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E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial))

Details for Product anti-CDH1 Antibody No. ABIN614765, Supplier: Log in to see
Antigen
  • AA960649
  • arc-1
  • Arc-1
  • Arc1
  • b-cadherin
  • cadherin-1
  • CD324
  • cd324
  • cdh1
  • cdh1-a
  • cdhc-A
  • cdhe
  • CDHE
  • cdhp
  • E-Cad
  • E-cad
  • E-cadherin
  • ecad
  • Ecad
  • ECAD
  • hjmd
  • L-CAM
  • l-cam
  • lcam
  • LCAM
  • pcad
  • si:dz180o5.2
  • Um
  • uvo
  • UVO
  • uvomorulin
  • xb-cad
  • XB-cadherin
  • XBcad
  • xcdh1
  • XTCAD-1
Reactivity
Human
642
172
97
29
16
12
6
6
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Host
Mouse
394
264
28
21
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This E-cadherin antibody is un-conjugated
38
31
31
17
17
15
14
12
11
10
10
9
8
8
8
8
8
7
7
7
7
5
4
3
3
3
3
3
2
2
2
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
497
257
194
170
134
133
103
99
65
35
12
12
7
6
6
4
2
2
2
2
2
2
1
1
1
1
Supplier
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Immunogen T-47D cells
Clone 67A4
Isotype IgG1
Specificity This antibody recognizes CD324 / E-cadherin, an approximately 100 kDa epithelial cell adhesion molecule, whose detection is important for determination of invasive potential of epithelial neoplasms.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein-A affinity chromatography
Purity > 95 % pure by SDS-PAGE
Alternative Name CD324 / Cadherin-1 (CDH1 Antibody Abstract)
Background CD324 / E-cadherin is an epithelial cell surface molecule, which provides calcium-dependent homophilic interactions with E-cadherin of another cell. These intaractions take part in morphogenetic programs controlling the maintenance of the structural and functional integrity of epithelia and affect invasive potential of epithelial neoplasms. CD324 / E-cadherin is implicated in cell growth and differentiation, cell recognition, and sorting during developmental morphogenesis, as well as in aggregation-dependent cell survival. CD324 / E-cadherin-mediated cell adhesion system is highly regulated from inside the cell by a number of intracellular signaling pathways.Synonyms: CAM 120/80, CDH1, CDHE, E-cadherin, Epithelial cadherin, UVO, Uvomorulin
Gene ID 999, 9606
UniProt P12830
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Product cited in: Lin, Liao, Lee, Hung, Sayion, Chen, Kang, Huang, Cherng: "Molecular events associated with epithelial to mesenchymal transition of nasopharyngeal carcinoma cells in the absence of Epstein-Barr virus genome." in: Journal of biomedical science, Vol. 16, pp. 105, 2009 (PubMed).

Furio, Guezennec, Ducarre, Guesnet, Peguet-Navarro: "Differential effects of allergens and irritants on early differentiating monocyte-derived dendritic cells." in: European journal of dermatology : EJD, Vol. 18, Issue 2, pp. 141-7, 2008 (PubMed).

Caberg, Hubert, Begon, Herfs, Roncarati, Boniver, Delvenne: "Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes." in: Carcinogenesis, Vol. 29, Issue 7, pp. 1441-7, 2008 (PubMed).

Background publications Robertson, Ali, McDonnell, Burt, Kirby: "Chronic renal allograft dysfunction: the role of T cell-mediated tubular epithelial to mesenchymal cell transition." in: Journal of the American Society of Nephrology : JASN, Vol. 15, Issue 2, pp. 390-7, 2004 (PubMed).

Novak, Kraft, Haberstok, Geiger, Allam, Bieber: "A reducing microenvironment leads to the generation of FcepsilonRIhigh inflammatory dendritic epidermal cells (IDEC)." in: The Journal of investigative dermatology, Vol. 119, Issue 4, pp. 842-9, 2002 (PubMed).

Kutlesa, Wessels, Speiser, Steiert, Müller, Klein: "E-cadherin-mediated interactions of thymic epithelial cells with CD103+ thymocytes lead to enhanced thymocyte cell proliferation." in: Journal of cell science, Vol. 115, Issue Pt 23, pp. 4505-15, 2002 (PubMed).

Pece, Gutkind: "Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41227-33, 2001 (PubMed).

Servet-Delprat, Vidalain, Bausinger, Manié, Le Deist, Azocar, Hanau, Fischer, Rabourdin-Combe: "Measles virus induces abnormal differentiation of CD40 ligand-activated human dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1753-60, 2000 (PubMed).

Pece, Chiariello, Murga, Gutkind et al.: "Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion ..." in: The Journal of biological chemistry, Vol. 274, Issue 27, pp. 19347-51, 1999 (PubMed).

Bühring, Müller, Herbst, Cole, Rappold, Schuller, Zhu, Fritzsch, Faul, Armeanu, Ullrich, Klein, Schmidt: "The adhesion molecule E-cadherin and a surface antigen recognized by the antibody 9C4 are selectively expressed on erythroid cells of defined maturational stages." in: Leukemia, Vol. 10, Issue 1, pp. 106-16, 1996 (PubMed).

Armeanu, Bühring, Reuss-Borst, Müller, Klein: "E-cadherin is functionally involved in the maturation of the erythroid lineage." in: The Journal of cell biology, Vol. 131, Issue 1, pp. 243-9, 1995 (PubMed).

Takeichi: "Cadherin cell adhesion receptors as a morphogenetic regulator." in: Science (New York, N.Y.), Vol. 251, Issue 5000, pp. 1451-5, 1991 (PubMed).