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a SDF-1 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins)-RhoA (show RHOA Proteins) and RhoC-ROS (show ROS1 Proteins)-cytoskeleton pathway that regulates Jurkat cell migration in response to SDF-1 (show CXCL12 Proteins).
Studied the involvement in epithelial ovarian cancer (EOC) of lncRNA ABHD11 (show ABHD11 Proteins)-AS1 (show PTGDR Proteins) in and the regulation of EOC by RhoC.
Out of multiple members of this family, RhoA (show RHOA Proteins) and RhoC are important factors. RhoA (show RHOA Proteins) is supposed to increase tumor proliferation when overexpressed while RhoC is responsible for tumor initiation.
Spatiotemporal analysis of RhoA (show RHOA Proteins)/RhoB/RhoC activation in primary human endothelial cells has been uncovered.
YMO1 (show EPB41L5 Proteins) suppresses tumor invasion and metastasis by inhibiting RhoC activity.
this studies show the ability of miR (show MLXIP Proteins)-10b to activate the expression of c-Jun (show JUN Proteins) through RhoC and NF1 (show NF1 Proteins), which represents a novel pathway for promoting migration and invasion of human cancer cells
swapping residue 188 identity effectively flips the membrane binding profile of wild-type RhoA (show RHOA Proteins) and RhoC through positive arginine contribution rather than negative phosphoserine regulation
HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells.
E2F transcription factor 1 (E2F1 (show E2F1 Proteins)) downregulated micrRNA miR (show MLXIP Proteins)-519d directly and miR (show MLXIP Proteins)-519d downregulated Ras homolog gene family member C (RhoC) directly.
These results reveal a previously unidentified pathway downstream of RHO that regulates the polarity of migrating cells through Golgi reorientation in a FAM65A-, CCM3 (show PDCD10 Proteins)- and MST3 (show STK24 Proteins)- and MST4 (show MST4 Proteins)-dependent manner.
what was seen for RhoC, mDia1 silencing through RNAi inhibited phagosome formation. Additionally, the coexpression of mDia1 with constitutively active mutant RhoC-G14V or expression of active mutant mDia1-DeltaN3 drastically inhibited the uptake of IgG-Es. These data suggest that RhoC modulates phagosome formation be modifying actin cytoskeletal remodeling via mDia1
RhoC co-localizes with Fam65b (show FAM65B Proteins) in stereocilia and regulates Fam65b (show FAM65B Proteins) oligomerization what is critical for hair cell function.
Inhibition of ovarian epithelial carcinoma tumorigenesis and progression by miR106b proceeds through the RhoC pathway.
RHOC and RAB38 (show RAB38 Proteins) are dispensable for osteoclast function.
A p27(kip1 (show CDKN1B Proteins))-binding protein, p27RF-Rho (show LAMTOR1 Proteins), promotes cancer metastasis via activation of RhoA (show RHOA Proteins) and RhoC.
We found that both RhoA and RhoC, but not RhoB, were required for initiation of centrosome duplication, and overactivation of RhoA, as well as RhoC, but not RhoB, promoted centrosome duplication and centrosome amplification.
RhoC has a role in metastasis of lung cancer in mice
loss of RhoC does not affect tumor development but decreases tumor cell motility and metastatic cell survival leading to a drastic inhibition of metastasis
RhoC promotes melanoma progression via separate mechanisms that regulate the PI3K/Akt (show AKT1 Proteins) pathway and the ROCK signaling pathway.
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
ras homolog gene family, member C
, rho-related GTP-binding protein RhoC
, RAS-related homolog 9
, oncogene RHO H9
, rho cDNA clone 9
, rhoC GTPase
, small GTP binding protein RhoC
, aplysia ras-related homolog 9 (RhoC)
, ras homolog 9 (RhoC)
, silica-induced gene 61 protein
, GTP-binding protein
, GTPase cRhoC