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Mouse (Murine) FTH1 Protein expressed in Escherichia coli (E. coli) - ABIN1079501
Inokura, Fujiwara, Saito, Iino, Hatta, Okitsu, Fukuhara, Onishi, Ishizawa, Shimoda, Harigae: Impact of TET2 deficiency on iron metabolism in erythroblasts. in Experimental hematology 2017
Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death.
High serum ferritin (SF) and the overall survival of allogeneic hematopoietic SF was only significantly associated with prolonged RBC transfusion dependence post-transplantation.
the role of FTH1 in the FIH control of HIF-1 activity, is reported.
CD16 expression and morphological maturity of neutrophils are associated with higher iron ferritin levels in major beta-thalassemia.
Study demonstrate that the amounts of ferritin heavy subunit are inversely correlated, in K562 cells, to H19/miR-675 levels, and that this phenomenon may be largely attributed to the increase in ROS production induced by the FHC silencing.
Findings indicate that induction of EMT, increased migration and survival depend, in MCF-7 and H460 cells, on the release of FHC control on two pathways, namely the iron/ROS metabolism and CXCR4/CXCL12 axis.
ferritin heavy chain has a role in ovarian cancer stem cell expansion and epithelial to mesenchymal transition
Report in vivo magnetic resonance imaging of xenografted neuroblastoma tumors using FTH1 reporter gene expression controlled by a tet-on switch.
The H-ferritin could bind up to 24 NCOA4(383-522) fragments forming highly stable and insoluble complexes. The binding was partially inhibited only by Fe(II) among the various divalent metal ions analyzed. The iron-dependent, highly-specific formation of the remarkably stable H-ferritin-NCOA4 complex shown in this work may be important for the characterization of the mechanism of ferritinophagy.
Recombinant human H-chain ferritin nanocages were characterized by transmission electron microscopy and dynamic light scattering. These results indicate that H-chain ferritin is able to self-assemble into nanocages with a narrow size distribution.
Among myelodysplastic syndromes patients only, CD163 + macrophage density and HO1 and H-ferritin expression by CD163 + macrophages increased in tandem with marrow iron. High HO1 was significantly associated with shorter overall survival.
Low levels of FTH-positive tumor cells and microglia/macrophages were associated with poor survival in anaplastic astrocytomas, while high amounts of FTL-positive microglia/macrophages had a negative prognostic value
fumarate increases ferritin gene transcription by activating the NRF2 (nuclear factor [erythroid-derived 2]-like 2) transcription factor.
there is no significant relationship between serum ferritin concentrations and depressive symptoms among Chinese adults.
Data suggest that, in homopolymeric H-subunit ferritin (HuHF), iron oxidation proceeds with a 2:1 Fe(II):O(2) stoichiometry at iron level of 2 Fe(II) atoms/H-subunit with generation of H2O2; L-subunit-rich heteropolymeric ferritin also facilitates iron oxidation at the ferroxidase center and additionally promotes oxidation at the mineral surface once iron-binding capacity has been exceeded.
Elevated serum ferritin levels are associated with hematologic malignancies.
Ferritin light chain and ferritin heavy chain are required for the neural differentiation of bone marrow-derived mesenchymal stem cells under extremely low-frequency electromagnetic field.
Human FTH1 is a general pro-survival sequence.
H-ferritin tissue expression and the number of CD68+/H-ferritin+ cells were increased in the lymph nodes of adult-onset Still's disease patients, and these results correlated significantly with disease severity
Stopped-flow kinetics assays revealed that human H ferritin has different levels of activity compared with its R. catesbeiana counterpart
Ferritin H subunit gene is specifically expressed in melanophore precursor-derived white pigment cells
ferritin heavy chain up-regulation may be mediated by activation of NF-kappaB and that in turn this may be related to the resistance of bovine papillomavirus type-2 (BPV-2) infected urothelial cells to apoptosis.
FtMt overexpressing mice have no significant defects and the overexpression of FtMt does not affect the regulation of iron metabolism significantly in transgenic mice.
Ferritin is considered the major iron storage protein which maintains a large iron core in its cavity and has ferroxidase activity. (Review)
the absence of Mitochondrial ferritin, which is highly expressed in the heart, increases the sensitivity of mitochondria to cardiac injury via oxidative stress.
As previously reported, homozygous loss of the Fth allele on a wild-type Ftl background was embryonic lethal. expression of the H subunit can rescue the loss of the L subunit and that H ferritin homopolymers have the capacity to sequester iron in vivo
provide a new mechanism for selective autophagy of ferritin and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo
Our data show that ferritin H is required for B and T cell survival by actively reducing the labile iron pool.
Ferritin H deficiency in most cells of the forebrain including cells of the choroid plexus caused accumulation of cerebrospinal fluid in the lateral ventricles and the subarachnoid space
Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2.
3-Hydroxybutyrate dehydrogenase-2 and ferritin-H synergistically regulate intracellular iron.
Fth plays a critical protective role during acute kidney injury.
FtH provides metabolic adaptation to tissue Fe overload, conferring tolerance to malaria
The delivery of iron to oligodendrocytes via H-ferritin is a biologically relevant delivery system, given that ferritin--not transferrin--receptors can be demonstrated on oligodendrocytes in vivo.
HFt taken up by TIM-2 positive cells transited through the endosome and eventually entered a lysosomal compartment, distinguishing the HFt pathway from that of transferrin
Mitochondrial ferritin is found in all regions of the brain in C57/BL6 mice; the role of mitochondrial ferritin can be expected to contribute to our knowledge of mitochondrial dysfunction and neurodegenerative disease.
Loss of one allele of H ferritin appears to increase light-induced degeneration.
Hx plays an important role in controlling iron distribution within brain, thus suggesting its involvement in iron-related neurodegenerative diseases.
FTH expression is mediated by Nrf2 in response to xenobiotics and cancer chemopreventive dithiolethiones
Ferritin heavy chain 1 necessary for tumor necrosis factor alpha-induced apoptosis in L929 cells.
excessive free iron and the resultant enhanced oxidative stress caused by downregulation of FHC lead to cardiomyocyte death
The X-ray crystal structure of the apoferritin-SDS complex was determined at a resolution of 1.9 A and revealed that the SDS binds in an internal cavity that has previously been shown to recognize various general anesthetics. [apoferritin]
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
, cell proliferation-inducing gene 15 protein
, ferritin H subunit
, ferritin heavy chain
, placenta immunoregulatory factor
, proliferation-inducing protein 15
, ferritin H chain
, ferritin H subunit A
, ferritin heavy chain 2
, ferritin heavy chain A
, ferritin H subunit B
, ferritin heavy chain 1
, ferritin heavy chain B
, ferritin, heavy polypeptide 1 b
, ferritin heavy polypeptide 1
, ferritin heavy-chain
, Ferritin subunit H
, ferritin, heavy polypeptide 1
, Ferritin H subunit
, ferritin heavy chain 1 a