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MDM2 antibody
MDM2
Reactivity: Human
IHC (p), IP, IHC (fro), IHC (rs)
Host: Mouse
Monoclonal
unconjugated
Product Details anti-MDM2 Antibody
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Target
See all MDM2 Antibodies
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Reactivity
All reactivities for MDM2 antibodies
Human
Host
All hosts for MDM2 antibodies
Mouse
Clonality
All clonalities for MDM2 antibodies
Monoclonal
Conjugate
All conjugates for MDM2 antibodies
This MDM2 antibody is un-conjugated
Application
All applications for MDM2 antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Resin Sections) (IHC (rs))
Purpose
Mouse Anti-Human MDM2
Specificity
DS-MB-01877 recognizes the 90kD MDM2 protein, which forms a complex with p53 leading to p53 inhibition. DS-MB-01877 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI. It is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer. reacts with: Mouse. Antibody reactivity and working conditions may vary between species.
Characteristics
Transcription and its regulation
Purification
Purified
Immunogen
Synthetic peptide, CSRPSTSSRRRAISE, corresponding to amino acids 154-167 of human MDM2.
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Immunohistology - Frozen, Immunoprecipitation, Immunohistology - Paraffin, Immunohistology - Resin
Restrictions
For Research Use only
Handling
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Concentration
IgG concentration 1.0 mg/ml
Buffer
Phosphate buffered saline pH7.4
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
-20°C
Target Details for MDM2
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Target
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Alternative Name
MDM2 (MDM2 Products )
Synonyms
ACTFS antibody, HDMX antibody, hdm2 antibody, zgc:109834 antibody, 1700007J15Rik antibody, AA415488 antibody, Mdm-2 antibody, MDM2 proto-oncogene antibody, MDM2 proto-oncogene S homeolog antibody, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) antibody, MDM2 oncogene, E3 ubiquitin protein ligase antibody, transformed mouse 3T3 cell double minute 2 antibody, MDM2 antibody, mdm2.S antibody, Mdm2 antibody, mdm2 antibody
Pathways
p53 Signaling , PI3K-Akt Signaling , Cell Division Cycle , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Autophagy , Ubiquitin Proteasome Pathway
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