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VTCN1 encodes a protein belonging to the B7 costimulatory protein family. Additionally we are shipping VTCN1 Antibodies (206) and VTCN1 Kits (14) and many more products for this protein.
Showing 10 out of 40 products:
Human VTCN1 Protein expressed in HEK-293 Cells - ABIN2180624
Salceda, Tang, Kmet, Munteanu, Ghosh, Macina, Liu, Pilkington, Papkoff: The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. in Experimental cell research 2005
Show all 4 references for 2180624
Mouse (Murine) VTCN1 Protein expressed in Human Cells - ABIN2007154
Suh, Wang, Duncan, Miyazaki, Cates, Walker, Gajewska, Deenick, Dawicki, Okada, Wakeham, Itie, Watts, Ohashi, Jordana, Yoshida, Mak: Generation and characterization of B7-H4/B7S1/B7x-deficient mice. in Molecular and cellular biology 2006
Results highlight an importance of VTCN1 stabilization on cell surfaces for the restora (show APCS Proteins)tion of altered balance of immune control during T1D.
Ablation of B7-H3 (show CD276 Proteins) but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.
that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease
B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells (
The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses.
Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 (show CD8A Proteins) T cell-induced diabetes.
B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction.
Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells.
Tissue-specific expression of B7x protects from CD4 (show CD4 Proteins) T cell-mediated autoimmunity.
While PD-L1 (show CD274 Proteins) expression correlated with MSI (show MSI1 Proteins) and high grade endometrial tumors, B7-H4 expression was independent of grade, histology and immune cell infiltration.
the present review highlights the therapeutic potential of targeting B7-H4 in cancer
Survival rate of the patients with higher B7-H4 expression was significantly worse than that of the patients with lower B7-H4 expression.
Study provides evidence that B7-H4 expression is present in cervical intraepithelial neoplasia and cervical cancer patients and suggests its involvement in cervical cancer progression.
this review shows that targeting the B7-H4 molecule may provide a promising potential for anticancer immunotherapy
Higher expression of HBx and B7-H4 was correlated with tumor progression of hepatitis B virus-hepatocellular carcinoma, suggesting that B7-H4 may be involved in facilitating HBV-related hepatocarcinogenesis.
Aberrant expression of B7-H4 has been identified to correlate with the TNM (show ODZ1 Proteins) stage, differentiation degree and lymph node metastasis in patients with HCC (show FAM126A Proteins).
B7-H4 may be overexpressed on the majority of cells in the IDC (show LMNA Proteins) microenvironment, including macrophages. In vitro experiments revealed that M1 and M2 cells expressed B7-H4. Compared with M1 cells, M2 cells exhibited significantly higher expression levels of B7-H4.
wortmannin and rapamycin inhibit B7-H4-mediated tumor immunoresistance through regulating B7-H4 subcellular distribution. Taken together, these results suggest that PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) inhibitors might be used for adjuvant therapy aimed at inhibition of immune evasion.
Unstable cell surface antigens are not suitable as targets for ADCC, and we therefore performed an indirect ADCC-redirecting T-cell cytotoxicity assay to study B7-H4 using polyclonal anti-mouse IgG antibody-mediated linking.
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
V-set domain-containing T-cell activation inhibitor 1
, V-set domain containing T cell activation inhibitor 1
, V-set domain containing T-cell activation inhibitor 1
, immune costimulatory protein B7-H4
, t cell costimulatory molecule B7x
, B7 family member, H4
, B7 superfamily member 1
, T cell costimulatory molecule B7x
, T-cell costimulatory molecule B7x