagus to esophageal adenocarcinoma.
The mechanism of CBP (show CREBBP Proteins)-CREB association via their pKID/KIX domains studied by molecular dynamics free energy simulations has been reported.
Results indicate CREB1 as a critical transcription factor of RRM2 (show RRM2 Proteins) which promotes tumor aggressiveness, and imply a significant correlation between CREB1 and RRM2 (show RRM2 Proteins) in CRC (show CALR Proteins) specimens.
Study suggest that both p300 (show EP300 Proteins) and CREB are required for the function integrity of HIF-1alpha (show HIF1A Proteins) transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300 (show EP300 Proteins), CREB and HIF-1alpha (show HIF1A Proteins).
These findings suggest that CREB1 may be a potential therapeutic target for the treatment of gastric cancer
YAP (show YAP1 Proteins)/ TAZ (show TAZ Proteins) pathways contribute to the proliferation/quiescence switch during colon cancer 5FU treatment according to the concerted regulation of Cyclin E1 (show CCNE1 Proteins) and CREB
Unexpectedly, although dispensable for FOXP3 (show FOXP3 Proteins) expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-beta (show TGFB1 Proteins)-induced Treg cells, and deletion of CREB resulted in increased FOXP3 (show FOXP3 Proteins)+ Treg cells in the intestine and protection in a colitis model
The absence of gut (show GUSB Proteins) microbiota from birth was shown to be associated with decreased CREB expression, followed by decreases of protein kinase C beta (PRKCB (show PRKCB Proteins)) and AMPA (show GRIA3 Proteins) receptors expression, and an increase of phosphorylation CREB (pCREB) expression.
Findings suggest that cAMP response element binding protein -mediated hippoacampus structural plasticity is crucial for the role of 5-HT1a receptor (show CC2D1A Proteins) in modulating anxiety-related behaviors.
Significant CREB activation in almost the whole amygdala and hippocampus was observed after unconditioned stimulus-retrieval, but conditioned stimulus-retrieval only stimulated CREB activation in the lateral amygdala and the CA3 (show CA3 Proteins) of hippocampus. In addition, propranolol, a beta (show SUCLA2 Proteins)-adrenergic receptor antagonist, treatment suppressed memory retrieval-induced CREB activation.
Curc-mPEG454 reverses HFD-induced hepatic steatosis via the activation of CREB inhibition.
Neuron-specific, adult-deletion of CREB1 alters hippocampal structures and causes neuropathological changes resembling aging brain.
analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes
the requirement of Creb1 for normal mammalian lung morphogenesis is not dependent upon its expression in lung epithelium or mesenchyme, nor its role in musculoskeletal development.
data provide persuasive evidence towards the distinct roles of CREB within the dorsal and ventral hippocampus separately in mediating select nicotine withdrawal phenotypes.
phosphorylation of CREB is downregulated in the Muller glia.
Data indicate that Ser738/742-to-glutamate (show GRIN2A Proteins) protein kinase D (show PRKD1 Proteins) mutant increased AngII-induced CREB protein and activating transcription factor 2 (show ATF2 Proteins) phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein (show STAR Proteins) promoter.
SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia.
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 (show LYPLA1 Proteins)
the p38-MAPK (show MAPK14 Proteins)/CREB pathway plays a critical role in TNFalpha (show TNF Proteins)-induced VCAM-1 (show VCAM1 Proteins) expression
We found several conserved cis elements in the frog CRF genes including a cAMP response element (CRE), activator protein 1 binding sites, and glucocorticoid response elements
p38 MAPK (show MAPK14 Proteins) and CREB function along the dorsal-ventral axis in mesoderm patterning. The phosphorylated form of CREB (S133) is distributed in a gradient along the dorsal-ventral mesoderm axis and the p38 MAPK (show MAPK14 Proteins) pathway mediates the phosphorylation of CREB.
modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
cAMP responsive element binding protein 1
, cAMP responsive element binding protein
, cyclic AMP-responsive element-binding protein 1
, active transcription factor CREB
, cAMP-response element-binding protein-1
, cAMP-responsive element-binding protein 1
, transactivator protein
, Y protein
, cAMP response element binding protein 1
, cAMP response element-binding protein
, cyclic AMP-responsive element binding protein, delta
, cyclic AMP-responsive DNA-binding protein