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anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) Antibodies

The protein encoded by SMAD6 belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. Additionally we are shipping SMAD6 Proteins (11) and SMAD6 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMAD6 4091 O43541
SMAD6 17130 O35182
SMAD6 367100  
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Top anti-SMAD6 Antibodies at antibodies-online.com

Showing 10 out of 141 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-SMAD6 Antibody Titration: 0.5-1.0ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SMAD6 Antibody Titration: 0.2-1 ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using SMAD6 mouse mAb against A431 (1), A431 (2), Hela (3) and Jurkat (4) cell lysate. 100 μL Log in to see 3 to 4 Days
$393.80
Details
Mouse Rabbit Un-conjugated WB SMAD6 Antibody (C-term) (ABIN1881817) western blot analysis in mouse Neuro-2a cell line lysates (35 µg/lane). This demonstrates the SMAD6 antibody detected the SMAD6 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated FACS, WB SMAD6 Antibody (Center) (ABIN651537) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the SMAD6 antibody detected the SMAD6 protein (arrow). SMAD6 Antibody (Center) (ABIN651537) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Testis (formalin-fixed, paraffin-embedded) stained with SMAD6 antibody ABIN295868 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB Anti-SMAD6 antibody, Western blotting Lane 1: Rat Kidney Tissue Lysate Lane 2: A549 Cell Lysate Lane 3: SMMC Cell Lysate Lane 4:  Cell Lysate 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$390.50
Details

SMAD6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SMAD6 Antibodies

  1. Human Monoclonal SMAD6 Primary Antibody for EIA, WB - ABIN1109064 : Shintani, Yagi, Nakayama, Saji, Matsuoka: A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension. in Journal of medical genetics 2009 (PubMed)
    Show all 3 references for ABIN1109064

  2. Human Monoclonal SMAD6 Primary Antibody for ELISA, WB - ABIN969405 : Shen, Chen, Wang, Kaneki, Xing, Okeefe, Chen: Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. in The Journal of biological chemistry 2006 (PubMed)
    Show all 3 references for ABIN969405

  3. Mouse (Murine) Polyclonal SMAD6 Primary Antibody for WB - ABIN1881817 : Ryan, Ryan, Fabre, Lawless, Crowe: Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis. in Hepatology (Baltimore, Md.) 2010 (PubMed)
    Show all 2 references for ABIN1881817

  4. Human Polyclonal SMAD6 Primary Antibody for WB - ABIN2792563 : Tsunobuchi, Ishisaki, Imamura: Expressions of inhibitory Smads, Smad6 and Smad7, are differentially regulated by TPA in human lung fibroblast cells. in Biochemical and biophysical research communications 2004 (PubMed)

More Antibodies against SMAD6 Interaction Partners

Human SMAD, Mothers Against DPP Homolog 6 (SMAD6) interaction partners

  1. Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer

  2. monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O (show UBE2O Antibodies) and SMAD6 cooperated in the regulation of BMP7 (show BMP7 Antibodies)-induced adipogenesis

  3. Smad6 indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells.

  4. Loss of SMAD6 is associated with lung adenocarcinoma.

  5. Congenital cardiovascular malformation is related to genetic variation in SMAD6

  6. Haplotype analysis further revealed that two haplotype blocks within SMAD6 were significantly associated with decreased ovarian cancer risk, as compared to the most common haplotype.

  7. results suggest that MyD88 (show MYD88 Antibodies) degradation driven by the Smad6-Smurf pathway is a novel mechanism for TGF-beta1 (show TGFB1 Antibodies)-mediated negative regulation of MyD88 (show MYD88 Antibodies)-dependent pro-inflammatory signalling

  8. Data show that Runx1 (show RUNX1 Antibodies), in conjunction with Fli1 (show FLI1 Antibodies), Gata2 (show GATA2 Antibodies), and Scl (show KRT7 Antibodies), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.

  9. Smad6 and Smad7, inhibitors of BMP signaling, were up-regulated in HFE-mutant hereditary hemochromatosis compared to controls, disruptin bone morphogenic protein signaling.

  10. Smad6 together with Smad2 (show SMAD2 Antibodies) may be prognostic factors, independent of nodal status in oral SCC (show CYP11A1 Antibodies) after curative resection

Mouse (Murine) SMAD, Mothers Against DPP Homolog 6 (SMAD6) interaction partners

  1. These results indicate that PRIP (show NCOA6 Antibodies) is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad (show SMAD1 Antibodies) phosphorylation, through the methylation of inhibitory Smad6

  2. These findings suggest that TNF-alpha (show TNF Antibodies) induces valvular and vascular cell calcification, in part, by specifically reducing the expression of a BMP-2 (show BMP2 Antibodies) signaling inhibitor, Smad6.

  3. The Smad6 is a novel target of Arkadia (show RNF111 Antibodies), and that Arkadia (show RNF111 Antibodies) positively regulates BMP signalling via degradation of Smad6, Smad7 (show SMAD7 Antibodies) and c-Ski (show SKI Antibodies)/SnoN (show SKIL Antibodies).

  4. Smad6 inhibits non-canonical TGF-beta1 (show TGFB1 Antibodies) signaling by recruiting the deubiquitinase A20 (show TNFAIP3 Antibodies) to TRAF6 (show TRAF6 Antibodies).

  5. monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O (show UBE2O Antibodies) and SMAD6 cooperated in the regulation of BMP7 (show BMP7 Antibodies)-induced adipogenesis

  6. Hepcidin (show HAMP Antibodies), Smad6 and Smad7 (show SMAD7 Antibodies) mRNA expression is coordinated in a way that it correlates with the activity of the Bmp/Smad (show SMAD1 Antibodies) signaling pathway.

  7. Sema7A (show SEMA7A Antibodies) positively regulates the production of transforming growth factor (TGF)-beta1 (show TGFB1 Antibodies) and Smad6 to facilitate West Nile virus pathogenesis in mice.

  8. Results indicate that peptidyl-prolyl isomerase Pin1 (show PIN1 Antibodies) Associates with Smad3 (show SMAD3 Antibodies) and Smad6.

  9. Data show that Runx1 (show RUNX1 Antibodies), in conjunction with Fli1 (show FLI1 Antibodies), Gata2 (show GATA2 Antibodies), and Scl (show TAL1 Antibodies), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.

  10. JNK1 (show MAPK8 Antibodies) activation decreases binding of inhibitory Smad6 to the type I BMP receptor (show BMPR1A Antibodies).

SMAD6 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SMAD6

  • SMAD family member 6 (smad6) antibody
  • SMAD family member 6 (SMAD6) antibody
  • SMAD family member 6 (Smad6) antibody
  • SMAD family member 6a (smad6a) antibody
  • AOVD2 antibody
  • b2b390Clo antibody
  • HsT17432 antibody
  • Madh6 antibody
  • MADH7 antibody
  • smad6 antibody
  • Smad6-like antibody
  • wu:fb22g05 antibody
  • Xsmad6 antibody

Protein level used designations for SMAD6

SMAD, mothers against DPP homolog 6 , MAD homolog 6 , Mothers against decapentaplegic, drosophila, homolog of, 6 , SMAD 6 , hSMAD6 , mothers against DPP homolog 6 , mothers against decapentaplegic homolog 6 , Smad 6 , mad homolog 7 , MAD, mothers against decapentaplegic homolog 6

GENE ID SPECIES
100038072 Xenopus (Silurana) tropicalis
4091 Homo sapiens
17130 Mus musculus
367100 Rattus norvegicus
374096 Gallus gallus
487612 Canis lupus familiaris
511279 Bos taurus
116992 Danio rerio
Selected quality suppliers for anti-SMAD6 (SMAD6) Antibodies
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