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Mouse (Murine) FTH1 Protein expressed in Escherichia coli (E. coli) - ABIN1079501
Inokura, Fujiwara, Saito, Iino, Hatta, Okitsu, Fukuhara, Onishi, Ishizawa, Shimoda, Harigae: Impact of TET2 deficiency on iron metabolism in erythroblasts. in Experimental hematology 2017
ferritin heavy chain has a role in ovarian cancer stem cell expansion and epithelial to mesenchymal transition
Report in vivo magnetic resonance imaging of xenografted neuroblastoma (show ARHGEF16 Proteins) tumors using FTH1 reporter gene expression controlled by a tet-on switch.
The H-ferritin could bind up to 24 NCOA4 (show NCOA4 Proteins)(383-522) fragments forming highly stable and insoluble complexes. The binding was partially inhibited only by Fe(II) among the various divalent metal ions analyzed. The iron-dependent, highly-specific formation of the remarkably stable H-ferritin-NCOA4 (show NCOA4 Proteins) complex shown in this work may be important for the characterization of the mechanism of ferritinophagy.
Recombinant human H-chain ferritin (show FTL Proteins) nanocages were characterized by transmission electron microscopy and dynamic light scattering. These results indicate that H-chain ferritin (show FTL Proteins) is able to self-assemble into nanocages with a narrow size distribution.
Among myelodysplastic syndromes patients only, CD163 (show CD163 Proteins) + macrophage density and HO1 (show HMOX1 Proteins) and H-ferritin expression by CD163 (show CD163 Proteins) + macrophages increased in tandem with marrow iron. High HO1 (show HMOX1 Proteins) was significantly associated with shorter overall survival.
Low levels of FTH-positive tumor cells and microglia/macrophages were associated with poor survival in anaplastic astrocytomas, while high amounts of FTL (show FTL Proteins)-positive microglia/macrophages had a negative prognostic value
fumarate increases ferritin (show FTL Proteins) gene transcription by activating the NRF2 (show GABPA Proteins) (nuclear factor [erythroid-derived 2]-like 2) transcription factor.
there is no significant relationship between serum ferritin (show FTL Proteins) concentrations and depressive symptoms among Chinese adults.
Data suggest that, in homopolymeric H-subunit ferritin (show FTL Proteins) (HuHF), iron oxidation proceeds with a 2:1 Fe(II):O(2) stoichiometry at iron level of 2 Fe(II) atoms/H-subunit with generation of H2O2; L-subunit-rich heteropolymeric ferritin (show FTL Proteins) also facilitates iron oxidation at the ferroxidase (show CP Proteins) center and additionally promotes oxidation at the mineral surface once iron-binding capacity has been exceeded.
Elevated serum ferritin (show FTL Proteins) levels are associated with hematologic malignancies.
Ferritin H subunit gene is specifically expressed in melanophore precursor-derived white pigment cells
ferritin heavy chain up-regulation may be mediated by activation of NF-kappaB (show NFKB1 Proteins) and that in turn this may be related to the resistance of bovine papillomavirus type-2 (BPV-2) infected urothelial cells to apoptosis.
Ferritin (show FTL Proteins) is considered the major iron storage protein which maintains a large iron core in its cavity and has ferroxidase (show CP Proteins) activity. (Review)
the absence of Mitochondrial ferritin (show FTMT Proteins), which is highly expressed in the heart, increases the sensitivity of mitochondria to cardiac injury via oxidative stress.
As previously reported, homozygous loss of the Fth allele on a wild-type Ftl (show FTL Proteins) background was embryonic lethal. expression of the H subunit can rescue the loss of the L subunit and that H ferritin homopolymers have the capacity to sequester iron in vivo
provide a new mechanism for selective autophagy of ferritin (show FTL Proteins) and reveal a previously unappreciated role for autophagy and NCOA4 (show NCOA4 Proteins) in the control of iron homeostasis in vivo
Our data show that ferritin H (show FTMT Proteins) is required for B and T cell survival by actively reducing the labile iron pool.
Ferritin H (show FTMT Proteins) deficiency in most cells of the forebrain including cells of the choroid plexus caused accumulation of cerebrospinal fluid in the lateral ventricles and the subarachnoid space
Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2.
3-Hydroxybutyrate dehydrogenase (show BDH1 Proteins)-2 and ferritin-H (show FTMT Proteins) synergistically regulate intracellular iron.
Fth plays a critical protective role during acute kidney injury.
FtH provides metabolic adaptation to tissue Fe overload, conferring tolerance to malaria
Fe mediated decrease of lateral root length and density is enhanced in fer1-3-4 triple mutant plants.
phosphate starvation response of AtFer1 is not linked to the iron status of plants and is specifically initiated by phosphate deficiency
Data indicate that steady-state mRNA abundance for three representative Fe homeostasis genes, IRT1 (show PARP3 Proteins), bHLH39, and FER1, oscillated in light/dark (LD) cycles or warm/cold environmental cycles.
Data show that a leaf glutathione concentration threshold between 10 and 50 nmol GSHg(-1) FW is required for full induction of AtFer1 gene expression in response to iron.
new regulatory pathway involved in plant response to oxidative stress was revealed using the iron-induced Arabidopsis ferritin (show FTL Proteins) AtFER1 as a model
Ferritin (show FTL Proteins) accumulation during infection of Arabidopsis by E. chrysanthemi is a basal defense mechanism which is mainly activated by bacterial siderophores.
The X-ray crystal structure of the apoferritin-SDS (show SDS Proteins) complex was determined at a resolution of 1.9 A and revealed that the SDS (show SDS Proteins) binds in an internal cavity that has previously been shown to recognize various general anesthetics. [apoferritin]
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
, cell proliferation-inducing gene 15 protein
, ferritin H subunit
, ferritin heavy chain
, placenta immunoregulatory factor
, proliferation-inducing protein 15
, ferritin H chain
, ferritin H subunit A
, ferritin heavy chain 2
, ferritin heavy chain A
, ferritin H subunit B
, ferritin heavy chain 1
, ferritin heavy chain B
, ferritin, heavy polypeptide 1 b
, ferritin heavy polypeptide 1
, ferritin heavy-chain
, Ferritin subunit H
, ferritin, heavy polypeptide 1
, Ferritin H subunit