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SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. Additionally we are shipping Single-Minded Homolog 2 (Drosophila) Proteins (2) and many more products for this protein.
Showing 10 out of 50 products:
Cow (Bovine) Polyclonal SIM2 Primary Antibody for WB - ABIN2780639
Laffin, Wellberg, Kwak, Burghardt, Metz, Gustafson, Schedin, Porter: Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2. in Molecular and cellular biology 2008
Show all 2 Pubmed References
Human Polyclonal SIM2 Primary Antibody for ELISA, WB - ABIN562879
Zhang, Xu, Cao, Wei, Yang, Uzan, Peng: Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way. in Cell stress & chaperones 2010
Mouse (Murine) Polyclonal SIM2 Primary Antibody for ELISA, WB - ABIN4353807
Fei, Wu, Zhou, Wang, Wang, Yin, Wang, Qiu: [Association study of SIM2 gene polymorphisms with susceptibility to congenital scoliosis in a Chinese Han population]. in Zhonghua yi xue za zhi 2010
Two genes, OR51E2 (show OR51E2 Antibodies) and SIM2, and two miRNAs, miR (show MLXIP Antibodies)-200c and miR (show MLXIP Antibodies)-200b, showed significant association with prostate cancer.
In SH-SY5Y cells, ethanol exposure increased Sim2 expression in a manner similar to that of cleaved caspase 3. PKA activation was required for this. Sim2 might be involved in activating caspase 3 and ethanol-induced apoptosis in SH-SY5Y cells.
a single peptide containing multiple SIM2 epitopes can be used to induce both a CD4 (show CD4 Antibodies) and CD8 (show CD8A Antibodies) T cell response, providing a peptide-based vaccine formulation for potential use in immunotherapy of various cancers.
Data showed that SIM2 was highly expressed in human glioma tumors and cell lines and its short form might increase the invasion of glioma cells through the alteration of epithelial-mesenchymal transition.
Data suggest selected SIM1 (show SIM1 Antibodies) variants exhibit poor dimerization with ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2 (show ARNT2 Antibodies)) and anomalous intracellular localization; data were used to predict spot in SIM1 (show SIM1 Antibodies)/SIM2 (residues 290-326) critical in function.
miR (show MLXIP Antibodies)-200a is downregulated in human glioma and inhibition of miR (show MLXIP Antibodies)-200a caused upregulation of SIM2-s in T98G cells and promoted their motility.
Altered expression of SIM2 and ETS2 (show ETS2 Antibodies) could be one of the reasons for variable occurrence of different malignant conditions in Down syndrome.
These results suggest an involvement of SIM2 in key traits of prostate tumor cell biology.
Significantly lower frequency of SIM2 C-G haplotype (rs2073601-rs2073416) was noticed in individuals with Down syndrome (P value =0.01669) and their fathers (P value=0.01185)
Genetic variants of SIM2 gene may not be associated with the susceptibility to congenital scoliosis and different clinical phenotypes of CS in Chinese Han population.
Ethanol induced Sim2 expression in cerebral cortices of P7 Mice via the PKA pathway.
Study provides evidence that SIM2 binds a specific set of enhancer elements thus explaining how SIM2 can regulate its gene network in neuronal features.
Our results establish that SIM2 is a crucial regulator in controlling expression of intestinal AMPs (show ADSL Antibodies)
Sim2 prevents entry into the myogenic program by repressing MyoD (show MYOD1 Antibodies) transcription during limb embryonic myogenesis.
mammary gland involution is disrupted in Sim2s overexpression and STAT3 (show STAT3 Antibodies)-mediated signaling and other pathways involved in the acute phase response are inhibited
Differential activities of murine single minded 1 (SIM1 (show SIM1 Antibodies)) and SIM2 on a hypoxic response element
Sim2 mutants also develop congenital scoliosis, reflected by the unequal sizes of the left and right vertebrae and ribs. The spatial expression patterns of Sim2 in these skeletal elements suggest that Sim2 regulates their growth and/or integrity.
Data show that premature accumulation of hyaluronan in Sim2 -/- animal palates suggests a regulatory role for Sim2 in hyaluronan synthesis and in the establishment of craniofacial architecture.
Sim1 (show SIM1 Antibodies) and Sim2 act along compensatory, but not hierarchical, pathways, suggesting that they play similar roles in vivo.
Sim2 and Sim2s are isoforms that may play different roles during development or in tissue-specific effects on other protein-mediated pathways
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes
single-minded homolog 2
, class E basic helix-loop-helix protein 15
, single-minded homolog 2, short isoform
, transcription factor SIM2
, single-minded (Drosophila) homolog 2
, SIM transcription factor
, single-minded 2