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Lymphocyte-Activation Gene 3 Proteins (LAG3)

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. Additionally we are shipping Lymphocyte-Activation Gene 3 Antibodies (185) and Lymphocyte-Activation Gene 3 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LAG3 16768 Q61790
LAG3 3902 P18627
LAG3 297596 Q5BK54
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Top Lymphocyte-Activation Gene 3 Proteins at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human HIS-GST 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
$651.00
Details
HOST_CHO Human Fc Tag   50 μg Log in to see 5 to 8 Days
$367.50
Details
HOST_CHO Human Fc Tag   50 μg Log in to see 5 to 8 Days
$425.25
Details

LAG3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , , , ,
, , ,
Human , , , , , ,
, , , , ,
Rat (Rattus) , ,

Top referenced Lymphocyte-Activation Gene 3 Proteins

  1. Human LAG3 Protein expressed in CHO - ABIN1344459 : Huard, Prigent, Tournier, Bruniquel, Triebel: CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins. in European journal of immunology 1995 (PubMed)
    Show all 6 references for ABIN1344459

  2. Rat (Rattus) LAG3 Protein expressed in Human Cells - ABIN2009550 : Baixeras, Huard, Miossec, Jitsukawa, Martin, Hercend, Auffray, Triebel, Piatier-Tonneau: Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. in The Journal of experimental medicine 1992 (PubMed)
    Show all 3 references for ABIN2009550

  3. Human LAG3 Protein expressed in HEK-293 Cells - ABIN2181447 : Triebel, Jitsukawa, Baixeras, Roman-Roman, Genevee, Viegas-Pequignot, Hercend: LAG-3, a novel lymphocyte activation gene closely related to CD4. in The Journal of experimental medicine 1990 (PubMed)
    Show all 2 references for ABIN2181447

  4. Human LAG3 Protein expressed in CHO - ABIN1344460 : Cappello, Triebel, Iezzi, Caorsi, Quaglino, Lollini, Amici, Di Carlo, Musiani, Giovarelli, Forni: LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice. in Cancer research 2003 (PubMed)

More Proteins for Lymphocyte-Activation Gene 3 (LAG3) Interaction Partners

Cow (Bovine) Lymphocyte-Activation Gene 3 (LAG3) interaction partners

Rhesus Monkey Lymphocyte-Activation Gene 3 (LAG3) interaction partners

  1. We show that the expression of LAG3 is highly induced in the lungs and particularly in the granulomatous lesions of macaques experimentally infected with mycobacterium tuberculosis.

Mouse (Murine) Lymphocyte-Activation Gene 3 (LAG3) interaction partners

  1. An IL-27 (show IL27 Proteins)/Lag3 axis enhances Foxp3 (show FOXP3 Proteins)+ regulatory T cell-suppressive function and therapeutic efficacy.

  2. LAG3 and PD1 (show PDCD1 Proteins) co-inhibitory molecules have roles in collaborating to limit CD8 (show CD8A Proteins)+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model

  3. Poxvirus-Based Active Immunotherapy with PD-1 (show PDCD1 Proteins) and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice.

  4. Lymphatic endothelial cells (LECs) serve as an antigen reservoir for CD4 (show CD4 Proteins) T-cell tolerance, and MHC-II molecules on LECs are used to induce CD8 (show CD8A Proteins) T-cell tolerance via LAG-3.

  5. LAG-3 expression on Tconv cells makes them more susceptible to Treg based suppression, and also regulates the development of a TH1 (show HAND1 Proteins) T-cell response.

  6. LAG-3 exerts an important regulatory effect on autoimmunity.

  7. Lag-3 is an important regulatory molecule involved in alloreactive T cell proliferation and activation after bone marrow transplantation.

  8. these results define a strong synergy between the PD-1 (show PDCD1 Proteins) and LAG-3 inhibitory pathways in tolerance to both self and tumor antigens.

  9. We conclude that LAG-3 is necessary for regulating CD4 (show CD4 Proteins)(+) and CD8 (show CD8A Proteins)(+) T cell function during autoimmune diabetes

  10. LAG-3 is required for long-term peripheral CD8 (show CD8A Proteins) but not CD4 (show CD4 Proteins) T-cell tolerance and this requirement is CD8 (show CD8A Proteins) cell-extrinsic.

Human Lymphocyte-Activation Gene 3 (LAG3) interaction partners

  1. An IL-27 (show IL27 Proteins)/Lag3 axis enhances Foxp3 (show FOXP3 Proteins)+ regulatory T cell-suppressive function and therapeutic efficacy.

  2. LAG-3 is highly expressed in peripheral blood CD8 (show CD8A Proteins)+ T cells in chronic HBV-infected patients.

  3. Data indicate that in recurrent spontaneous abortion patients, the expression levels of CD49b (show ITGA2 Proteins) and LAG-3 (CD223) on CD14 (show NDUFA2 Proteins)(+) mononuclear cells and the plasma level of transforming growth factor beta (TGF-beta) decreased obviously compared with normal females.

  4. iNKT cytokine production is profoundly altered by both HIV infection and treatment, and LAG-3, but not PD-1 (show PDCD1 Proteins), expression is associated with a reduction in iNKT IFNgamma production.

  5. NFKB1 (show NFKB1 Proteins), CD27 (show CD27 Proteins), LAG3 and IKZF3 (show IKZF3 Proteins) are new susceptibility genes for psoriasis.

  6. The elevated expression of LAG-3 at the genital tract suggests it may regulate T-cell activation, and identify cells susceptible to HIV infection. The enrichment of LAG-3 on double negative T cells suggests LAG-3 may contribute to the immunoregulatory activity of these cells.

  7. the LAG-3/MHC class II (show HLA-DPA1 Proteins) pathway may synergize with PD-1 (show PDCD1 Proteins)/PD ligand to enhance T cell-mediated immune responses.

  8. LAG-3 trafficking from lysosomal compartments to the cell surface is dependent on the cytoplasmic domain through protein kinase C signaling in activated T cells.

  9. These results suggest that LAG-3-mediated activation of plasmacytoid dendritic cells takes place in vivo at tumor sites, and it is in part responsible for directing an immune-suppressive environment.

  10. Expression of LAG-3 is coincident with the impaired effector function of HBV-specific CD8 (show CD8A Proteins)(+) T cell in HCC (show FAM126A Proteins) patients.

Lymphocyte-Activation Gene 3 (LAG3) Protein Profile

Protein Summary

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

Gene names and symbols associated with LAG3

  • lymphocyte-activation gene 3 (LAG3)
  • lymphocyte-activation gene 3 (Lag3)
  • CD223 protein
  • LAG-3 protein
  • Ly66 protein

Protein level used designations for LAG3

lymphocyte-activation gene 3 , lymphocyte-activation protein 3 , lymphocyte-activation protein 3-like , lymphocyte activation gene 3 protein-like , lymphocyte activation gene 3 protein , LAG-3 , lymphocyte activation gene 3

GENE ID SPECIES
418287 Gallus gallus
451794 Pan troglodytes
515155 Bos taurus
713737 Macaca mulatta
100059998 Equus caballus
100415501 Callithrix jacchus
100452007 Pongo abelii
16768 Mus musculus
3902 Homo sapiens
297596 Rattus norvegicus
100125962 Sus scrofa
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