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Details for Product No. ABIN197173

Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (Tyr701) antibody

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Antigen
Synonyms CANDF7, ISGF-3, STAT91, AA408197, 2010005J02Rik, DD6G4-4, XStat1, STAT4, IMUP, H2RSP, IMUP-1, IMUP-2
Epitope
»Alternatives Tyr701
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 6 references available
Catalog no. ABIN197173
Quantity 50 µg
Price
242.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human STAT1 around the phosphorylation site of tyrosine 701(T-G-YP-I-K).
Specificity STAT1 antibody detects endogenous levels of total STAT1 protein.
Purification Affinity-chromatography using epitope-specific immunogen
Alternative Name STAT1
Background Alternate names: Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84
NCBI Accession 9606
UniProt P42224
Research Area Cancer, Transcription Factors, Signaling, Receptors, Inflammation
Application Notes Western Blot: 1: 500~1: 1000. Immunohistochemistry: 1: 50~1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS(without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% sodium azide and 50% glycerol
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Background publications Wakao, Gouilleux, Groner: "Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response." in: The EMBO journal, Vol. 13, Issue 9, pp. 2182-91, 1994 (PubMed).

Ihle, Witthuhn, Quelle et al.: "Signaling by the cytokine receptor superfamily: JAKs and STATs." in: Trends in biochemical sciences, Vol. 19, Issue 5, pp. 222-7, 1994 (PubMed).

Meraz, White, Sheehan et al.: "Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway." in: Cell, Vol. 84, Issue 3, pp. 431-42, 1996 (PubMed).

Durbin, Hackenmiller, Simon et al.: "Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease." in: Cell, Vol. 84, Issue 3, pp. 443-50, 1996 (PubMed).

Heim: "The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus." in: Journal of receptor and signal transduction research, Vol. 19, Issue 1-4, pp. 75-120, 1999 (PubMed).

Demoulin, Van Roost, Stevens et al.: "Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9." in: The Journal of biological chemistry, Vol. 274, Issue 36, pp. 25855-61, 1999 (PubMed).

Alternatives for antigen "Signal Transducer and Activator of Transcription 1, 91kDa (STAT1)", type "Antibodies"
Hosts (228), (65), (5), (5), (2)
Reactivities (284), (157), (141), (44), (41), (30), (27), (3), (2), (1)
Applications (262), (88), (77), (76), (68), (30), (26), (16), (6), (6), (4), (3), (3), (1), (1), (1)
Conjugates (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Epitopes (51), (47), (37), (8), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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