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The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Additionally we are shipping TRPM2 Proteins (6) and many more products for this protein.
Showing 10 out of 80 products:
Mouse (Murine) Polyclonal TRPM2 Primary Antibody for ICC, IHC (fro) - ABIN259658
Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. in Neurotoxicology 2010
Show all 8 references for ABIN259658
Human Polyclonal TRPM2 Primary Antibody for ICC, IHC (fro) - ABIN153042
Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. in Journal of immunology (Baltimore, Md. : 1950) 2007
Show all 4 references for ABIN153042
Human Polyclonal TRPM2 Primary Antibody for ICC, IF - ABIN153041
Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. in Journal of medicinal chemistry 2013
Show all 2 references for ABIN153041
Mouse (Murine) Polyclonal TRPM2 Primary Antibody for ICC, IF - ABIN4362934
Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. in Scientific reports 2015
Cow (Bovine) Polyclonal TRPM2 Primary Antibody for IHC, WB - ABIN2781840
Hecquet, Ahmmed, Vogel, Malik: Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability. in Circulation research 2008
Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .
heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (show TRPC3 Antibodies) or TRPC7 protein induce enhanced receptor-activated Ca(2 (show CA2 Antibodies)+) influx that may lead to dysregulated cell growth in ADPKD
Study demonstrate that PRL (show PRL Antibodies) is necessary for the survival of (retinal pigment epithelium) RPE (show RPE Antibodies) under normal and advancing age conditions and, identified SIRT2 (show SIRT2 Antibodies) and TRPM2 (show CLU Antibodies) as molecular targets for the antioxidant and antiapoptotic actions of PRL (show PRL Antibodies) in the RPE (show RPE Antibodies).
TRPM2 (show CLU Antibodies) has a role in the DNA damage response of T cell leukemia cells in a BCL-2 (show BCL2 Antibodies) dependent manner
Data show that HEK293 cells expressing low levels of receptor potential melastatin 2 (TRPM2) chan (show TRPM3 Antibodies)nel wer (show CLU Antibodies)e more susceptible to silica nanoparticles (NPs) than those expressing high levels of TRPM2.
This is expected to provide a basis for inhibiting TRPM2 (show CLU Antibodies) for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.
In a transgenic mouse model of Alzheimer's disease, TRPM2 (show CLU Antibodies) was involved in neuronal toxicity and memory impairment.
These findings shed new light on the evolution of TRPM2 (show CLU Antibodies) and establish nvTRPM2 as a promising tool to decipher its complex gating mechanisms.
we report here a novel effect promoted by TRPM2 (show CLU Antibodies), where it functions to minimize DNA damage and thus may have a role in the protection of genomic DNA in breast cancer cells.
The HDACi-elicited upregulation of TRPM2 (show CLU Antibodies) expression.
TRPM2 (show CLU Antibodies) actively regulates the phosphorylation of GSK-3 (show GSK3b Antibodies) in the brain.
The degradation of zonula occludens-1 (ZO-1 (show TJP1 Antibodies)), and claudin-2 (show CLDN2 Antibodies) exhibited a great dependence on the activation of the transient receptor potential melastatin (show TRPM1 Antibodies) (TRPM) 2 (show CLU Antibodies) channel, phospholipase Cgamma1 (PLCgamma1 (show PLCG1 Antibodies)) and the protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies) (PKCalpha (show PKCa Antibodies)) signaling cascade.
Data show that macrophages from young mice showed lower transient receptor potential melastatin 2 (show TRPM3 Antibodies) (TRPM2) expression than those from senescent mice and had lower viability after silica nanoparticles (NPs (show NPS Antibodies)) exposure than those from senescent ones.
TRPM2 activation is likely to be mediated by ADP-ribose production via PARP (show PARP1 Antibodies) pathway
mice in which TRPM2 had been genetically deleted showed a striking deficit in their sensation of non-noxious warm temperatures, consistent with the idea that TRPM2 initiates a 'warm' signal which drives cool-seeking behaviour
findings provide compelling evidence that F. tularensis catalase (show CAT Antibodies) restricts reactive oxygen species to temper macrophage TRPM2-mediated Ca(2 (show CA2 Antibodies)+) signaling and limit host immune function.
TRPM2 plays roles in a wide range of pathological pain models based on peripheral and central neuroinflammation, rather than physiological nociceptive pain.
The findings provide evidence for a mechanism by which Abeta (show APP Antibodies) impairs neurovascular regulation and suggest that TRPM2 channels are a potential therapeutic target to counteract cerebrovascular dysfunction in Alzheimer's dementia.
Neointimal hyperplasia was substantially reduced in Trpm2 knockout mice.
endogenous redox signals in pancreatic beta cells elevate insulin (show INS Antibodies) secretion via TRPM2 sensitization and activity at body temperature
These results provide the first evidence to show a critical role for TRPM2 channel activation during reperfusion in the delayed increase in the [Zn(2+)]c and CA1 (show CA1 Antibodies) pyramidal neuronal death.
Postischemic neovascularization in mice required reactive oxygen species generation in endothelial cells and resultant TRPM2 activation.
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
transient receptor potential cation channel, subfamily M, member 2
, transient receptor potential cation channel, subfamily C, member 7
, transient receptor potential cation channel, subfamily C, member 7-like
, short transient receptor potential channel 7-like
, transient receptor potential cation channel subfamily M member 2-like
, transient receptor potential channel subfamily C member 7
, estrogen-responsive element-associated gene 1 protein
, long transient receptor potential channel 2
, transient receptor potential cation channel subfamily M member 2
, transient receptor potential channel 7
, transient receptor protein 7
, transient receptor potential melastatin family 2