anti-SMAD, Mothers Against DPP Homolog 5 (SMAD5) Antibodies

The protein encoded by SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. Additionally we are shipping SMAD5 Proteins (14) and SMAD5 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMAD5 4090 Q99717
SMAD5 17129 P97454
SMAD5 59328 Q9R1V3
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Top anti-SMAD5 Antibodies at

Showing 10 out of 110 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-SMAD5 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>HepG2 cell lysate WB Suggested Anti-SMAD5 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB Western blot analysis of SMAD5 expression in HeLa (A), mouse testis (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
Human Rabbit Un-conjugated WB SMAD5 Antibody (Center) (ABIN1881816) pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate. SMAD5 Antibody (Center) (arrow) was detected using the purified Pab. 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Flow cytometric analysis of Jurkat cells using SMAD5 mouse mAb (green) and negative control (purple) . Figure 2: Immunofluorescence analysis of NTERA-2 cells using SMAD5 mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC (p), WB Anti-SMAD5 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti-SMAD5 antibody, IHC(P) IHC(P): Rat Intestine Tissue 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Uterus, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using SMAD5, antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with  (Red) at 1:2000. 100 μL Log in to see 1 to 2 Days
Dog Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
Human Mouse Un-conjugated ELISA, FACS, ICC, IF, IHC (p), WB 100 μL Log in to see 7 to 9 Days

SMAD5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
, , , , ,
Mouse (Murine) , ,
Rat (Rattus) ,

Top referenced anti-SMAD5 Antibodies

  1. Human Polyclonal SMAD5 Primary Antibody for WB - ABIN1881816 : Park, Lee, Ahn, Kim: Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity. in Molecular bioSystems 2009 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal SMAD5 Primary Antibody for ICC, FACS - ABIN969404 : Chang, Chang, Lee, Lee, Yeh, Yeh, Cheng, Chien, Chiu: Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 2 Pubmed References

More Antibodies against SMAD5 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.

  2. Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.

  3. Data show that interplay of Smad1 (show SMAD1 Antibodies)/5 and MAP kinase (show MAPK1 Antibodies) signaling system (ERK (show MAPK1 Antibodies) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.

  4. this study uncovers that smad1 (show SMAD1 Antibodies) and smad9 (show SMAD9 Antibodies) act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.

  5. Functional investigation of a subset of these genes, fgf10a (show FGF10 Antibodies), tgfb2 (show TGFB2 Antibodies), pax9 (show PAX9 Antibodies), and smad5 revealed their necessity in zebrafish palatogenesis.

  6. maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2 (show BMP4 Antibodies)/7 signaling to establish the initial dorsoventral asymmetry

  7. Data show that patterning of the eye primordia in Smad5-deficient embryos starts during blastula and early gastrula stages.

  8. that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 (show SMAD1 Antibodies) and Smad5.

  9. Data show that Smad5 expression is ubiquitous during testis development but becomes cell-specific in the adult.

Human SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. Here the involvement of the pathway in adult brain function is suggested. This exploratory study establishes a strategy to better identify neuronal molecular signatures that are potentially associated with mental illness and cognitive deficits. We propose that the SMAD (show SMAD1 Antibodies) pathway may be a novel target in addressing cognitive deficit of SZ in future studies.

  2. the BMP-2 (show BMP2 Antibodies)/Smad1 (show GARS Antibodies)/5/RUNX2 (show RUNX2 Antibodies) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (show BGLAP Antibodies) synth

  3. miR (show MLXIP Antibodies)-23a and miR (show MLXIP Antibodies)-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL (show FASL Antibodies)-Fas (show FAS Antibodies) pathway

  4. Our findings suggest that suppression of miR (show MLXIP Antibodies)-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 (show RUNX2 Antibodies) signaling axis.

  5. Overexpression of the BMP4 (show BMP4 Antibodies)/SMAD4 (show SMAD4 Antibodies)/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.

  6. The polycomb group protein L3MBTL1 (show L3MBTL1 Antibodies) represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.

  7. adult human Sertoli cells assumed similar morphological features, stable global gene expression profiles and numerous proteins, and activation of AKT (show AKT1 Antibodies) and SMAD1 (show GARS Antibodies)/5 during long-period culture.

  8. balance between Smad1 (show GARS Antibodies)/5- and Smad2 (show SMAD2 Antibodies)/3-dependent signaling defines the outcome of the effect of TGF-beta (show TGFB1 Antibodies) on atherosclerosis where Smad1 (show GARS Antibodies)/5 is responsible for proatherogenic effects

  9. among the 15 SNPs, rs3206634 was significantly associated with KD in a recessive model (odds ratio = 2.31, p = 0.019), whereas there was no association between any of the 15 SNPs and CALs (show CA8 Antibodies).

  10. Our results indicated that KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4 (show SMAD4 Antibodies)/smad5 pathway.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (show RUNX2 Antibodies)) expression through S1PR2 (show S1PR2 Antibodies)/RhoA (show RHOA Antibodies)/ROCK/Smad1 (show SMAD1 Antibodies)/5/8 signaling.

  2. We discovered that Smad1 (show SMAD1 Antibodies)/5/4-Amhr2 (show AMHR2 Antibodies)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1 (show SMAD1 Antibodies)/5/4-Amhr2 (show AMHR2 Antibodies)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.

  3. these studies characterize an accessory TGF-beta (show TGFB1 Antibodies)-stimulated BMP R-Smad (show SMAD1 Antibodies) signaling mechanism in interstitial cells of the developing lung.

  4. Thyroid-specific Smad1 (show SMAD1 Antibodies) and Smad5 double-knockout (Smad1 (show SMAD1 Antibodies)/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.

  5. Smad1 (show SMAD1 Antibodies) and Smad5 have overlapping functions to govern hepcidin (show HAMP Antibodies) transcription. Moreover, erythropoietin (show EPO Antibodies) and erythroferrone target Smad1 (show SMAD1 Antibodies)/5 signaling and require Smad1 (show SMAD1 Antibodies)/5 to suppress hepcidin (show HAMP Antibodies) expression.

  6. miR (show MLXIP Antibodies)-106b-5p and miR-17-5p are novel Smad5 regulators.

  7. BetA can enhance in vivo osteogenic potentials of BMP2 (show BMP2 Antibodies), possibly via stimulating Smad 1 (show SMAD1 Antibodies)/5/8 and p38 (show CRK Antibodies) pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.

  8. Data show that in R-Smad (show SMAD1 Antibodies) proteins Smad1 (show SMAD1 Antibodies);Smad5 knockout embryonic stem cells (mESCs), the bone morphogenetic proteins (BMP)-SMAD (show SMAD1 Antibodies) signaling is dispensable for self-renewal.

  9. Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).

  10. The crystal structure of Smad5-MH1 (show SCN5A Antibodies) domain in complex with a composite DNA sequence demonstrates that the MH1 (show SCN5A Antibodies) domain is targeted to a binding site with modular binding modes, and the length of the DNA spacer affects the MH1 (show SCN5A Antibodies) assembly.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

SMAD5 Antigen Profile

Protein Summary

The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with SMAD5

  • SMAD family member 5 (SMAD5) antibody
  • SMAD family member 5 (smad5) antibody
  • SMAD family member 4, gene 2 S homeolog (smad4.2.S) antibody
  • SMAD family member 5 (Smad5) antibody
  • 1110051M15Rik antibody
  • AI451355 antibody
  • DKFZp468M0619 antibody
  • dpc4 antibody
  • Dwf-C antibody
  • DWFC antibody
  • fb67b04 antibody
  • jip antibody
  • JV5-1 antibody
  • mad antibody
  • madh4 antibody
  • Madh5 antibody
  • MusMLP antibody
  • sb:cb400 antibody
  • SBN antibody
  • SMAD5 antibody
  • smad10 antibody
  • smd5 antibody
  • wu:fb67b04 antibody
  • xsmad4 antibody
  • XSmad4alpha antibody

Protein level used designations for SMAD5

mothers against decapentaplegic homolog 5 , SMA- and MAD-related protein 5 , SMAD 5 , SMAD family member 5 , mothers against DPP homolog 5 , pgy , piggytail , somitabun , MAD, mothers against decapentaplegic homolog 5 , SMAD, mothers against DPP homolog 5 , mothers against decapentaplegic, drosophila, homolog of, 5 , MAD homolog 5 , Smad 5 , dwarfin-C , mSmad5 , Mothers against decapentaplegic homolog 5

100033851 Equus caballus
30641 Danio rerio
403398 Xenopus laevis
4090 Homo sapiens
17129 Mus musculus
59328 Rattus norvegicus
395679 Gallus gallus
481520 Canis lupus familiaris
768050 Bos taurus
100173534 Pongo abelii
100303615 Sus scrofa
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