anti-Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Antibodies

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH1 Kits (20) and IDH1 Proteins (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IDH1 3417 O75874
IDH1 15926 O88844
IDH1 24479 P41562
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Top anti-IDH1 Antibodies at antibodies-online.com

Showing 10 out of 207 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>Sample type:</b> 1. HEPG2 (50ug)<br>2. Drosophila extract (50ug)<br><b>Primary dilution:</b> 1:1000<br><b>Secondary Antibody:</b> mouse anti-Rabbit HRP<br><b>Secondary Dilution:</b> 1:5000<br><b>Image Submitted by:</b> Xinyang Bing<br>Laurentian University 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of IDH1 Antibody (N-term) (ABIN391659) in mouse liver tissue and 293 cell line lysates (35 µg/lane). IDH1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain reacted with IDH1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with IDH1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of IDH1 Antibody (Center) (ABIN391660) in HepG2 cell line and mouse liver tissue lysates (35 µg/lane). IDH1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, IHC, WB Immunohistochemical staining of paraffin-embedded breast tissue using anti-IDH1 mouse monoclonal antibody. (ABIN2452633, Dilution 1:50) Immunohistochemical staining of paraffin-embedded colon tissue using anti-IDH1 mouse monoclonal antibody. (ABIN2452633, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Goat Un-conjugated ELISA, WB Western Blot: Isocitrate Dehydrogenase 1/IDH1 Antibody [NBP1-52118] - Analysis of Isocitrate dehydrogenase (aa153-164) in HepG2 lysate (35ug protein in RIPA buffer) using NBP1-52118 at 0.3 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry: Isocitrate Dehydrogenase 1/IDH1 Antibody [NBP1-87428] - Immunohistochemical staining of human prostate shows strong cytoplasmic and nuclear positivity in glandular cells. Western Blot: Isocitrate Dehydrogenase 1/IDH1 Antibody [NBP1-87428] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IP, WB Western Blot: Isocitrate dehydrogenase Antibody [NBP2-32150] - Samples: Whole cell lysate (50 ug) from K562, HeLa, 293T, mouse TCMK-1, mouse NIH3T3, and rat C6 cells. Antibodies: Affinity purified rabbit anti-Isocitrate dehydrogenase antibody NBP2-32150 used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. Immunoprecipitation: Isocitrate dehydrogenase Antibody [NBP2-32150] - Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-Isocitrate dehydrogenase antibody NBP2-32150 used for IP at 6 ug/mg lysate. For blotting immunoprecipitated Isocitrate dehydrogenase, NBP2-32150 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Goat Un-conjugated ELISA, WB Western Blot: Isocitrate Dehydrogenase 1/IDH1 Antibody [NBP1-52119] - Analysis of Isocitrate dehydrogenase (aa65-77) in HepG2 lysate (35ug protein in RIPA buffer) using NBP1-52119 at 0.1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details

IDH1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-IDH1 Antibodies

  1. Human Monoclonal IDH1 Primary Antibody for IF, IHC - ABIN2452633 : Elhammali, Ippolito, Collins, Crowley, Marasa, Piwnica-Worms: A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor. in Cancer discovery 2014 (PubMed)

  2. Human Polyclonal IDH1 Primary Antibody for ELISA, WB - ABIN4327714 : Abbas, Lugthart, Kavelaars, Schelen, Koenders, Zeilemaker, van Putten, Rijneveld, Löwenberg, Valk: Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. in Blood 2010 (PubMed)

  3. Human Polyclonal IDH1 Primary Antibody for IHC, IHC (p) - ABIN4327716 : ODwyer, Ralton, OShea, Murray: The proteomics of colorectal cancer: identification of a protein signature associated with prognosis. in PLoS ONE 2011 (PubMed)

  4. Human Polyclonal IDH1 Primary Antibody for IP, WB - ABIN4327718 : Abdel Malik, Zippel, Frömel, Heidler, Zukunft, Walzog, Ansari, Pampaloni, Wingert, Rieger, Wittig, Fisslthaler, Fleming: AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis. in Circulation research 2016 (PubMed)

  5. Cow (Bovine) Polyclonal IDH1 Primary Antibody for IHC, WB - ABIN2785883 : Kullberg, Nilsson, Arnason, Harley, Janke: Housekeeping genes for phylogenetic analysis of eutherian relationships. in Molecular biology and evolution 2006 (PubMed)
    Show all 2 Pubmed References

More Antibodies against IDH1 Interaction Partners

Human Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. IDH mutations define a distinct subtype of ICC, a malignancy that is largely refractory to current therapies. Our work demonstrates that IDHm (show IDH2 Antibodies) ICC cells are hypersensitive to dasatinib and critically dependent on SRC (show SRC Antibodies) activity for survival and proliferation, pointing to new therapeutic strategies against these cancers.

  2. Mutations in the IDH1 and IDH2 (show IDH2 Antibodies) genes perturb the epigenome through cytosine methylation, histone post-translational modifications and transcription factors. [review]

  3. Profiled 4400 freshly isolated single cells from isocitrate IDH1-mutant oligodendrogliomas and 7500 single cells from IDH1-mutant astrocytomas by RNA-seq. Found that irrespective of their histologic subclassification into astrocytic or oligodendroglial tumors, all IDH1 mutant gliomas share a similar cellular architecture that is distinct from IDH1 wild-type gliomas.

  4. IDH1 mutation is associated with high-grade gliomas.

  5. six out of six recurrent and IDH1 mutated grade III tumors also showed XAF1 (show XAF1 Antibodies) promoter methylation

  6. IDH1 R132C mutation is associated with clear cell hepatocellular carcinoma.

  7. Identification of IDH1 or IDH2 (show IDH2 Antibodies) mutations supports the diagnosis of dedifferentiated chondrosarcoma rather than undifferentiated pleomorphic sarcoma of bone.

  8. The data of this study suggested that mutant IDH1 has potent antithrombotic activity within gliomas and throughout the peripheral circulation.

  9. This retrospective analysis suggested that the presence of an IDH1 (R132H) mutation, frontal tumor location, and WHO grade of the initial tumor are associated with OS after progression to secondary glioblastoma.

  10. Expression of mutant IDH1 suppresses the accumulation of T cells in glioma tumor sites.

Mouse (Murine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system.

  2. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis

  3. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM (show ATM Antibodies) by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC (show FUT1 Antibodies) self-renewal, independent of TET2 (show TET2 Antibodies).

  4. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1 (show ACO1 Antibodies), enzymes involved in the TCA cycle, were elevated.

  5. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells

  6. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

  7. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.

  8. MiR (show MLXIP Antibodies)-181a regulates lipid metabolism via IDH1

  9. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.

  10. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.

Cow (Bovine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.

Pig (Porcine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)

  3. These results suggest that IDPm (show IDH2 Antibodies) plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Antibodies) activity.

IDH1 Antigen Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Gene names and symbols associated with IDH1

  • isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) antibody
  • isocitrate dehydrogenase 1 (NADP+), soluble (Idh1) antibody
  • isocitrate dehydrogenase 1 (NADP+), soluble (idh1) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) antibody
  • AI314845 antibody
  • AI788952 antibody
  • cb876 antibody
  • E030024J03Rik antibody
  • fm90e09 antibody
  • Id-1 antibody
  • IDCD antibody
  • IDH antibody
  • Idh-1 antibody
  • IDP antibody
  • Idpc antibody
  • im:7143416 antibody
  • NADP-CICDH antibody
  • PICD antibody
  • wu:fm90e09 antibody

Protein level used designations for IDH1

isocitrate dehydrogenase 1 (NADP+), soluble , isocitrate dehydrogenase [NADP] cytoplasmic-like , NADP(+)-specific ICDH , NADP-dependent isocitrate dehydrogenase, cytosolic , NADP-dependent isocitrate dehydrogenase, peroxisomal , isocitrate dehydrogenase [NADP] cytoplasmic , oxalosuccinate decarboxylase , IDH , IDP , cytosolic NADP-isocitrate dehydrogenase , isocitrate dehydrogenase 1 , Isocitrate dehydrogenase 1, soluble , ICD-M , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase [NADP], mitochondrial

GENE ID SPECIES
478889 Canis lupus familiaris
751618 Felis catus
100414768 Callithrix jacchus
3417 Homo sapiens
15926 Mus musculus
494713 Xenopus laevis
100328559 Oryctolagus cuniculus
24479 Rattus norvegicus
281235 Bos taurus
100006589 Danio rerio
100170146 Sus scrofa
443257 Ovis aries
397603 Sus scrofa
Selected quality suppliers for anti-IDH1 (IDH1) Antibodies
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