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STAT3 antibody (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)) (AA 725-729)

Details for Product anti-STAT3 Antibody No. ABIN362567, Supplier: Log in to see
Antigen
Alternatives
anti-Human STAT3 antibody for Western Blotting
Epitope
AA 725-729
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84
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21
17
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8
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2
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2
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1
1
1
1
1
1
1
1
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1
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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249
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12
11
10
5
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2
1
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Host
Rabbit
455
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34
4
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1
Clonality
Polyclonal
Conjugate
This STAT3 antibody is un-conjugated
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11
7
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Application
Immunohistochemistry (IHC), Western Blotting (WB)
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25
24
13
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9
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3
3
2
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1
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Supplier
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Immunogen Peptide sequence around AA 725-729 (P-M-S-P-R) derived from Human STAT3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total STAT3 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name STAT3 (STAT3 Antibody Abstract)
Background Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.
Molecular Weight 88 kDa
NCBI Accession NP_003141
UniProt P40763
Research Area Embryogenesis, Embryonic stem cells, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Product cited in: Cheng, Wang, Xia et al.: "A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation." in: EMBO molecular medicine, Vol. 4, Issue 10, pp. 1112-25, 2012 (PubMed).

Yu, Qin, He et al.: "Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling." in: Hepatology (Baltimore, Md.), Vol. 54, Issue 3, pp. 979-88, 2011 (PubMed).

Background publications Bromberg, Wrzeszczynska, Devgan et al.: "Stat3 as an oncogene." in: Cell, Vol. 98, Issue 3, pp. 295-303, 1999 (PubMed).

Heim: "The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus." in: Journal of receptor and signal transduction research, Vol. 19, Issue 1-4, pp. 75-120, 1999 (PubMed).

Catlett-Falcone, Landowski, Oshiro et al.: "Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells." in: Immunity, Vol. 10, Issue 1, pp. 105-15, 1999 (PubMed).

Garcia, Jove: "Activation of STAT transcription factors in oncogenic tyrosine kinase signaling." in: Journal of biomedical science, Vol. 5, Issue 2, pp. 79-85, 1998 (PubMed).

Takeda, Noguchi, Shi et al.: "Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 8, pp. 3801-4, 1997 (PubMed).