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anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Antibodies

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Additionally we are shipping PIKFYVE Kits (14) and PIKFYVE Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PIKFYVE 200576 Q9Y2I7
PIKFYVE 18711 Q9Z1T6
PIKFYVE 316457  
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Top anti-PIKFYVE Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of PIP5K3 (arrow) using rabbit polyclonal PIP5K3 Antibody 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain, using PIP5K (Phospho-Ser307) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using PIP5K (Phospho-Ser307) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of PIP5K3 (arrow) using rabbit polyclonal PIP5K3 Antibody (Center) (ABIN391254). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PIP5K3 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, IHC (p), RNAi, ELISA, WB Immunoperoxidase of monoclonal antibody to PIP5K3 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to PIP5K3 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PIP5K (Ab-307) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HepG2 cells, using PIP5K Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of COS7 cells, using PIP5K Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to PIP5K3 on HeLa cell (antibody concentration 10 µg/mL). Western blot analysis of PIP5K3 over-expressed 293 cell line, cotransfected with PIP5K3 Validated Chimera RNAi used as specificity and loading control. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 6 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details

PIKFYVE Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PIKFYVE Antibodies

  1. Human Polyclonal PIKFYVE Primary Antibody for EIA, IHC (p) - ABIN359341 : Sbrissa, Ikonomov, Strakova, Dondapati, Mlak, Deeb, Silver, Shisheva: A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. in Molecular and cellular biology 2004 (PubMed)
    Show all 4 references for ABIN359341

  2. Human Monoclonal PIKFYVE Primary Antibody for IF, IHC (p) - ABIN566937 : Tsuruta, Green, Rousset, Dolmetsch: PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death. in The Journal of cell biology 2009 (PubMed)
    Show all 2 references for ABIN566937

  3. Human Polyclonal PIKFYVE Primary Antibody for IHC (p), WB - ABIN391254 : Alesutan, Ureche, Laufer, Klaus, Zürn, Lindner, Strutz-Seebohm, Tavaré, Boehmer, Palmada, Lang, Seebohm, Lang: Regulation of the glutamate transporter EAAT4 by PIKfyve. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010 (PubMed)

  4. Human Polyclonal PIKFYVE Primary Antibody for IF, IHC - ABIN1531726 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)

More Antibodies against PIKFYVE Interaction Partners

Zebrafish phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) interaction partners

  1. Cloning of pip5k3 and report on its molecular characterization and expression pattern in adult fish as well as during development.

Human phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) interaction partners

  1. A novel heterozygous frameshift mutation (c.3151dupA) and a copy number variations in PIKFYVE gene have been found in two unrelated Fleck corneal dystrophy patients.

  2. The PIKfyve complex is required for APP (show APP Antibodies) trafficking, suggesting a feedback loop in which APP (show APP Antibodies), by binding to and stimulating phosphatidylinositol-3,5-bisphosphate vesicle formation may control its own trafficking.

  3. APP (show APP Antibodies) functionally cooperates with PIKfyve in vivo. This regulation is required for maintaining endosomal and neuronal function.

  4. data identify a novel role of the ArPIKfyve (show VAC14 Antibodies)-Sac3 (show MCM3AP Antibodies) complex in the mechanisms controlling aggregate formation of Sph1 (show ANK1 Antibodies) and suggest that Sac3 (show MCM3AP Antibodies) protein deficiency or overproduction may facilitate aggregation of aggregation-prone proteins

  5. Data suggest PIKFYVE, MTMR3 (myotubularin related protein 3 (show MTMR3 Antibodies)) and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein (show ARF3 Antibodies)); this process regulates migration/invasion of carcinoma/sarcoma.

  6. Data indicate that pharmacological or genetic inactivation of PIKfyve rapidly induces expression of the transcription repressor ATF3 (show ATF3 Antibodies), which is necessary and sufficient for suppression of type I IFN expression.

  7. Data indicate that AKT (show AKT1 Antibodies) promotes EGFR (show EGFR Antibodies) recycling by phosphorylating and activating PIKfyve.

  8. the present observations show that PKB (show AKT1 Antibodies) in conjunction with PIKfyve activates Kir2.1 (show KCNJ2 Antibodies) channels.

  9. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 (show MTMR3 Antibodies) regulates cell migration.

  10. PIP5Kalpha promotes TLR4 (show TLR4 Antibodies)-associated microglial inflammation by mediating PIP(2)-dependent recruitment of TIRAP (show TIRAP Antibodies) to the plasma membrane

Mouse (Murine) phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) interaction partners

  1. adipose tissue Pikfyve plays a key role in the mechanisms regulating glucose homeostasis and the PIKfyve pathway is critical in mammary epithelial differentiation during pregnancy and lactogenesis downstream of prolactin receptor (show PRLR Antibodies) signaling.

  2. AP-3 (show AP3B1 Antibodies) recruitment to TLR9 (show TLR9 Antibodies) endosomes was impaired by PIKfyve inhibition.

  3. PIKfyve mediates vesicle motility through the regulation of vesicle integrity in neurons.

  4. Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.

  5. Vps34 (show PIK3C3 Antibodies) is a main phosphatidylinositol 3-phosphate source for constitutive PIKfyve functionality.

  6. Daam2-PIP5K function, application of which stimulates remyelination after white matter injury

  7. Data indicate that pharmacological or genetic inactivation of PIKfyve rapidly induces expression of the transcription repressor ATF3 (show ATF3 Antibodies), which is necessary and sufficient for suppression of type I IFN expression.

  8. PIP5Kbeta negatively regulates axon elongation and growth cone size and is involved in the cellular signaling pathway for Sema3A-triggered repulsion in DRG neurons.

  9. PIKfyve is essential for systemic glucose homeostasis and insulin (show INS Antibodies)-regulated glucose uptake/GLUT4 (show SLC2A4 Antibodies) translocation in skeletal muscle.

  10. PIP5Kalpha promotes TLR4 (show TLR4 Antibodies)-associated microglial inflammation by mediating PIP(2)-dependent recruitment of TIRAP (show TIRAP Antibodies) to the plasma membrane

PIKFYVE Antigen Profile

Protein Summary

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve\; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD)\; an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PIKFYVE

  • phosphoinositide kinase, FYVE finger containing (pikfyve) antibody
  • phosphoinositide kinase, FYVE finger containing (PIKFYVE) antibody
  • phosphoinositide kinase, FYVE finger containing (Pikfyve) antibody
  • 5230400C17Rik antibody
  • CFD antibody
  • FAB1 antibody
  • fab1-like antibody
  • p235 antibody
  • Pip5k antibody
  • Pip5k3 antibody
  • Pipk5k3 antibody
  • PipkIII antibody
  • wu:fo93c03 antibody
  • ZFYVE29 antibody

Protein level used designations for PIKFYVE

1-phosphatidylinositol-3-phosphate 5-kinase , phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III , 1-phosphatidylinositol 3-phosphate 5-kinase , PIPkin-III , phosphatidylinositol 3-phosphate 5-kinase type III , type III PIP kinase , zinc finger, FYVE domain containing 29 , FYVE finger-containing phosphoinositide kinase , PtdIns(4)P-5-kinase , phosphatidylinositol-3-phosphate 5-kinase type III , phosphatidylinositol-4-phosphate 5-kinase, type III

GENE ID SPECIES
337690 Danio rerio
424114 Gallus gallus
459908 Pan troglodytes
478890 Canis lupus familiaris
790873 Bos taurus
200576 Homo sapiens
18711 Mus musculus
316457 Rattus norvegicus
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