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IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. Additionally we are shipping Interleukin 31 Antibodies (111) and Interleukin 31 Kits (54) and many more products for this protein.
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IL-31 affects keratinocyte differentiation in multiple ways and the IL-1 (show IL1A Proteins) cytokine network is a major downstream effector of IL-31 signaling in deregulating the physical skin barrier.
Oncostatin M (show OSM Proteins) and interleukin-31: Cytokines, receptors, signal transduction and physiology.
The results of our analyses regarding serum levels and receptor expression do not suggest a central role of IL-31 in Mycosis fungoides/Sezary syndrome pathogenesis.
In summary, TGF-beta1 (show TGFB1 Proteins) and IL-31 were linked to progression from chronic hepatitis B to liver cirrhosis, and correlated well with the severity of disease.
An increase of IL-31 serum levels in postmenopausal women with decreased bone mineral density, is shown.
a possible systemic involvement of IL-31 and the absence of a systemic involvement of IL-33 (show IL33 Proteins) in allergic contact dermatitis.
crucial requirements for IL-31 signaling and its counter-regulation by SOCS3 (show SOCS3 Proteins)
IL-31 expression in allergic rhinitis aggravated and amplified Th2 inflammation as well as mucin (show SLC13A2 Proteins) production
The IL-31 serum level was significantly higher in cutaneous T-cell lymphoma patients than in the control group but there were no positive correlation between IL-31 serum level and pruritus.
IL-31 is overexpressed in the lesional skin of LP but its expression does not correlate with intensity of pruritus.
IL-31 upregulates IL-31RA (show IL31RA Proteins) expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA (show IL31RA Proteins) expression in mice
our results suggest a functional cooperation between NFAT1 (show NFAT1 Proteins) and JunB (show JUNB Proteins) in mediating IL-31 gene expression in CD4 (show CD4 Proteins)(+) T cells
Data not only illustrate various functions that cysteines perform during IL-31 biosynthesis and secretion, but also highlight their potential roles in cytokine effector functions.
IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases
IL-31 interaction with IL-31 receptor (IL-31R) is identified in an acute model of T helper cell type 2 inflammation in the lung.
these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine.
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004