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Lrp6 asymmetry is controlled by Wnt (show WNT2 Proteins)/PCP (show PRCP Proteins) signaling, indicating that this pathway regulates not only planar- but also apicobasal cell polarity.
PTK7 (show PTK7 Proteins) and LRP6 proteins physically interact, suggesting that PTK7 (show PTK7 Proteins) stabilization of LRP6 protein reciprocally regulates both canonical and noncanonical Wnt (show WNT2 Proteins) activities in the embryo.
Results suggest that Rap2 (show RAP2A Proteins) acts via TNIK (show TNIK Proteins) to regulate the stability of LRP6 receptor for Wnt (show WNT2 Proteins) signaling.
The extracellular domains of Lrp5 (show LRP5 Proteins)/6 behave as physiologically relevant inhibitors of noncanonical Wnt (show WNT2 Proteins) signaling during Xenopus and mouse development in vivo.
Lrp6 plays a critical role in the switch from Wnt (show WNT2 Proteins)/PCP (show PRCP Proteins) to Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Kremen2 (show KREMEN2 Proteins) knockdown specifically reduces LRP6 protein levels in neural crest explants.
Waif1a binds to the Wnt (show WNT2 Proteins) coreceptor LRP6 (show LRP5 Proteins) and inhibits Wnt (show WNT2 Proteins)-induced LRP6 (show LRP5 Proteins) internalization into endocytic vesicles, a process that is required for pathway activation.
Results identify GRK5 (show GRK5 Proteins)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP5 Proteins) during Wnt (show WNT2 Proteins) signaling.
knockdown of LRP6 inhibited the cell viability by activation of Drp1 (show CRMP1 Proteins) in glucose deprived-cardiomyocytes.
Three rare missense mutations (c.1514A>G, p.Y505C); c.2984A>G, p.D995G; and c.4280C>A, p.P1427Q) of the LRP6 gene were identified in Chinese NTD patients. The Y505C mutation is a loss-of-function mutation on both WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and PCP (show PRCP Proteins) signaling. The D995G mutation partially lost inhibition on PCP (show PRCP Proteins) signaling without affecting WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling. The P1427Q mutation dramatically increased WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signa...
LRP6 endocytosis proceeds by two routes, depending on the presence of LDL, and that LRP6 controls the intracellular destination of NPC1L1 (show NPC1L1 Proteins) in hepatocytes.
High Expressions of LRP6 is associated with cancer.
LRP6 expression was found to be upregulated in oral squamous cell carcinoma tissues, and correlated with a cluster of clinicopathologic parameters, including smoking, drinking, tumor differentiation status, lymph node metastasis and survival time.
CCN2 (show CTGF Proteins) plays a promoting role in hepatocellular carcinoma (HCC (show FAM126A Proteins))progression through activating LRP6 in a HSPGs-dependent manner. Heparin in combination with chemotherapy has a synergic effect and could be a treatment choice for HCCs (show HCCS Proteins) with a high CCN2 (show CTGF Proteins) expression.
Increased LRP6 gene expression is associated with colorectal cancer.
Therefore, our study demonstrates that miR (show MLXIP Proteins)-183 is a tumor suppressor microRNA that plays a major role in OS.
data suggest that LRP6 promotes negative breast cancer cell migration and invasion by regulating the expression and function of S100A4 (show S100A4 Proteins) via the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway
sustained activation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling due to abrogation of Merlin (show NF2 Proteins)-mediated inhibition of LRP6 phosphorylation may be a cause of Neurofibromatosis type II disease.
In this study, we found that the wnt (show WNT2 Proteins) co-receptor Lrp6 was a potent positive regulator of beta-catenin (show CTNNB1 Proteins) signaling in TDI-induced asthma models, both in vivo and in vitro. Additionally, for the first time, we demonstrated that RAGE (show AGER Proteins) could mediate phosphorylation of Lrp6, suggesting a functional cross talk between RAGE (show AGER Proteins) and the canonical wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway involved in mediating beta-catenin (show CTNNB1 Proteins) activation.
LRP6 acts as a scaffold protein (show HOMER1 Proteins) in cardiac gap junction assembly and intracellular protein (show CKAP2 Proteins) trafficking.
Data show that reduction of alpha chain (show FCGRT Proteins) of nascent polypeptide associated complex (show NACa1 Proteins) (alphaNAC) levels decreased basal expression of Low density lipoprotein receptor-Related Protein 6 (Lrp6) by 30%.
GPR37 is required for Wnt/beta-catenin signaling and protects LRP6 from ER-associated degradation via CHIP (carboxyl terminus of Hsc70-interacting protein) and the ATPase VCP
Lrp6 is the key mediator of Wnt3a (show WNT3A Proteins) signaling in osteoblasts and Lrp5 (show LRP5 Proteins) played a less significant role in mediating Wnt3a (show WNT3A Proteins) signaling.
VAP1 (show AOC3 Proteins) cleaved recombinant mouse LRP6, producing a 140-kDa fragment. An antibody against a peptide including the LRP6-cleavage site inhibited VAP1 (show AOC3 Proteins)-induced VE-cadherin (show CDH5 Proteins) relocation and disruption of cell-cell adhesions and blocked haemorrhage in mice in vivo.
we identified Lrp6, the gene encoding the coreceptor to Frizzled in the Wnt (show WNT2 Proteins) pathway, as a potential negative regulator of precursor proliferation. Overexpression and siRNA silencing confirmed the regulatory role of Lrp6
These results revealed a new role of the canonical Lrp5 (show LRP5 Proteins)/6-beta-catenin (show CTNNB1 Proteins) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
Data (including data from studies in knockout/transgenic mice) suggest Lrp6 is required for suppression of Sost (sclerostin (show SOST Proteins)) expression by parathyroid hormone (show PTH Proteins) (here, human PTH (show PTH Proteins) peptide 1-34); LRP6 regulates osteocytes expression of histone deacetylases.
Lrp5 (show LRP5 Proteins) binds to Frizzled, preventing Frz-regulated non-canonical Wnt (show WNT2 Proteins) pathway activation and further non-canonical pathway-mediated tumour metastasis.
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
low density lipoprotein receptor-related protein 6
, lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6-like
, low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6
, low density lipoprotein-related protein 6