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Details for Product No. ABIN969036

Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody

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Antigen
Synonyms
UVO, CDHE, ECAD, LCAM, Arc-1, CD324, arc-1, cd324, cdhe, ecad, lcam, uvo, AA960649, E-cad, Ecad, L-CAM, Um, E-cadherin, E-Cad, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp ... show more
Reactivity
»Alternatives Human, Mouse (Murine), Monkey
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)
Pubmed 3 references available
Catalog no. ABIN969036
Quantity 100 µL
Price
363.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human CDH1 expressed in E. coli.
Clone 7H12
Isotype IgG1
Purification Ascites
Alternative Name CDH1
Background Synonyms:
UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1
E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression. Tissue specificity: Non-neural epithelial tissues.
Molecular Weight 135 kDa
Gene ID 999
Research Area Proteolysis / Ubiquitin
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Barrett, Lee, Lees et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, 2009 (PubMed).

Wang, Yao, Zhang et al.: "[Expression and significance of CD147 and E-cadherin in human gastric carcinoma]." in: Zhonghua zhong liu za zhi [Chinese journal of oncology], Vol. 31, Issue 7, pp. 515-9, 2009 (PubMed).

Schietke, Warnecke, Wacker et al.: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, 2010 (PubMed).

Alternatives for antigen "Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1)", type "Antibodies"
Hosts (131), (122), (9), (5), (4)
Reactivities (238), (82), (55), (34), (34), (24), (20), (19), (15), (13), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
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Epitopes (11), (9), (8), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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