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important roles for c-Src tyrosine kinase (show CSK Proteins) in phosphorylation and activation of SLC11A1 in macrophages
3'UTR-NRAMP1 gene and VDR-Taq1 gene Polymorphisms are statistically associated with the susceptibility of TB in Andhra Pradesh Population in India.
Nramp1 is expressed in microglia and neurons in the striatum of human brain and response for degrading alpha-synuclein oligomers in microglia.
This study identified several important polymorphisms in the ITPKC (show ITPKC Proteins) and SLC11A1 genes in Koreans.
Studied the role of natural resistance associated macrophage protein 1 (NRAMP1) polymorphisms (D543N, INT4 (show WNT3 Proteins)) in pulmonary tuberculosis risk. For D543NA/G polymorphism, no associations were found in all genetic models. For INT4C/G polymorphism, significant increased PTB (show PTBP1 Proteins) risk was observed in recessive model.
This study shows that genetic variations in the candidate gene SLC11A1 do not affect susceptibility to cutaneous leishmaniasis in the sample population from Pakistan.
in patients with non-muscle-invasive bladder cancer, the NRAMP1 D534N polymorphism could increase the risk of recurrence
Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta/E2F1 (show E2F1 Proteins) axis-upregulated LSH (show HELLS Proteins) promoted gliomas.
Our data suggest that the D543N variant of SLC11A1 gene has a protective effect in the development of rheumatoid arthritis in a Mexican Mestizo population
SLC11A1 expression is significantly upregulated in human masticatory mucosa during wound healing
Study shows that, before and after weaning, Nramp1 was highly expressed in digestive (stomach) and intestinal (duodenum, jejunum, and ileum) tissues, further indicating a genetic role in both immune regulation to compensate for weaning stress and enhanced development of intestinal immunity.
The frequency of allele B and A was 0.93 and 0.90 on a total of 180 and 205 pigs for the polymorphism in intron 1 and intron 2 of the Nramp1 gene respectively in a mixed population of hybrid and purebred pigs.
Genomic organization and polymorphisms detected by denaturing HPLC of porcine NRAMP1 gene are reported.
a significant correlation between different genotypes of Nramp1 gene and immune function and production performance
SLC11A1 is a useful candidate gene related to tuberculosis in Chinese Holstein cattle.
Polymorphisms in SLC11A1 and CXCR1 (show CXCR1 Proteins) are significantly associated with bovine mastitis
Analysis of allelic variants in the first and second microsatellite at the 3;UTR region of the SLC11A1 gene in cattle breeds present in Argentina.
Preferential expression of SLC11A1 transcripts in gammadelta T cells is detected in bovine, human, and mouse gammadelta T cells.
NRAMP1 consists of multiple targeting motifs for trafficking into lysosomes.
DNA sequence analysis of NRAMP1 gene polymorphisms from 5 different cattle breeds
Identification of a novel polymorphism within the bovine NRAMP 1 gene intron X.
Study compared the frequency of Nramp1 3'UTR polymorphisms between Zebu and European bovine breeds.
The expression of iNOS (show NOS2 Proteins) and NRAMP1 in the lymph nodes, lungs, and tuberculous granulomas in 8 bovine tuberculosis cases is reported.
These results indicate that these polymorphisms at the NRAMP1 3'UTR do not affect resistance against B. abortus in cattle.
Our data demonstrated the fine-tuning roles of Slc11a1 alleles modulating macrophage activation, and consequent pristane-induced arthritis susceptibility.
Here, the authors show that genetic inactivation of a single DDM1/Lsh (show HELLS Proteins) family nucleosome remodeler biases methylation toward inter-nucleosomal linker DNA in Arabidopsis thaliana and mouse. The results indicate that in the absence of remodeling, nucleosomes are strong barriers to DNA methyltransferases.
discrete, anatomically localized host resistance is conferred by Nramp1 expression; restriction of systemic bacterial growth in the spleen is enhanced by Nramp1 expression
Data shows that Lsh (show HELLS Proteins) plays an essential Dnmt3b (show DNMT3B Proteins)-independent role to ensure that the host genome integrity is protected from potentially deleterious LTR retroelements.
Gene expression profiles of the two arthritis quantitative trait loci (on chromosomes 5 and 8) correlate with Slc11a1 alleles, resulting in enhanced AIRmax(SS) mice susceptibility to Pristane-induced arthritis.
In the absence of LSH, the histone variant H2AX is not efficiently phosphorylated in response to DNA damage.
These observations indicate a bifunctional protective role of secretory Prx (show PRX Proteins); first it reduces redox activation of macrophages, and secondly it allows iron access to Leishmania by down regulating NRAMP1 expression.
Stimulation of Lcn2 (show LCN2 Proteins) expression is a novel mechanism by which Nramp1 confers resistance against infection with Salmonella typhimurium.
High inflammatory AIRmax mice homozygous for Slc11a1 R and S alleles were produced. The Slc11a1 gene modulated the early inflammatory events of ear tissue regeneration.
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
, natural resistance associated macrophage protein 1
, natural resistance-associated macrophage protein 1
, natural resistance-associated macrophage protein 1-like
, NRAMP 1
, solute carrier family 11 (sodium/phosphate symporters), member 1
, solute carrier family 11 member 1
, host resistance locus Bcg/Ity/Lsh
, natural resistant-associated macrophage protein 1
, natural resistance associated macrophage protein