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anti-Human WNT5A Antibodies:
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Cow (Bovine) Polyclonal WNT5A Primary Antibody for IHC, IHC (p) - ABIN4366188
Rao, Liu, Zhou, Ma, Lu, Zhou: Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas. in Tumori 2010
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Human Monoclonal WNT5A Primary Antibody for IF, IHC - ABIN967259
Martino, Olsen, Fulcher, Wolfgang, ONeal, Ribeiro: Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1. in The Journal of biological chemistry 2009
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Human Monoclonal WNT5A Primary Antibody for ICC, IHC - ABIN969460
Dai, Hall, Escara-Wilke, Mizokami, Keller, Keller: Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms. in Cancer research 2008
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Human Monoclonal WNT5A Primary Antibody for IHC, ELISA - ABIN969461
Ford, Ekström, Andersson: Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells. in Proceedings of the National Academy of Sciences of the United States of America 2009
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Dog (Canine) Polyclonal WNT5A Primary Antibody for IF (p), IHC (p) - ABIN675758
Król, Mucha, Majchrzak, Homa, Bulkowska, Majewska, Gajewska, Pietrzak, Perszko, Romanowska, Paw?owski, Manuali, Hellmen, Motyl: Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors. in PLoS ONE 2014
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Human Monoclonal WNT5A Primary Antibody for IHC (p), ELISA - ABIN521385
Thiele, Göbel, Rachner, Fuessel, Froehner, Muders, Baretton, Bernhardt, Jakob, Glüer, Bornhäuser, Rauner, Hofbauer: WNT5A has anti-prostate cancer effects in vitro and reduces tumor growth in the skeleton in vivo. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015
Dog (Canine) Polyclonal WNT5A Primary Antibody for IHC (p), WB - ABIN675760
Saha, Aranda, Hayakawa, Bhanja, Atay, Brodin, Li, Asfaha, Liu, Tailor, Zhang, Godwin, Tome, Wang, Guha, Pollard: Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury. in Nature communications 2016
Human Monoclonal WNT5A Primary Antibody for ELISA, IHC - ABIN4366183
Prgomet, Andersson, Lindberg: Optimization, validation, and identification of two reliable antibodies for immunodetection of WNT5A. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2017
Human Polyclonal WNT5A Primary Antibody for IHC, IHC (p) - ABIN4892681
Zerboni, Sung, Lee, Arvin: Age-Associated Differences in Infection of Human Skin in the SCID Mouse Model of Varicella-Zoster Virus Pathogenesis. in Journal of virology 2018
WNT5A gene silencing reverses vincristine resistance in SKOV3/VCR cells possibly through blocking the PI3K/Akt/GSK3beta/beta-catenin signaling pathway, and thus down-regulating the protein expression levels of MDR1 and Survivin.
Wnt5a signaling results in acyl protein thioesterase 1 mediated depalmitoylation of pro-metastatic cell adhesion molecules CD44 and MCAM, resulting in increased melanoma invasion.
results of study of WNT5A expression at the transcript and protein levels indicate that it could be considered as a potential marker of molecular changes that take place during EC development.
This study reveals that the recruitment of DOCK2 may be critical for the capacity of Wnt5a to enhance CLL proliferation, which may contribute to the observed increased tendency for disease progression in patients who have CLL cells that express high levels of ROR1.
Identify SFRP5 as a novel vasodilative adipokine that induces endothelial NO production by antagonizing the WNT5A/JNK signaling pathway. Elevated serum SFRP5 concentration was significantly associated with arterial stiffness in human subjects with type 2 diabetes mellitus
High WNT5A expression is associated with Aldosterone-Producing Adenomas.
Cortactin plays an important role in ROR1-dependent Wnt5a-enhanced CLL-cell migration.
results suggest that WNT5A supports viability during both cell proliferation and osteogenic differentiation ofdental follicle cells.
WNT5A is produced by the choroid plexus of the developing hindbrain, but not the telencephalon, in both mouse and human.
Our results suggest that exosomal miR-92a-3p regulates cartilage development and homeostasis by directly targeting WNT5A. This indicates that exosomal miR-92a-3p may act as a Wnt inhibitor and exhibits potential as a disease-modifying osteoarthritis drug.
we provide evidence for the possibility of autosomal recessive inheritance in association with WNT5A loss-of-function mutations in RS.
Results show that WNT5A induces castration resistance in prostate cancer (CRPC) cells and suggest that WNT5A may be a key gene that induces CRPC in the bone niche by recruiting and regulating macrophages through CCL2 and BMP6, respectively.
overexpression of Wnt5a in UM-UC-3 cells significantly increased cell viability, while knock-down of Wnt5a by its siRNA in SW780 cells dramatically sensitized cells to gemcitabine. Our results identified Wnt5a as a target gene of miR-129-5p.
miR-16-2* is negative correlated with bone formation and downregulated during osteogenic differentiation. WNT5A is a direct target gene of miR-16-2*.
Study shows that Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy (DCM) patients and may promote the progression of DCM through NFAT signaling.
Impaired Wnt5a signaling is associated with poor placentation and subsequent development of preeclampsia.
Decreased hepatic Wnt5a signaling is associated with hepatocellular carcinoma progression and poor prognosis.
Annotation of rs11918967 in WNT5A in tissues might be related to obesity.
Wnt5a expression is critical for proliferation of RL and VZ progenitors and Purkinje cell dendritogenesis during early embryonic development resulting in retarded development of cerebellum during postnatal stages.
Study shows that Wnt5a is upregulated in invasive glioblastoma tissues, and demonstrates that it may regulate the invasion of glioblastoma cells, at least in part via the Daam1/RhoA signaling pathway.
In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a, acted across many cell diameters to orient Prickle3/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2, which require Wnt5a/Ror2 signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC signaling via RhoA and Wnt5a/Ror2 activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 binds syndecan 4 and that together they activate Wnt5a/PCP signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC by XWnt-5A requires the receptor tyrosine kinase Ror2.
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt/JNK signaling
WNT5A is a negative regulator of FSH-stimulated granulosa cell steroidogenesis in cattle.
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
Overall, our study unveils the prevalence of a Wnt5A-Rac1-Disheveled-mediated actin-associated autophagy circuit as an important component of innate immunity in host macrophages that may turn out crucial for restricting infection by leading bacterial pathogens.
Wnt5a promotes kidney fibrosis by stimulating Yap/Taz (Wwtr1)-mediated macrophage M2 polarization
treatment with MSC-anti-miR-92a-3p-Exos repressed chondrogenic differentiation and reduced cartilage matrix synthesis by enhancing the expression of WNT5A. Luciferase reporter assay demonstrated that miR-92a-3p suppressed the activity of a reporter construct containing the 3'-UTR and inhibited WNT5A expression in both MSCs and PHCs. MSC-miR-92a-3p-Exos inhibit cartilage degradation in the OA mice model.
Identification of ISL1 transcriptional targets via ChIP-Seq and expression analyses revealed that Isl1 regulates several important signaling pathways during embryonic genital development, including the BMP, WNT, and FGF cascades.
Study shows that the interplay between CYR61-CTGF-NOV1 (CCN1) and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy. Data highlight the significance of CCN1-EC and CCN1-pericyte communication signals in driving physiological and pathological angiogenesis.
Activating effect of WNT5A regulated bone formation in response to hindlimb unloading in mice, and pretreatment with WNT5A partly rescued the osteoporosis caused by mechanical unloading.
The results of this study indicated that Shh, Sfrp1, and Wnt5a collaborate to direct the pathfinding of descending 5-HT axons in the brainstem.
calcineurin is a key regulator of Wnt5a-induced AQP2 activation without affecting intracellular cAMP level and PKA activity.
The findings demonstrate that induction of Vangl protein phosphorylation plays an essential role in transducing Wnt5a signaling to establish Planar cell polarity (PCP) in mammalian development, suggesting a phosphorylation-regulated "Vangl activity gradient" model in addition to the well-documented "Fz activity gradient" model in Wnt/PCP signaling.
Post-mitotic filopodial "pathfinding" is guided by mesenchymal WNT5A. Without WNT5A, some cells fail to tether basally and undergo apoptosis, leading to a shortened midgut.
We demonstrate with genetic evidence that the Wnt5a gradient acts as a global cue that is instructive in establishing planar cell polarity (PCP) in the limb mesenchyme, and that Wnt5a also plays a permissive role to allow Fgf4 and Fgf8 signaling to orient PCP.
Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.
These data suggest that Wnt5a modulates the development of arthritis by promoting inflammation and osteoclast fusion, and provide the first mouse genetic evidence of a role for endogenous Wnt5a in autoimmune disease.
Here, we show that deletion of a single Wnt family member, Wnt5a, is sufficient to elicit profound disruptions in synaptic plasticity, structural maintenance, and learning and memory in adult mice, identifying the importance of this particular noncanonical Wnt in later-life functions.
Wnt5a promotes IL-6 and TIMP-1 release from mouse cardiac fibroblasts.
bivalent histone codes during odontogenic differentiation
WNT5A promoted spermatogonial stem cells activity both in vitro and in vivo.
results indicate that Wnt5a signaling restricts infection by antimony drug-sensitive and -resistant Leishmania donovani strains, at least in part by prohibiting parasite niche formation within host macrophages
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
, protein Wnt-5a
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A
, wingless-type MMTV integration site family, member 5A
, protein Wnt-5a-like
, cell signaling molecule Wnt-5