Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody

Details for Product No. ABIN965839
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Antigen
Synonyms
E-Cad, E-cadherin, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, xb-cad, xcdh1, Arc1, AA960649, E-cad, Ecad, L-CAM, UVO, Um, Arc- ... show more
E-Cad, E-cadherin, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, xb-cad, xcdh1, Arc1, AA960649, E-cad, Ecad, L-CAM, UVO, Um, Arc-1, CD324, CDHE, ECAD, LCAM, arc-1, cd324, cdhe, ecad, cdh1, si:dz180o5.2 show less
Reactivity
Human, Mouse (Murine), Monkey
(325), (105), (80), (34), (32), (22), (19), (18), (18), (15), (6), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(225), (141), (9), (5), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(18), (16), (9), (7), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA
(253), (111), (107), (70), (62), (58), (55), (51), (31), (30), (8), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.1 mL
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Catalog No. ABIN965839
440.00 $
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Immunogen Purified recombinant fragment of human CDH1 expressed in E. Coli.
Clone 7A2
Isotype IgG1
Purification Ascitic fluid
Alternative Name CDH1
Background E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calciumdependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.
Tissue specificity: Non-neural epithelial tissues.
Synonyms: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1
Molecular Weight 135kDa
Gene ID 999
Research Area Proteolysis / Ubiquitin
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Rigby: "Statistical reviewing for disability and rehabilitation." in: Disability and rehabilitation, Vol. 31, Issue 7, pp. 515-21, 2009 (PubMed).

Barrett, Lee, Lees et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, 2009 (PubMed).

Schietke, Warnecke, Wacker et al.: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, 2010 (PubMed).

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