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anti-MDS1 and EVI1 Complex Locus (MECOM) Antibodies

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. Additionally we are shipping MDS1 and EVI1 Complex Locus Proteins (8) and MDS1 and EVI1 Complex Locus Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MECOM 2122 Q03112,Q13465
MECOM 14013 Q9Z1L8
MECOM 294924  
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Top anti-MDS1 and EVI1 Complex Locus Antibodies at antibodies-online.com

Showing 10 out of 117 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Human Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of EVI1 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the EVI1 antibody detected the EVI1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-MDS1 Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: Raji cell lysate WB Suggested Anti-MDS1  Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500  Positive Control: Raji cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of MDS1 Antibody (Center) in mouse NIH-3T3 cell line lysates (35ug/lane). This demonstrates the MDS1 antibody detected the MDS1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated EIA, WB AP23733PU-N MECOM antibody staining of A549 lysate at 2 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated WB Western analysis of extracts from 293 cells using PRDM3 antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details

MECOM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine)
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Rat (Rattus)


Top referenced anti-MDS1 and EVI1 Complex Locus Antibodies

  1. Human Polyclonal MECOM Primary Antibody for EIA, WB - ABIN952135 : Gómez-Benito, Conchillo, García, Vázquez, Maicas, Vicente, Cristobal, Marcotegui, García-Ortí, Bandrés, Calasanz, Alonso, Odero: EVI1 controls proliferation in acute myeloid leukaemia through modulation of miR-1-2. in British journal of cancer 2010 (PubMed)
    Show all 2 references for ABIN952135

  2. Human Polyclonal MECOM Primary Antibody for EIA, WB - ABIN953364 : Goyama, Kurokawa: Evi-1 as a critical regulator of leukemic cells. in International journal of hematology 2010 (PubMed)
    Show all 2 references for ABIN953364

  3. Chicken Polyclonal MECOM Primary Antibody for IHC, WB - ABIN2777403 : Chi, Senyuk, Chakraborty, Nucifora: EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity. in The Journal of biological chemistry 2003 (PubMed)

  4. Human Polyclonal MECOM Primary Antibody for WB - ABIN2780631 : Fears, Mathieu, Zeleznik-Le, Huang, Rowley, Nucifora: Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)

  5. Chicken Polyclonal MECOM Primary Antibody for WB - ABIN2787657 : Sato, Goyama, Nitta, Takeshita, Yoshimi, Nakagawa, Kawazu, Ichikawa, Kurokawa: Evi-1 promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-b signaling. in Cancer science 2008 (PubMed)

More Antibodies against MDS1 and EVI1 Complex Locus Interaction Partners

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 Antibodies) signaling

  2. Prdm3 and prdm16 (show PRDM16 Antibodies) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. MECOM deletion is associated with congenital thrombocytopenia.

  2. ETV6 (show ETV6 Antibodies)/RUNX1 (show RUNX1 Antibodies) transcript is a target of RNA-binding protein (show PTBP1 Antibodies) IGF2BP1 (show IGF2BP1 Antibodies) in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia.

  3. Runx1 (show RUNX1 Antibodies) haploinsufficiency appears to predispose FPD patients to MM by expanding the pool of stem/progenitor cells and blocking myeloid differentiation in response to G-CSF (show CSF3 Antibodies).

  4. RUNX1 (show RUNX1 Antibodies) haploinsufficiency collaborates with genetic alterations conferring clonal advantage such as TET2 (show TET2 Antibodies) mutation or trisomy 21 to establish pre-leukemic state.

  5. involvement of MECOM in patients with acute myeloid leukemia (show BCL11A Antibodies) and myelodysplastic syndrome with various 3q abnormalities

  6. The study shows a low representation of ETV6 (show ETV6 Antibodies)-RUNX1 (show RUNX1 Antibodies) fusion oncogenes among pediatric acute lymphoblastic leukemia patients from King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.

  7. Germline RUNX1 (show RUNX1 Antibodies) mutations are associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia (show BCL11A Antibodies).

  8. Two novel translocations leading to the inactivation of RUNX1 (show RUNX1 Antibodies) and its partners SIN3A (show SIN3A Antibodies) and TCF12 (show TCF12 Antibodies) in myeloid leukemia (show BCL11A Antibodies).

  9. RUNX1-Evi-1 (show RUNX1 Antibodies) may promote proliferation and apoptosis resistance of primitive hematopoietic cell, and inhibit the differentiation of myeloid cells with the synergy of different pathways and factors.

  10. Thus, an NGF (show NGFB Antibodies)/TrkA (show NTRK1 Antibodies)-MAPK (show MAPK1 Antibodies)-CBFbeta (show CBFB Antibodies) pathway converges with Islet1 (show ISL1 Antibodies)-Runx1 (show RUNX1 Antibodies) signaling to promote Runx1 (show RUNX1 Antibodies)/CBFbeta (show CBFB Antibodies) holocomplex formation and nonpeptidergic nociceptor maturation.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 Antibodies), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 Antibodies) levels.

  2. Survivin (show BIRC5 Antibodies) partially regulates HSC (show FUT1 Antibodies) function by modulating the Evi-1 transcription factor and its downstream targets

  3. Thrombopoietin (show THPO Antibodies)/MPL (show MPL Antibodies) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  4. Prdm16 (show PRDM16 Antibodies) and Prdm3 control postnatal BAT (show BAAT Antibodies) identity and function.

  5. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  6. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL Antibodies)) fusion protein (MFP) leukemia

  7. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (show CEBPB Antibodies), liver inhibitory protein (LIP), induced acute myeloid leukemia (show BCL11A Antibodies) with short latencies in a mouse bone marow transplantation model.

  8. Transient Evi1 transfection inhibited TGF-beta-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta in MC-26 mouse colon cancer cells.

  9. Evi1 is a key regulator of adipogenic competency

  10. Data identify Prdm3 and Prdm16 (show PRDM16 Antibodies) as H3K9me1 methyltransferases and expose a functional framework in which anchoring to the nuclear periphery helps maintain the integrity of mammalian heterochromatin.

MDS1 and EVI1 Complex Locus (MECOM) Antigen Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) antibody
  • MDS1 and EVI1 complex locus (MECOM) antibody
  • MDS1 and EVI1 complex locus (LOC100343228) antibody
  • MDS1 and EVI1 complex locus (Mecom) antibody
  • runt-related transcription factor 1 (RUNX1) antibody
  • AML1 antibody
  • AML1-EVI-1 antibody
  • AMLCR1 antibody
  • CBFA2 antibody
  • D630039M04Rik antibody
  • EVI-1 antibody
  • Evi1 antibody
  • im:7140716 antibody
  • Jbo antibody
  • Mds antibody
  • Mds1 antibody
  • Mds1-Evi1 antibody
  • PEBP2aB antibody
  • Prdm3 antibody
  • Znfpr1b1 antibody

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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