anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) Antibodies

The protein encoded by SMARCA2 is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Additionally we are shipping SMARCA2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMARCA2 6595 P51531
SMARCA2 67155 Q6DIC0
SMARCA2 361745  
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Top anti-SMARCA2 Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-SMARCA2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Brm on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2.2). Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-Brm antibody. Immunofluorescence staining of a rabbit lung section. 50 μg Log in to see 6 to 8 Days
$154.07
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: SMARCA2 Sample Type: Jurkat Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rat Un-conjugated ChIP, ICC, IF, WB SMARCA2 / BRM antibody (mAb) tested by ChIP. Chromatin IP performed using the ChIP-IT® Express Kit (Catalog No. 53008) and HeLa Chromatin (1.5 x 106 cell equivalents per ChIP) using 10 µg of SMARCA2 / BRM antibody or the equivalent amount of rat IgG as a negative control. Real time, quantitative PCR (RT-qPCR) was performed on DNA purified from each of the ChIP reactions using a primer pair specific for the CD44 gene. Data are presented as Fold Enrichment of the ChIP antibody signal versus the negative control IgG using the ddCT method. SMARCA2 / BRM antibody (mAb) tested by Immunofluorescence. Formaldehyde fixed HeLa cells stained with SMARCA2 / BRM antibody at a 0.5 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
$495.83
Details
Chicken Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Brm on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2.2). Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-Brm antibody. Immunohistochemical staining of a rabbit lung section. 150 μg Log in to see 6 to 8 Days
$278.97
Details
Bat Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: BRM Antibody [NBP1-90015] - Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli & vesicles. Immunohistochemistry-Paraffin: BRM Antibody [NBP1-90015] - Staining of human cerebral cortex shows strong nuclear positivity in neuronal cells. 0.1 mL Log in to see 14 to 17 Days
$439.69
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$175.80
Details
Cow Rabbit Un-conjugated WB Western blot analysis of BRM expression in HepG2 (A), HeLa (B), THP1 (C), NIH3T3 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Dog Rabbit Un-conjugated IHC, ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details

SMARCA2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SMARCA2 Antibodies

  1. Chicken Monoclonal SMARCA2 Primary Antibody for IF, IP - ABIN967939 : Muchardt, Yaniv: A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. in The EMBO journal 1993 (PubMed)
    Show all 3 Pubmed References

  2. Chicken Monoclonal SMARCA2 Primary Antibody for IF, IP - ABIN967938 : Singh, Coe, Hong: A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. in Nature 1995 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal SMARCA2 Primary Antibody for ICC, IF - ABIN4285267 : Van Houdt, Nowakowska, Sousa, van Schaik, Seuntjens, Avonce, Sifrim, Abdul-Rahman, van den Boogaard, Bottani, Castori, Cormier-Daire, Deardorff, Filges, Fryer, Fryns, Gana, Garavelli et al.: Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome. ... in Nature genetics 2012 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal SMARCA2 Primary Antibody for ChIP, ICC - ABIN2668505 : Okada, Harada, Saiwai, Nakamura, Ohkawa: Generation of a rat monoclonal antibody specific for Brm. in Hybridoma (2005) 2009 (PubMed)

More Antibodies against SMARCA2 Interaction Partners

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) interaction partners

  1. This de novo SMARCA2 missense mutation c.3721C>G, p.Gln1241Glu is the only reported mutation on exon 26 outside the ATPase (show DNAH8 Antibodies) domain of SMARCA2 to be associated with Nicolaides-Baraitser syndrome and adds to chromatin remodeling as a pathway for epileptogenesis.

  2. We conclude that their features better resemble Coffin-Siris syndrome, rather than Nicolaides-Baraitser syndrome and that these features likely arise from SMARCA2 over-dosage. Pure 9p duplications (not caused by unbalanced translocations) are rare. Copy number analysis in patients with features that overlap with Coffin-Siris syndrome is recommended to further determine their genetic aspects.

  3. BRM could activate JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) pathway to promote pancreatic cancer growth and chemoresistance.

  4. BRM gene mutation, chromosome 9 monosomy or BRM deletion and CpG methylation contribute collectively to the loss of BRM expression in poorly differentiated clear cell renal cell carcinoma (show MOK Antibodies)

  5. BRM-741 and BRM-1321 insertion polymorphisms are associated with susceptibility to cancer.

  6. BRG1 (show SMARCA4 Antibodies)/BRM and c-MYC (show MYC Antibodies) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (show RAB1A Antibodies) in cancer.

  7. Two functional promoter BRM polymorphisms were not associated with pancreatic adenocarcinoma risk, but are strongly associated with survival.

  8. SMARCA4 (show SMARCA4 Antibodies) and SMARCA2 deficiency is observed in 5.1% and 4.8% of non-small cell lung cancer

  9. our data suggest that concomitant loss of SMARCA2 and SMARCA4 (show SMARCA4 Antibodies) is another hallmark of small cell carcinoma of the ovary, hypercalcemic type-a finding that offers new opportunities for therapeutic interventions.

  10. this study shows for the first time novel SMARCA4 (show SMARCA4 Antibodies)-deficient and SMARCA2-deficient variants in undifferentiated gastrointestinal tract carcinomas

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) interaction partners

  1. BRG1 (show SMARCA4 Antibodies)/BRM and c-MYC (show MYC Antibodies) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (show RAB1A Antibodies) in cancer.

  2. SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) chromatin remodeler subunits Brg1 (show SMARCA4 Antibodies) and Brm are expressed differentially during drug-induced liver injury and regeneration in a mouse model.

  3. these findings described a role for BRG1 (show SMARCA4 Antibodies) and BRM in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte

  4. BRM depletion enhances the proportion of cells expressing markers of osteoblast precursors at the expense of cells able to differentiate along the adipocyte lineage.

  5. Data show that knockdown of component of chromatin remodeling complex Brm or Baf170 (show SMARCC2 Antibodies) at different stages promotes reprogramming.

  6. Data reveal stage-specific roles of Brm during skeletal myogenesis, via formation of repressive and activatory SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complexes.

  7. Brm protects from UV-induced hyperplastic growth in both cutaneous and corneal keratinocytes

  8. Data suggest that Brg1 (show SMARCA4 Antibodies) and Brm integrate various proinflammatory cues into cell adhesion molecule (show MCAM Antibodies) transactivation in endothelial injury.

  9. A SMARCA2-containing residual SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex underlies the oncogenic activity of SMARCA4 (show SMARCA4 Antibodies) mutant cancers.

  10. study identifies NO and HDAC2 (show HDAC2 Antibodies) nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons

SMARCA2 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.

Gene names and symbols associated with SMARCA2

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (smarca2) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (Smarca2) antibody
  • 2610209L14Rik antibody
  • BAF190 antibody
  • Brahma antibody
  • brm antibody
  • hBRM antibody
  • hSNF2a antibody
  • NCBRS antibody
  • psa-4 antibody
  • SNF2 antibody
  • SNF2alpha antibody
  • Snf2l2 antibody
  • SNF2LA antibody
  • Sth1p antibody
  • SWI2 antibody
  • wu:fa56c07 antibody
  • wu:fi27f11 antibody
  • zgc:66238 antibody

Protein level used designations for SMARCA2

ATP-dependent helicase SMARCA2 , BAF190B , BRG1-associated factor 190B , SNF2-alpha , SNF2/SWI2-like protein 2 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2 , global transcription activator homologous sequence , probable global transcription activator SNF2L2 , protein brahma homolog , sucrose nonfermenting 2-like protein 2 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 , subunit of the SWI/SNF chromatin remodeling complex , phasmid Socket Absent PSA-4

GENE ID SPECIES
6595 Homo sapiens
403380 Xenopus laevis
396040 Gallus gallus
67155 Mus musculus
334032 Danio rerio
476335 Canis lupus familiaris
540904 Bos taurus
361745 Rattus norvegicus
100126853 Sus scrofa
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