Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH1 Kits (18) and IDH1 Proteins (15) and many more products for this protein.
Showing 10 out of 199 products:
Cow (Bovine) Polyclonal IDH1 Primary Antibody for IHC, WB - ABIN2785883
Kullberg, Nilsson, Arnason, Harley, Janke: Housekeeping genes for phylogenetic analysis of eutherian relationships. in Molecular biology and evolution 2006
Show all 2 references for ABIN2785883
Human Polyclonal IDH1 Primary Antibody for FACS, IF - ABIN391659
Geisbrecht, Gould: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. in The Journal of biological chemistry 1999
Show all 2 references for ABIN391659
Human Polyclonal IDH1 Primary Antibody for FACS, IF - ABIN391660
Xu, Zhao, Xu, Peng, Huang, Arnold, Ding: Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. in The Journal of biological chemistry 2004
Show all 2 references for ABIN391660
Human Polyclonal IDH1 Primary Antibody for IHC, IHC (p) - ABIN4327716
ODwyer, Ralton, OShea, Murray: The proteomics of colorectal cancer: identification of a protein signature associated with prognosis. in PLoS ONE 2011
Human Polyclonal IDH1 Primary Antibody for IP, WB - ABIN4327718
Abdel Malik, Zippel, Frömel, Heidler, Zukunft, Walzog, Ansari, Pampaloni, Wingert, Rieger, Wittig, Fisslthaler, Fleming: AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis. in Circulation research 2016
Human Polyclonal IDH1 Primary Antibody for ELISA, WB - ABIN4327714
Abbas, Lugthart, Kavelaars, Schelen, Koenders, Zeilemaker, van Putten, Rijneveld, Löwenberg, Valk: Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. in Blood 2010
Human Monoclonal IDH1 Primary Antibody for IF, IHC - ABIN2452633
Elhammali, Ippolito, Collins, Crowley, Marasa, Piwnica-Worms: A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor. in Cancer discovery 2014
the contribution of IDH1 and IDH2 (show IDH2 Antibodies) mutations to gliomagenesis[review]
Allograft tumor assays in mice demonstrate that this mechanism contributes to tumorigenesis driven by mutant IDH1, a result confirmed by detection of JNK (show MAPK8 Antibodies) inactivation in human gliomas harboring IDH1-R132H mutations.
Data show that patients with MGMT (show MGMT Antibodies) protein promoter methylation and isocitrate dehydrogenase 1 (IDH1) somatic mutation had a better prognosis than those with MGMT (show MGMT Antibodies) methylation alone.
Multivariate analysis by Cox (show COX8A Antibodies) proportional hazard regression model demonstrated that lack of IDH1 mutation was an independent prognostic factor for both progression- and disease-specific survival in patients with astrocytomas and oligodendrogliomas
IDH1(R132H) mutation occurs only exceptionally in pituitary adenomas and does not play a role in their pathogenesis.
review examines mutant IDH1/2 and TET2 (show TET2 Antibodies) enzymes in the context of responses to DNA damage and their potential involvement in age-related genomic instability.
IDH1 mutation is related with preoperative seizure in low-grade gliomas.
Our results suggest that the pathogenesis of multicentric gliomas is different from the mutant IDH1-R132H pathogenesis of lower-grade glioma and secondary glioblastomas.
IDH1 mutation is associated with pseudoprogression and predicts a longer median survival in GBM patients after TMZ-based chemoradiotherapy.
The study confirmed the importance of the IDH1/2 mutation and hypermethylation of the MGMT (show MGMT Antibodies) gene promoter being present in brain Glioma tissue.
Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1 (show ACO1 Antibodies), enzymes involved in the TCA cycle, were elevated.
data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells
The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH (show FDXR Antibodies) ratio.
These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.
MiR (show MLXIP Antibodies)-181a regulates lipid metabolism via IDH1
revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.
these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.
WA might exert its chemopreventive activity via inhibiting not only oncogenic activation, but also IDH1 inactivation.
Brain-specific (show CALY Antibodies) Idh1-KI mice show brain hemorrhage accompanied by high D2HG levels but decreased ROS (show ROS1 Antibodies)
Suggest that decreased IDPc expression renders melanocytes more vulnerable to oxidative stress, and IDPc plays an important antioxidant function in melanocytes.
Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.
Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)
analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)
These results suggest that IDPm (show IDH2 Antibodies) plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Antibodies) activity.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.
isocitrate dehydrogenase 1 (NADP+), soluble
, isocitrate dehydrogenase [NADP] cytoplasmic-like
, NADP(+)-specific ICDH
, NADP-dependent isocitrate dehydrogenase, cytosolic
, NADP-dependent isocitrate dehydrogenase, peroxisomal
, isocitrate dehydrogenase [NADP] cytoplasmic
, oxalosuccinate decarboxylase
, cytosolic NADP-isocitrate dehydrogenase
, isocitrate dehydrogenase 1
, Isocitrate dehydrogenase 1, soluble
, NADPH-specific isocitrate dehydrogenase
, isocitrate dehydrogenase [NADP], mitochondrial