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Fibroblast Activation Protein, alpha Proteins (FAP)

The protein encoded by FAP is a homodimeric integral membrane gelatinase belonging to the serine protease family. Additionally we are shipping Fibroblast Activation Protein, alpha Antibodies (143) and Fibroblast Activation Protein, alpha Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FAP 14089 P97321
FAP 2191 Q12884
Rat FAP FAP 192203  
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Top Fibroblast Activation Protein, alpha Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$437.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Mouse His tag   1 mg Log in to see 56 to 66 Days
$4,229.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FAP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
,
Human , , , ,
, , ,

Top referenced Fibroblast Activation Protein, alpha Proteins

  1. Human FAP Protein expressed in Human Cells - ABIN3218781 : Aertgeerts, Levin, Shi, Snell, Jennings, Prasad, Zhang, Kraus, Salakian, Sridhar, Wijnands, Tennant: Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha. in The Journal of biological chemistry 2005 (PubMed)
    Show all 3 references for ABIN3218781

More Proteins for Fibroblast Activation Protein, alpha (FAP) Interaction Partners

Cow (Bovine) Fibroblast Activation Protein, alpha (FAP) interaction partners

  1. Soluble form of a seprase activity is detected in bovine serum

  2. We clearly show an association between FAPalpha and chondrocytes in the context of cartilage degradation. (Fibroblast activation protein alpha)

Mouse (Murine) Fibroblast Activation Protein, alpha (FAP) interaction partners

  1. In two different models of pulmonary fibrosis, intratracheal bleomycin instillation and thoracic irradiation, the study finds increased mortality and increased lung fibrosis in FAP-deficient mice compared with wild-type mice.

  2. Mouse FGF-21 (show FGF21 Proteins), however, lacks the FAP cleavage site and is not cleaved by FAP.

  3. Data indicate that indolamine-2,3-dioxygenase (IDO (show IDO1 Proteins)) and Fibroblast activation protein alpha (FAPalpha) were detectable in B16 melanoma tumor-bearing mice.

  4. A transgenic mouse model for pulmonary fibrosis was generated. After bleomycin induction, luciferase cDNA under the control of the FAPa promoter presents strong luminescence in the lungs especially; the expression level reflects the degree of the disease.

  5. Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase (show MUL1 Proteins) and glomulin (GLMN (show GLMN Proteins)).

  6. The FAP(+) stromal cell may have roles in two adverse consequences of cancer.

  7. In NIH 3T3 cells overexpressing recombinant mouse FAP, FAP enzymatic activity during matrix production is important for the topographical organization of the ECM (show MMRN1 Proteins) fibers.

  8. Authors conclude that the proteolytic activity of FAP participates in matrix degradation, but other functions of the protein stimulate increased tumor growth.

  9. FAP may be a potentially useful marker for wound age determination.

  10. Results suggest that FAP, a product preferentially expressed by TAF, could function as an effective tumor rejection antigen.

Human Fibroblast Activation Protein, alpha (FAP) interaction partners

  1. NPY is efficiently cleaved by FAP indicating a potential function for FAP in neuropeptide regulation within liver and cancer biology.

  2. degradomic study highlights cell-contextual proteolysis by FAPalpha with distinct positional profiles. Generally, our findings link FAPalpha to key aspects of CAF (show KAT2B Proteins) biology and attribute an important role in tumor-stroma interaction to FAPalpha

  3. Data suggest that a DNA vaccine targeting human fibroblast activation protein alpha (FAPalpha) may be an attractive and effective cancer immunotherapy strategy.

  4. In this study, we show for the first time the expression of FAP in activated fibroblasts after MI and its activation by TGFbeta1 (show TGFB1 Proteins). Effects of FAP on fibroblast migration and gelatinolytic activity indicate a potential role in cardiac wound healing

  5. FAP is expressed by activated, collagen-synthesizing fibroblasts, but not by inactive fibroblasts or fully differentiated myofibroblasts and non-fibroblast cells in the infarct.

  6. This study identified fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21 (show FGF21 Proteins).

  7. Human FGF-21 (show FGF21 Proteins) Is a Substrate of Fibroblast Activation Protein.

  8. FAP selectively cleaves type I collagen resulting in increased macrophage adhesion.

  9. FAP sensitizes fibrosarcoma to chemotherapy and alters cell death.

  10. Data show that FAP and DPP4 (show DPP4 Proteins) proteins were simultaneously induced in dedifferentiating mature adipocytes supporting a potential role for these enzymes in adipose tissue remodeling and cell plasticity.

Fibroblast Activation Protein, alpha (FAP) Protein Profile

Protein Summary

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

Gene names and symbols associated with FAP

  • fibroblast activation protein, alpha (fap-A)
  • fibroblast activation protein, alpha (FAP)
  • fibroblast activation protein, alpha (fap)
  • fibroblast activation protein (Fap)
  • fibroblast activation protein, alpha (Fap)
  • glomulin, FKBP associated protein (Glmn)
  • 9330160J16Rik protein
  • AW227515 protein
  • DPPIV protein
  • FAP protein
  • fap-A protein
  • Fap48 protein
  • Fap68 protein
  • FAPA protein
  • gene 13 protein
  • seprase protein

Protein level used designations for FAP

fibroblast activation protein, alpha , fibroblast activation protein, alpha subunit , seprase , gene 13 , seprase-like , fibroblast activation protein alpha , integral membrane serine protease , 170 kDa melanoma membrane-bound gelatinase , FAP , FK506-binding protein-associated protein , FKBP-associated protein , glomulin

GENE ID SPECIES
378554 Xenopus laevis
424186 Gallus gallus
459691 Pan troglodytes
508882 Bos taurus
608176 Canis lupus familiaris
100022372 Monodelphis domestica
100051480 Equus caballus
100082270 Ornithorhynchus anatinus
100134993 Xenopus (Silurana) tropicalis
100392684 Callithrix jacchus
100437836 Pongo abelii
100547273 Meleagris gallopavo
100553731 Anolis carolinensis
100606225 Nomascus leucogenys
14089 Mus musculus
2191 Homo sapiens
192203 Rattus norvegicus
170823 Mus musculus
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