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anti-Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Antibodies

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH1 Proteins (14) and IDH1 Kits (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IDH1 3417 O75874
IDH1 15926 O88844
IDH1 24479 P41562
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Top anti-IDH1 Antibodies at antibodies-online.com

Showing 10 out of 189 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB Sample type: 1. HEPG2 (50ug)2. Drosophila extract (50ug)Primary dilution: 1:1000Secondary Antibody: mouse anti-Rabbit HRPSecondary Dilution: 1:5000Image Submitted by: Xinyang BingLaurentian University 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of IDH1 Antibody (N-term) (ABIN391659) in mouse liver tissue and 293 cell line lysates (35 µg/lane). IDH1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain reacted with IDH1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with IDH1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of IDH1 Antibody (Center) (ABIN391660) in HepG2 cell line and mouse liver tissue lysates (35 µg/lane). IDH1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, IHC, WB Immunohistochemical staining of paraffin-embedded breast tissue using anti-IDH1 mouse monoclonal antibody. (ABIN2452633, Dilution 1:50) Immunohistochemical staining of paraffin-embedded colon tissue using anti-IDH1 mouse monoclonal antibody. (ABIN2452633, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IP, IHC (p), WB IP Image IDH-1 antibody immunoprecipitates IDH-1 protein in IP experiments. IP Sample: HepG2 whole cell lysate/extract A : 30 μg whole cell lysate/extract of IDH1 protein expressing HepG2 cells B : Control with 2.5 μg of pre-immune rabbit IgG C : Immunoprecipitation of IDH-1 protein by 2.5 μg of IDH-1 antibody , 10% SDS-PAGE The immunoprecipitated IDH-1 protein was detected by IDH-1 antibody , diluted at 1 : 1000. EasyBlot anti-mouse IgG (HRP)  was used as a secondary reagent. WB Image IDH1 antibody detects IDH1 protein by western blot analysis. A. 30 μg 293T whole cell lysate/extract B. 30 μg HeLa whole cell lysate/extract C. 30 μg HepG2 whole cell lysate/extract 10 % SDS-PAGE IDH1 antibody , dilution: 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Yeast Goat Un-conjugated EIA, WB AP31099PU-N IDH1 antibody staining of S. cerevisiae lysate at 0.5 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

IDH1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-IDH1 Antibodies

  1. Human Polyclonal IDH1 Primary Antibody for FACS, IF - ABIN391660 : Geisbrecht, Gould: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. in The Journal of biological chemistry 1999 (PubMed)
    Show all 2 references for ABIN391660

  2. Human Polyclonal IDH1 Primary Antibody for FACS, IF - ABIN391659 : Xu, Zhao, Xu, Peng, Huang, Arnold, Ding: Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN391659

  3. Cow (Bovine) Polyclonal IDH1 Primary Antibody for IHC, WB - ABIN2785883 : Kullberg, Nilsson, Arnason, Harley, Janke: Housekeeping genes for phylogenetic analysis of eutherian relationships. in Molecular biology and evolution 2006 (PubMed)
    Show all 2 references for ABIN2785883

  4. Human Monoclonal IDH1 Primary Antibody for IF, IHC - ABIN2452633 : Elhammali, Ippolito, Collins, Crowley, Marasa, Piwnica-Worms: A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor. in Cancer discovery 2014 (PubMed)

More Antibodies against IDH1 Interaction Partners

Human Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Data indicate a significant effect only in one scenario, the interaction between temozolomide (TMZ) and R132H mutations in isocitrate dehydrogenase (IDH1) on the overall survival of lower-grade glioma (LGG)

  2. alterations in genetic regulatory mechanisms may be the key factor for the major phenotypic changes in IDH1 mutated gliomas

  3. Data show that the monitoring of isocitrate dehydrogenase (NADP(+)) 1/2 IDH1/2 mutations showed that these mutations were reliable minimal residual disease (MRD) markers that allowed the prediction of relapse in the majority of patients.

  4. Case Report: right cerebellar pilocytic astrocytoma WHO grade I with an IDH1 R132H mutation.

  5. Data indicate that isocitrate dehydrogenase (NADP(+)) 1 (IDH1) mutation is a positive prognostic marker for low-grade glioma patients.

  6. Mutations in IDH1 gene conferred resistance to Temozolomide in glioblastoma.

  7. The combined use of IDH1 mutation and MGMT (show MGMT Antibodies) methylation status can be used as prognostic markers for long-term survival of patients with cerebral low-grade glioma.

  8. mmunohistochemistry can be used for evaluation of ATRX (show ATRX Antibodies) loss, p53 (show TP53 Antibodies) protein accumulation and IDH1R132H mutation, which may allow a means of classification of astrocytoma outcome

  9. Mutations in isocitrate dehydrogenase 1 with high d-2-hydroxyglutarate serum levels are associated with acute myeloid leukemia (show BCL11A Antibodies).

  10. IDH1 mutations are associated with myelodysplastic syndromes.

Mouse (Murine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells

  2. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH (show FDXR Antibodies) ratio.

  3. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.

  4. MiR (show MLXIP Antibodies)-181a regulates lipid metabolism via IDH1

  5. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.

  6. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.

  7. WA might exert its chemopreventive activity via inhibiting not only oncogenic activation, but also IDH1 inactivation.

  8. Brain-specific (show CALY Antibodies) Idh1-KI mice show brain hemorrhage accompanied by high D2HG levels but decreased ROS (show ROS1 Antibodies)

  9. Suggest that decreased IDPc expression renders melanocytes more vulnerable to oxidative stress, and IDPc plays an important antioxidant function in melanocytes.

  10. Absence of IDH1 mutations in low-grade gliomas (LGGs) identifies a novel entity of LGGs with distinctive location, infiltrative behavior, specific molecular alterations, and dismal outcome.

Cow (Bovine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.

Pig (Porcine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)

  3. These results suggest that IDPm (show IDH2 Antibodies) plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Antibodies) activity.

IDH1 Antigen Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Gene names and symbols associated with IDH1

  • isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) antibody
  • isocitrate dehydrogenase 1 (NADP+), soluble (Idh1) antibody
  • isocitrate dehydrogenase 1 (NADP+), soluble (idh1) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) antibody
  • AI314845 antibody
  • AI788952 antibody
  • cb876 antibody
  • E030024J03Rik antibody
  • fm90e09 antibody
  • Id-1 antibody
  • IDCD antibody
  • IDH antibody
  • Idh-1 antibody
  • IDP antibody
  • Idpc antibody
  • im:7143416 antibody
  • NADP-CICDH antibody
  • PICD antibody
  • wu:fm90e09 antibody

Protein level used designations for IDH1

isocitrate dehydrogenase 1 (NADP+), soluble , isocitrate dehydrogenase [NADP] cytoplasmic-like , NADP(+)-specific ICDH , NADP-dependent isocitrate dehydrogenase, cytosolic , NADP-dependent isocitrate dehydrogenase, peroxisomal , isocitrate dehydrogenase [NADP] cytoplasmic , oxalosuccinate decarboxylase , IDH , IDP , cytosolic NADP-isocitrate dehydrogenase , isocitrate dehydrogenase 1 , Isocitrate dehydrogenase 1, soluble , ICD-M , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase [NADP], mitochondrial

GENE ID SPECIES
478889 Canis lupus familiaris
751618 Felis catus
100414768 Callithrix jacchus
3417 Homo sapiens
15926 Mus musculus
494713 Xenopus laevis
100328559 Oryctolagus cuniculus
24479 Rattus norvegicus
281235 Bos taurus
100006589 Danio rerio
100170146 Sus scrofa
443257 Ovis aries
397603 Sus scrofa
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