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We demonstrated that the AR-miR-1 (show FSD1 Proteins) axis negatively regulates the novel oncogenic factor, TCF7. Dysregulation of TCF7 promoted a survival advantage and resistance to androgen deprivation, suggesting its therapeutic potential for castration-resistant prostate cancer.
High expression of TCF7 is associated with osteosarcoma.
Findings indicate that breast cancer cells with a hyperactive AF1q (show MLLT11 Proteins)/TCF7/CD44 (show CD44 Proteins) regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
TCF7 plays critical roles in lung diseases [review]
Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective respo (show GIP Proteins)nsiveness to GIP and enhances the magnitude of apoptotic injury.
Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin (show CTNNB1 Proteins) signaling due to the dissociation of beta-catenin (show CTNNB1 Proteins)/TCF-1 (show HNF1A Proteins) complex and the process was orchestrated by STAT-3 (show STAT3 Proteins).
we show that TCF7 is a direct target of miR (show MLXIP Proteins)-34a in prostate cancer that has metastasized to the bone
induction of expression activates the Wnt (show WNT2 Proteins) signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation
RUNX2 (show RUNX2 Proteins) signaling pathways with their partners TCF7 and FGFR1 (show FGFR1 Proteins)/2 may not be involved in CCD (show RUNX2 Proteins) pathogenesis
Results suggest ivermectin as therapeutic WNT protein-TCF (show HNF4A Proteins) transcription factor pathway response blocker to treat WNT (show WNT2 Proteins)-TCF (show HNF4A Proteins)-dependent diseases including multiple cancers.
This is attributed in part to ineffective repression of Tcf1 (show HNF1A Proteins) expression in knockout T cells, as DNMT3a (show DNMT3A Proteins) localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8 (show CD8A Proteins)(+) T cells. These data identify DNMT3a (show DNMT3A Proteins) as a crucial regulator of CD8 (show CD8A Proteins)(+) early effector cell differentiation and effector versus memory fate decisions.
The balance between CD4 (show CD4 Proteins)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 (show BCL6 Proteins) and Tcf7 (encoding TCF-1 (show HNF1A Proteins)) and by the expression of the inhibitory receptors PD-1 (show PDCD1 Proteins) and LAG3 (show LAG3 Proteins).
data reveal that T cell factor 1 (Tcf1) long and short isoforms have distinct, yet complementary, functions and may represent an evolutionarily conserved means to ensure proper programming of CD8 (show CD8A Proteins)(+) and CD4 (show CD4 Proteins)(+) T cell responses to viral infection
Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP (show GIP Proteins) and enhances the magnitude of apoptotic injury.
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
The data suggest that miR (show MLXIP Proteins)-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 (show HNF1A Proteins) expression in osteoblastic cells.
this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage
Our results support a critical role for miR (show MLXIP Proteins)-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis.
TCF-1 (show HNF1A Proteins) was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection. TCF-1 (show HNF1A Proteins) promoted Bcl-6 (show BCL6 Proteins) expression but repressed Blimp1 (show PRDM1 Proteins) expression.
Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 (show CCR7 Proteins) as Foxo1 (show FOXO1 Proteins)-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking.
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
T-cell-specific transcription factor 1
, transcription factor 7
, transcription factor 7, T-cell specific
, T cell factor-1
, T-cell factor 1