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important roles for c-Src tyrosine kinase in phosphorylation and activation of SLC11A1 in macrophages
3'UTR-NRAMP1 gene and VDR-Taq1 gene Polymorphisms are statistically associated with the susceptibility of TB in Andhra Pradesh Population in India.
Nramp1 is expressed in microglia and neurons in the striatum of human brain and response for degrading alpha-synuclein oligomers in microglia.
This study identified several important polymorphisms in the ITPKC and SLC11A1 genes in Koreans.
Studied the role of natural resistance associated macrophage protein 1 (NRAMP1) polymorphisms (D543N, INT4) in pulmonary tuberculosis risk. For D543NA/G polymorphism, no associations were found in all genetic models. For INT4C/G polymorphism, significant increased PTB risk was observed in recessive model.
This study shows that genetic variations in the candidate gene SLC11A1 do not affect susceptibility to cutaneous leishmaniasis in the sample population from Pakistan.
in patients with non-muscle-invasive bladder cancer, the NRAMP1 D534N polymorphism could increase the risk of recurrence
Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta/E2F1 axis-upregulated LSH promoted gliomas.
Our data suggest that the D543N variant of SLC11A1 gene has a protective effect in the development of rheumatoid arthritis in a Mexican Mestizo population
The results indicated that genetic variations of D543N (rs17235409) might be associated with susceptibility to cutaneous leishmaniasis infection.
SLC11A1 expression is significantly upregulated in human masticatory mucosa during wound healing
We found a statistical association between polymorphisms in 3'UTR region and exon 8 and CL [chi(2) = 13.26; p < 0.05; OR = 17.00; IC of 95% (2.24-128.99)]. Some patients who needed more than 40 doses of Glucantime(R) to heal injuries presented mutations in exons 3, 8, and 15. Multiple or ear lesions were not associated with NRAMP1 polymorphism.
distriburtion of polymorphism allelle frequency at the INT4 region associated with oropharyngeal tularemia
we conclude that presence of G allele of NRAMP1 in both rs2276631 and rs17235409 location may be a protective factor against chronic periodontitis
our meta-analysis demonstrated that no significant association was identified between genetic susceptibility to UC/CD and polymorphisms of NRAMP1 gene, including (GT)n allele 2, 274 C/T, 1729+55del4 (TGTG) +/del in overall population.
The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH
The 274C/T polymorphism in exon 3 and the 469+14G/C polymorphism in intron 4 of the Slc11a1/Nramp1 gene were associated with susceptibility to leprosy, while the allele 2 and 3 of the (GT)n polymorphism in the promoter region were associated with susceptibility and protection to leprosy, respectively.
investigation of NRAMP1, MBL, MBL, VDR gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis in a Chinese population; study suggests that genotypes of many polymorphic genes are associated with TB
No significant difference was found for NRAMP1 and hGPX1 gene polymorphisms associated with recurrence time.
NRAMP1 3'UTR variants were associated with susceptibility to M. tuberculosis infection.
Study shows that, before and after weaning, Nramp1 was highly expressed in digestive (stomach) and intestinal (duodenum, jejunum, and ileum) tissues, further indicating a genetic role in both immune regulation to compensate for weaning stress and enhanced development of intestinal immunity.
The frequency of allele B and A was 0.93 and 0.90 on a total of 180 and 205 pigs for the polymorphism in intron 1 and intron 2 of the Nramp1 gene respectively in a mixed population of hybrid and purebred pigs.
Genomic organization and polymorphisms detected by denaturing HPLC of porcine NRAMP1 gene are reported.
a significant correlation between different genotypes of Nramp1 gene and immune function and production performance
SLC11A1 is a useful candidate gene related to tuberculosis in Chinese Holstein cattle.
Polymorphisms in SLC11A1 and CXCR1 are significantly associated with bovine mastitis
Analysis of allelic variants in the first and second microsatellite at the 3;UTR region of the SLC11A1 gene in cattle breeds present in Argentina.
Preferential expression of SLC11A1 transcripts in gammadelta T cells is detected in bovine, human, and mouse gammadelta T cells.
NRAMP1 consists of multiple targeting motifs for trafficking into lysosomes.
DNA sequence analysis of NRAMP1 gene polymorphisms from 5 different cattle breeds
Identification of a novel polymorphism within the bovine NRAMP 1 gene intron X.
Study compared the frequency of Nramp1 3'UTR polymorphisms between Zebu and European bovine breeds.
the present study demonstrated that the presence of (GT)(13) allele even in homozygous condition could not provide enough resistance to brucellosis in a naturally infected herd
The expression of iNOS and NRAMP1 in the lymph nodes, lungs, and tuberculous granulomas in 8 bovine tuberculosis cases is reported.
These results indicate that these polymorphisms at the NRAMP1 3'UTR do not affect resistance against B. abortus in cattle.
Genotype of the SLC11A1 gene is associated with resistance to brucellosis.
No associations were observed between the detected polymorphisms and somatic cell scores and milk yield in the Chinese Holstein population.
Data suggested that Nramp1 may be a candidate gene responsible for mastitis in Holstein cattle.
A tendency toward statistical significance for the effect of polymorphisms in the odds of infection in cattle was only found for alleles SLC11A1.
Our data demonstrated the fine-tuning roles of Slc11a1 alleles modulating macrophage activation, and consequent pristane-induced arthritis susceptibility.
Here, the authors show that genetic inactivation of a single DDM1/Lsh family nucleosome remodeler biases methylation toward inter-nucleosomal linker DNA in Arabidopsis thaliana and mouse. The results indicate that in the absence of remodeling, nucleosomes are strong barriers to DNA methyltransferases.
discrete, anatomically localized host resistance is conferred by Nramp1 expression; restriction of systemic bacterial growth in the spleen is enhanced by Nramp1 expression
Data shows that Lsh plays an essential Dnmt3b-independent role to ensure that the host genome integrity is protected from potentially deleterious LTR retroelements.
Gene expression profiles of the two arthritis quantitative trait loci (on chromosomes 5 and 8) correlate with Slc11a1 alleles, resulting in enhanced AIRmax(SS) mice susceptibility to Pristane-induced arthritis.
In the absence of LSH, the histone variant H2AX is not efficiently phosphorylated in response to DNA damage.
These observations indicate a bifunctional protective role of secretory Prx; first it reduces redox activation of macrophages, and secondly it allows iron access to Leishmania by down regulating NRAMP1 expression.
Stimulation of Lcn2 expression is a novel mechanism by which Nramp1 confers resistance against infection with Salmonella typhimurium.
High inflammatory AIRmax mice homozygous for Slc11a1 R and S alleles were produced. The Slc11a1 gene modulated the early inflammatory events of ear tissue regeneration.
anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin expression, is influenced by Nramp1 and may involve lipocalin-2.
The Yersinia pseudotuberculosis mntH mutant was defective in survival and growth in macrophages expressing functional Nramp1, but in macrophages deficient in Nramp the bacteria were able to survive and replicate.
conclude that rs3731685 (INT4) in the SLC11A1 gene may be associated with T1D susceptibility in the European ancestry population studied
Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences.
Findings indicate that DeltaNp63alpha is an oncogene that cooperates with Ras to promote tumor-initiating stem-like proliferation and suggest that Lsh-mediated chromatin-remodeling events are critical to this process.
Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling.
Results indicate that Lsh is involved in the control of stem cell genes and suggest that Lsh is an important epigenetic modulator during early stem cell differentiation.
Affects macrophage-mediated anti-cryptococcal defense
Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake
involvement of Nramp1 in controlling S. enteritidis clearance during the late phase of infection
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
, natural resistance associated macrophage protein 1
, natural resistance-associated macrophage protein 1
, natural resistance-associated macrophage protein 1-like
, NRAMP 1
, solute carrier family 11 (sodium/phosphate symporters), member 1
, solute carrier family 11 member 1
, host resistance locus Bcg/Ity/Lsh
, natural resistant-associated macrophage protein 1
, natural resistance associated macrophage protein