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E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial))

Details for Product anti-CDH1 Antibody No. ABIN965839, Supplier: Log in to see
Antigen
  • E-Cad
  • E-cadherin
  • XB-cadherin
  • XBcad
  • XTCAD-1
  • b-cadherin
  • cadherin-1
  • cdh1-a
  • cdhc-A
  • cdhp
  • hjmd
  • l-cam
  • lcam
  • pcad
  • uvo
  • uvomorulin
  • xb-cad
  • xcdh1
  • Arc1
  • AA960649
  • E-cad
  • Ecad
  • L-CAM
  • UVO
  • Um
  • Arc-1
  • CD324
  • CDHE
  • ECAD
  • LCAM
  • arc-1
  • cd324
  • cdhe
  • ecad
  • cdh1
  • si:dz180o5.2
Reactivity
Human, Mouse (Murine), Monkey
428
130
95
21
20
11
6
4
4
3
2
1
1
1
1
1
1
1
1
1
1
1
Host
Mouse
254
193
18
17
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This E-cadherin antibody is un-conjugated
29
24
18
13
10
7
6
5
4
4
3
3
3
3
3
3
2
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
309
142
99
94
93
58
48
43
36
32
13
9
6
4
2
2
2
2
2
1
1
1
1
1
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of human CDH1 expressed in E. Coli.
Clone 7A2
Isotype IgG1
Purification Ascitic fluid
Alternative Name CDH1 (CDH1 Antibody Abstract)
Background E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calciumdependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.
Tissue specificity: Non-neural epithelial tissues.
Synonyms: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1
Molecular Weight 135kDa
Gene ID 999
Research Area Proteolysis / Ubiquitin
Pathways
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Schietke, Warnecke, Wacker et al.: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, 2010 (PubMed).

Barrett, Lee, Lees et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. ..." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, 2009 (PubMed).

Rigby: "Statistical reviewing for disability and rehabilitation." in: Disability and rehabilitation, Vol. 31, Issue 7, pp. 515-21, 2009 (PubMed).