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Prickle Homolog 1 (Drosophila) Proteins (PRICKLE1)

PRICKLE1 encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. Additionally we are shipping PRICKLE1 Antibodies (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRICKLE1 144165 Q96MT3
PRICKLE1 106042 Q3U5C7
Rat PRICKLE1 PRICKLE1 315259  
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Top PRICKLE1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

PRICKLE1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Prickle Homolog 1 (Drosophila) (PRICKLE1) Interaction Partners

Human Prickle Homolog 1 (Drosophila) (PRICKLE1) interaction partners

  1. these findings suggest PRICKLE1 mutations contribute to ASD (show ARSD Proteins) by disrupting the interaction with SYN1 (show SYN1 Proteins) and regulation of synaptic vesicles.

  2. study demonstrates that PRICKLE1 could act as a predisposing factor to human neural tube defects

  3. MINK1 interacts with and phosphorylates PRICKLE1 and PRICKLE2.

  4. Mutations in prickle1 causes seizures.

  5. PRICKLE1 mutations are not a frequent cause of progressive myoclous epilepsies in Southern Italy.

  6. PRICKLE1 and PRICKLE2 mRNAs were expressed together in brain, eye and testis.

  7. appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors

  8. NRSF/REST functions as a repressor of TH transcription in NSCs via a mechanism dependent on the TH NRSE/RE1 (show NPC2 Proteins) sites.

  9. Prickle-1 is a negative regulator of the Wnt/beta-catenin signaling pathway and is a putative tumor suppressor in human hepatocellular carcinoma

  10. there is synergism between REST and NFkappaB (show NFKB1 Proteins) in the suppression of TAC1 (show TAC1 Proteins) in non-neuronal cells

Mouse (Murine) Prickle Homolog 1 (Drosophila) (PRICKLE1) interaction partners

  1. Prickle1 is part of a molecular mechanism that regulates facial branchiomotor neurons caudal migration.

  2. these findings suggest PRICKLE1 mutations contribute to ASD (show GUSB Proteins) by disrupting the interaction with SYN1 (show SYN1 Proteins) and regulation of synaptic vesicles.

  3. Data suggest Prickle1 is part of the Wnt5a (show WNT5A Proteins)/PCP (show BMP1 Proteins) signaling, regulating cell polarity and affecting expression of multiple factors to stunt limb growth through altered patterns of gene expression, including the PCP (show BMP1 Proteins) genes Wnt5a (show WNT5A Proteins) and Vangl2 (show VANGL2 Proteins).

  4. Pk1 function in axonal-dendritic development associated with the maturation of CNS neurons.

  5. Prickle1 and Prickle2 promote neurite-like process formation of C1300 cells via the Dvl1 (show DVL1 Proteins)-dependent mechanism

  6. These results suggest that RILP(also known as Prickle) expression and function control REST action more so than does REST expression and is an important regulatory role in cardiomyocyte differentiation.

  7. Mutations in prickle1 causes seizures.

  8. both Prickle1 and Prickle2 promote neurite-like process formation of C1300 neuroblastoma (show ARHGEF16 Proteins) cells via the Dishevelled (show DVL2 Proteins) dependent pathway

  9. mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development

  10. Results demonstrate a role for prickle1 in AB polarity formation rather than expected role as a PCP (show BMP1 Proteins) gene.

PRICKLE1 Protein Profile

Protein Summary

This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.

Gene names and symbols associated with PRICKLE1

  • prickle homolog 1 (Drosophila) (PRICKLE1)
  • prickle homolog 1 (Drosophila) (Prickle1)
  • 1110058P22Rik protein
  • AW215793 protein
  • EPM1B protein
  • mpk1 protein
  • Prickle protein
  • Rilp protein

Protein level used designations for PRICKLE1

prickle-like 1 , prickle-like protein 1 , REST/NRSF-interacting LIM domain protein 1 , REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein , prickle like 1

GENE ID SPECIES
451838 Pan troglodytes
701864 Macaca mulatta
144165 Homo sapiens
106042 Mus musculus
315259 Rattus norvegicus
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