STAT1 antibody (Signal Transducer and Activator of Transcription 1, 91kDa) (Tyr701)

Details for Product anti-STAT1 Antibody No. ABIN197172, Supplier: Log in to see
Antigen
  • IMUP
  • H2RSP
  • IMUP-1
  • IMUP-2
  • 2010005J02Rik
  • AA408197
  • DD6G4-4
  • CANDF7
  • ISGF-3
  • STAT91
  • STAT4
  • XStat1
  • STAT
  • STAT1
  • dZ182H3.3
  • si:by134g18.2
  • si:by51f19.1
  • si:dz182h3.3
  • si:dz199m19.1
  • si:dz73o4.2
  • signal transducer and activator of transcription 1, 91kDa
  • RIKEN cDNA 2200002D01 gene
  • signal transducer and activator of transcription 1
  • signal transducer and activator of transcription 4
  • STAT1
  • 2200002D01Rik
  • Stat1
  • stat1
  • stat4
Alternatives
anti-Mouse (Murine) STAT1 antibody for BioImaging
Epitope
Tyr701
99
78
58
27
23
21
19
16
15
15
15
13
9
6
5
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
605
296
241
43
27
26
26
23
18
15
14
11
9
5
4
4
3
3
2
2
2
1
1
Host
Rabbit
384
208
20
15
3
3
1
Clonality
Polyclonal
Conjugate
This STAT1 antibody is un-conjugated
18
17
15
14
14
14
7
7
6
6
6
6
5
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
2
2
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
528
178
162
111
99
54
52
29
21
14
10
5
5
4
2
1
1
1
Options
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human STAT1 around the phosphorylation site of tyrosine 701(T-G-YP-I-K).
Specificity STAT1 antibody detects endogenous levels of total STAT1 protein.
Purification Affinity-chromatography using epitope-specific immunogen
Alternative Name STAT1 (STAT1 Antibody Abstract)
Background Synonyms: Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84
Gene ID 9606
UniProt P42224
Research Area Cancer, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
Application Notes Western Blot: 1: 500approx. 1: 1000. Immunohistochemistry: 1: 50approx. 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS(without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-STAT1 antibody (Signal Transducer and Activator of Transcription 1, 91kDa) (Tyr701) (ABIN197172) anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (Tyr701) antibody
 image for anti-STAT1 antibody (Signal Transducer and Activator of Transcription 1, 91kDa) (Tyr701) (ABIN197172) anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (Tyr701) antibody (Image 2)
Background publications Heim: "The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus." in: Journal of receptor and signal transduction research, Vol. 19, Issue 1-4, pp. 75-120, 1999 (PubMed).

Demoulin, Van Roost, Stevens, Groner, Renauld: "Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9." in: The Journal of biological chemistry, Vol. 274, Issue 36, pp. 25855-61, 1999 (PubMed).

Durbin, Hackenmiller, Simon, Levy: "Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease." in: Cell, Vol. 84, Issue 3, pp. 443-50, 1996 (PubMed).

Meraz, White, Sheehan, Bach, Rodig, Dighe, Kaplan, Riley, Greenlund, Campbell, Carver-Moore, DuBois, Clark, Aguet, Schreiber: "Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway." in: Cell, Vol. 84, Issue 3, pp. 431-42, 1996 (PubMed).

Wakao, Gouilleux, Groner: "Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response." in: The EMBO journal, Vol. 13, Issue 9, pp. 2182-91, 1994 (PubMed).

Ihle, Witthuhn, Quelle, Yamamoto, Thierfelder, Kreider, Silvennoinen: "Signaling by the cytokine receptor superfamily: JAKs and STATs." in: Trends in biochemical sciences, Vol. 19, Issue 5, pp. 222-7, 1994 (PubMed).