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RUNX3 encodes a member of the runt domain-containing family of transcription factors. Additionally we are shipping RUNX3 Proteins (11) and RUNX3 Kits (4) and many more products for this protein.
Showing 10 out of 218 products:
Human Polyclonal RUNX3 Primary Antibody for EMSA - ABIN3434042
Peng, Wei, Wang, Tang, Zhang, Le, Jia, Li, Xie: RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Show all 6 Pubmed References
Human Monoclonal RUNX3 Primary Antibody for ICS, IHC (p) - ABIN2689899
Chuang, Ito, Ito: RUNX family: Regulation and diversification of roles through interacting proteins. in International journal of cancer. Journal international du cancer 2013
Show all 6 Pubmed References
Human Polyclonal RUNX3 Primary Antibody for ELISA, WB - ABIN560191
Nakamura, Senzaki, Yoshikawa, Nishimura, Inoue, Ito, Ozaki, Shiga: Dynamic regulation of the expression of neurotrophin receptors by Runx3. in Development (Cambridge, England) 2008
Show all 5 Pubmed References
Human Monoclonal RUNX3 Primary Antibody for CyTOF, FACS - ABIN4899364
Chopin, Seillet, Chevrier, Wu, Wang, Morse, Belz, Nutt: Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks. in The Journal of experimental medicine 2013
Show all 2 Pubmed References
Human Monoclonal RUNX3 Primary Antibody for ICC, FACS - ABIN1724742
Mei, Bai, Liu, Li, Wu, Yu, Zheng: RUNX3 expression is lost in glioma and its restoration causes drastic suppression of tumor invasion and migration. in Journal of cancer research and clinical oncology 2011
Human Polyclonal RUNX3 Primary Antibody for IF, IHC (p) - ABIN658684
Zhu, Xu, Hu, Feng, Jiang, Hou, Cao, Han, Ling, Ge: Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma. in Journal of experimental & clinical cancer research : CR 2015
Human Polyclonal RUNX3 Primary Antibody for IF, IHC (p) - ABIN514065
Shi, Wang, Liu, Chen: Inactivation of RUNX3 predicts poor prognosis in esophageal squamous cell carcinoma after Ivor-Lewis esophagectomy. in Medical oncology (Northwood, London, England) 2014
In neuronal fate determination, Runx co-factor Cbfbeta (show CBFB Antibodies) is essential for its function, but the high level of Runx3 expression can overcome the loss of Cbfbeta (show CBFB Antibodies), demonstrating that Cbfbeta (show CBFB Antibodies) in this context serves solely as a signal amplifier of Runx3 activity.
successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish
Runx3 expression leads to an increase in primitive blood cell numbers, together with an increase in runx1 (show RUNX1 Antibodies)-expressing cells in the ventral wall of the dorsal aorta.
Zebrafish embryos lacking Rad21 (show RAD21 Antibodies), or cohesin subunit Smc3 (show SMC3 Antibodies), fail to express runx3 and lose hematopoietic runx1 (show RUNX1 Antibodies) expression in early embryonic development.
These results demonstrate that the CRISPR/Cas9 system is effective in inducing mutations on a specific locus of genome and the RUNX3 knockout pigs can be useful resources for human cancer research and to develop novel cancer therapies.
The findings suggest that the absence of uPA (show PLAU Antibodies) correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.
Runx3-deficient CD8 (show CD8A Antibodies)(+) cytotoxic effector T cells aberrantly upregulated genes characteristic of follicular helper T (TFH) cell lineage, including Bcl6 (show BCL6 Antibodies), Tcf7 (show TCF7 Antibodies) and Cxcr5 (show CXCR5 Antibodies). Mechanistically, the Runx3-CBFbeta (show CBFB Antibodies) transcription factor complex deployed H3K27me3 to Bcl6 (show BCL6 Antibodies) and Tcf7 (show TCF7 Antibodies) genes to suppress the TFH program.
Deletion of Runx3 in the peripheral nervous system or specifically in peripheral sensory neurons, or of enhancer elements driving Runx3 expression in proprioceptive neurons, induced prepubertal scoliosis.
We found that Runx3 exerted a positive effect on early myeloid development
Runx3 plays a crucial role in the hypothalamo-pituitary-gonadal axis
intricate combinatorial interplay among the three regulatory elements governs Runx3 expression in distinct subtypes of TrkC (show NTRK3 Antibodies) neurons while concomitantly extinguishing its expression in non-TrkC (show NTRK3 Antibodies) neurons
this study identifies a compensatory signaling mechanism that prevents lineage-fate errors by dynamically modulating Runx3d induction rates during MHC I positive selection
our data suggest that Runx3 may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 (show NTRK3 Antibodies) variants
Runx3 is crucial for the phenotypic and functional changes observed in ThPok (show ZBTB7B Antibodies)-deficient invariant natural killer T cells.
the transcription factor Runx3 was essential for the normal development of subsets of innate lymphoid cells (ILCs) in the mucosa
RUNX3 mRNA and protein expression were upregulated in nasal-type extranodal NK/T-cell lymphoma (NKTL) patient samples and NKTL cell lines compared to normal NK cells. RUNX3 silenced NKTL cells showed increased apoptosis and reduced cell proliferation. MYC (show MYC Antibodies) and RUNX3 binding occurs. Potential binding sites for MYC (show MYC Antibodies) were identified in the RUNX3 enhancer region.
The methylation status of Runx3 gene are abnormal in Hepatocellular Carcinoma patients, which may further be used as molecular markers for early diagnosis of Liver cancer.
RUNX 3 hypermethylation is associated with breast cancer.
High RUNX3 expression is associated with gastric cancer.
we present evidence that RUNX3 can act as a tumor suppressor in a human T-cell malignancy and suggest that this effect is predominantly mediated through transcripts from its distal promoter, in particular RUNX3/p46 (show POLDIP3 Antibodies).
Our results from clinical samples also suggest that Threonine 209 phosphorylation by Pak1 (show PAK1 Antibodies) could be a potential therapeutic target and of great clinical relevance with implications for Runx3 inactivation in cancer cells where Runx3 is known to be oncogenic. The findings presented in this study provide evidence of Runx3-Threonine 209 phosphorylation as a molecular switch in dictating the tissue-specific dualistic functions
RUNX3 acts as a tumour suppressor
MicroRNA-145 could regulate the balance of Th1 (show TH1L Antibodies)/Th2 through targeting the RUNX3 in asthma patients.
The miR (show MLXIP Antibodies)-29b/KDM2A (show KDM2A Antibodies) axis was involved in the RUNX3-mediated inhibition of gastric cancer cell proliferation and metastasis.
RUNX3 methylation level is associated with gastric cancer (GC), especially the methylation at site -1415 contributes to the poor prognosis in GC.
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
runt-related transcription factor b
, runt-related transcription factor 3
, core-binding factor 3
, PEA2-alpha C
, PEBP2-alpha C
, SL3-3 enhancer factor 1 alpha C subunit
, SL3/AKV core-binding factor alpha C subunit
, acute myeloid leukemia 2 protein
, core binding factor alpha 3
, core-binding factor subunit alpha-3
, oncogene AML-2
, polyomavirus enhancer-binding protein 2 alpha C subunit
, runt domain, alpha subunit 3
, transcription factor AML2/CBFA3
, PEA2 alpha C
, PEBP2 alpha C
, acute myeloid leukemia gene 2
, core-binding factor, runt domain, alpha subunit 3
, transcription factor AML2
, Runt related transcription factor 3
, Runx3 MASN-variant