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Details for Product No. ABIN965839

Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody

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Antigen
Synonyms
UVO, CDHE, ECAD, LCAM, Arc-1, CD324, arc-1, cd324, cdhe, ecad, lcam, uvo, AA960649, E-cad, Ecad, L-CAM, Um, E-cadherin, E-Cad, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp ... show more
Reactivity
»Alternatives Human, Mouse (Murine), Monkey
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA
Pubmed 3 references available
Catalog no. ABIN965839
Quantity 0.1 mL
Price
426.25 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 5 to 7 Business Days
Immunogen Purified recombinant fragment of human CDH1 expressed in E. Coli.
Clone 7A2
Isotype IgG1
Purification Ascitic fluid
Alternative Name CDH1
Background E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calciumdependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.
Tissue specificity: Non-neural epithelial tissues.
Synonyms: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1
Molecular Weight 135kDa
Gene ID 999
Research Area Proteolysis / Ubiquitin
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Preservative Sodium azide
Storage 4 °C
Product cited in: Rigby: "Statistical reviewing for disability and rehabilitation." in: Disability and rehabilitation, Vol. 31, Issue 7, pp. 515-21, 2009 (PubMed).

Barrett, Lee, Lees et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, 2009 (PubMed).

Schietke, Warnecke, Wacker et al.: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, 2010 (PubMed).

Alternatives for antigen "Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1)", type "Antibodies"
Hosts (136), (131), (9), (5), (4)
Reactivities (252), (94), (67), (34), (34), (24), (20), (19), (15), (13), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applications (181), (80), (63), (61), (42), (36), (34), (31), (31), (31), (12), (8), (6), (3), (2), (1), (1), (1)
Conjugates (11), (8), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1)
Epitopes (14), (14), (12), (10), (8), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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