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anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) Antibodies

PICALM encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. Additionally we are shipping Phosphatidylinositol Binding clathrin Assembly Protein Kits (13) and Phosphatidylinositol Binding clathrin Assembly Protein Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PICALM 289668 Q68FS4
PICALM 8301 Q13492
PICALM 233489 Q7M6Y3
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Top anti-Phosphatidylinositol Binding clathrin Assembly Protein Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PICALM in EL4 cell lysate with this product at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Biotin FACS, ICFC 500 μg Log in to see 10 to 12 Days
$298.95
Details
Mouse Mouse Biotin FACS, CyTOF 500 μg Log in to see 10 to 12 Days
$298.95
Details
Mouse Mouse APC FACS 100 μg Log in to see 10 to 12 Days
$320.68
Details
Mouse Mouse PerCP-Cy5.5 FACS, CyTOF, IP, IHC, WB 100 μg Log in to see 10 to 12 Days
$320.68
Details
Human Mouse FITC BCA 100 Tests Log in to see 10 to 12 Days
$266.33
Details
Human Mouse PE FACS 100 Tests Log in to see 10 to 12 Days
$298.95
Details

PICALM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Phosphatidylinositol Binding clathrin Assembly Protein Antibodies

  1. Mouse (Murine) Monoclonal PICALM Primary Antibody for FACS, CyTOF - ABIN2660221 : Oida, Weiner: TGF-? induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction. in PLoS ONE 2010 (PubMed)
    Show all 8 references for ABIN2660221

  2. Mouse (Murine) Monoclonal PICALM Primary Antibody for FACS, CyTOF - ABIN2660795 : Miyazono, Ichijo, Heldin: Transforming growth factor-beta: latent forms, binding proteins and receptors. in Growth factors (Chur, Switzerland) 1993 (PubMed)
    Show all 7 references for ABIN2660795

  3. Mouse (Murine) Monoclonal PICALM Primary Antibody for FACS - ABIN2658361 : Nakamura, Kitani, Strober: Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. in The Journal of experimental medicine 2001 (PubMed)
    Show all 7 references for ABIN2658361

  4. Human Monoclonal PICALM Primary Antibody for BCA - ABIN2661958 : Yi, Barnes, Hand, Polleux, Ehlers: TGF-beta signaling specifies axons during brain development. in Cell 2010 (PubMed)
    Show all 4 references for ABIN2661958

  5. Human Monoclonal PICALM Primary Antibody for FACS - ABIN2662783 : Khalil: TGF-beta: from latent to active. in Microbes and infection / Institut Pasteur 2000 (PubMed)
    Show all 4 references for ABIN2662783

  6. Human Monoclonal PICALM Primary Antibody for FACS, ICFC - ABIN2660780 : Lu, Munger, Steadele, Busald, Tellier, Schnapp: Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. in Journal of cell science 2002 (PubMed)
    Show all 4 references for ABIN2660780

  7. Human Polyclonal PICALM Primary Antibody for EIA, WB - ABIN500493 : Tebar, Bohlander, Sorkin: Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. in Molecular biology of the cell 1999 (PubMed)

More Antibodies against Phosphatidylinositol Binding clathrin Assembly Protein Interaction Partners

Fruit Fly (Drosophila melanogaster) Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) interaction partners

  1. results reveal a new mode by which AP180 couples protein retrieval to CME of SVs (show FGFR2 Antibodies)

  2. clathrin adapter protein (show GRB10 Antibodies)

Human Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) interaction partners

  1. PICALM and CLU (show CLU Antibodies) risk genotypes exert differential impacts on the hippocampal resting-state functional connectivity in healthy young subjects.

  2. PICALM has a role in modulating autophagy activity and tau accumulation

  3. the rs541458 and rs3851179 of PICALM SNPs are not related to development of behavioral and psychological symptoms of dementia in Turkish population

  4. We detected a significant association of the MTHFR (show MTHFR Antibodies) rs1801133 and PICALM rs3851179 polymorphisms with AD.

  5. PICALM SNP is significantly associated with late onset Alzheimer disease.

  6. CALM is a major factor in controlling endocytic clathrin-coated vesicle size and maturation and hence in determining the rates of endocytic cargo uptake.

  7. Data suggest a neural mechanism for APOE (show APOE Antibodies)-PICALM interactions in patients with manifest Alzheimer's disease and indicate that the PICALM genotype modulates both brain atrophy and cognitive performance in APOE (show APOE Antibodies) epsilon4 carrier

  8. multiple PICALM isoforms are expressed in the human brain, that PICALM is robustly expressed in microvessels, and that expression of total PICALM is modestly correlated with the AD-associated SNP rs3851179.

  9. allelic expression has shown that compelling PICALM allelic expression imbalance was not observed in most brain RNA samples

  10. physical activity attenuated the effects of genetic risk (ie. the constellation of PICALM, BIN1 (show BIN1 Antibodies), and CLU (show CLU Antibodies) polymorphisms) on episodic memory

Mouse (Murine) Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) interaction partners

  1. Confinement within the presynaptic bouton is mediated in part by synaptic vesicle protein association with the clathrin-based endocytic machinery to limit diffusional spread of newly exocytosed SV proteins.

  2. the PICALM PIP2 binding domain is necessary for transferrin receptor endocytosis in erythroblasts and absolutely essential for erythroid development from mouse hematopoietic stem/progenitor cells in an erythroid culture system.

  3. During leukemogenesis, CALM-AF10 (show MLLT10 Antibodies) plays critical roles in the cytoplasm.

  4. These data reveal that PICALM plays a critical role in iron homeostasis.

  5. PICALM, an adaptor protein involved in clathrin-mediated endocytosis, regulates APP (show APP Antibodies) internalization and subsequent Abeta (show APP Antibodies) generation. PICALM contributes to amyloid plaque load in brain likely via its effect on Abeta (show APP Antibodies) metabolism.

  6. These results indicate that CALM is required for erythroid maturation and transferrin (show Tf Antibodies) internalization in mice.

  7. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin

  8. the Rarb (show RARB Antibodies) region of Mmu14 and Stmn2 (show STMN2 Antibodies), but not Cr1 (show TDGF1 Antibodies) or Clu (show CLU Antibodies) or Picalm have roles in prion (show PRNP Antibodies) disease

  9. fit14R & fit15R are nonsense point mutations in the mouse PICALM gene. They are splice-donor alterations causing transcripts less abundant transcripts missing exons 4 & 17, respectively. The protein is truncated near the N or C termini, respectively.

Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) Antigen Profile

Protein Summary

This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10\;11)(p13\;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PICALM

  • like-AP180 (lap) antibody
  • leucine aminopeptidase 3 (Lap3) antibody
  • phosphatidylinositol binding clathrin assembly protein (PICALM) antibody
  • phosphatidylinositol binding clathrin assembly protein (Picalm) antibody
  • AP180 antibody
  • BcDNA:GM10787 antibody
  • Calm antibody
  • CG2520 antibody
  • CLTH antibody
  • dAP-3 antibody
  • Dmel\\CG2520 antibody
  • EP(3)3060 antibody
  • EP3060 antibody
  • fit-1 antibody
  • fit1 antibody
  • l(3)neo34 antibody
  • Lap antibody
  • LAP-3 antibody
  • lap/AP180 antibody
  • mKIAA4114 antibody
  • PAP180 antibody
  • sig antibody

Protein level used designations for PICALM

CG2520-PA , CG2520-PC , CG2520-PD , CG2520-PE , CG2520-PF , CG2520-PG , CG2520-PH , CG2520-PI , CG2520-PJ , EP3060 , Like-AP180 , complementation group 12 , lap-PA , lap-PC , lap-PD , lap-PE , lap-PF , lap-PG , lap-PH , lap-PI , lap-PJ , like AP180 , saisoog , LAP , cytosol aminopeptidase , leucyl aminopeptidase , proline aminopeptidase , prolyl aminopeptidase , clathrin assembly lymphoid myeloid leukemia protein , phosphatidylinositol-binding clathrin assembly protein , clathrin assembly lymphoid myeloid leukemia , clathrin-assembly lymphoid leukemia protein , clathrin-assembly lymphoid myeloid leukemia protein , rCALM

GENE ID SPECIES
40863 Drosophila melanogaster
289668 Rattus norvegicus
8301 Homo sapiens
233489 Mus musculus
89816 Rattus norvegicus
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