anti-E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial))

Details for Product anti-CDH1 Antibody No. ABIN969036
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Antigen
Synonyms
E-Cad, E-cadherin, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, xb-cad, xcdh1, Arc1, AA960649, E-cad, Ecad, L-CAM, UVO, Um, Arc- ... show more
E-Cad, E-cadherin, XB-cadherin, XBcad, XTCAD-1, b-cadherin, cadherin-1, cdh1-a, cdhc-A, cdhp, hjmd, l-cam, lcam, pcad, uvo, uvomorulin, xb-cad, xcdh1, Arc1, AA960649, E-cad, Ecad, L-CAM, UVO, Um, Arc-1, CD324, CDHE, ECAD, LCAM, arc-1, cd324, cdhe, ecad, cdh1, si:dz180o5.2 show less
Reactivity
Human, Mouse (Murine), Monkey
(425), (120), (87), (22), (13), (10), (8), (6), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(266), (181), (28), (16), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
This E-cadherin antibody is un-conjugated
(27), (26), (17), (13), (10), (8), (7), (6), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1)
Application
ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
(314), (146), (111), (104), (95), (63), (57), (50), (40), (30), (10), (8), (6), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 100 μL
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Immunogen Purified recombinant fragment of human CDH1 expressed in E. coli.
Clone 7H12
Isotype IgG1
Purification Ascites
Alternative Name CDH1 (CDH1 Antibody Abstract)
Background E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Molecular Weight 135 kDa
Gene ID 999
HGNC 999
Research Area Proteolysis / Ubiquitin
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody Figure 3: Flow cytometric analysis of Hela cells using CDH1 mouse mAb (green) and neg...
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody (2) Figure 2: Immunohistochemical analysis of paraffin-embedded gastric cancer tissues (l...
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody (3) Figure 1: Western blot analysis using CDH1 mouse mAb against LNCAP (1) ,A431 (2), DU1...
Product cited in: Schietke, Warnecke, Wacker et al.: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, 2010 (PubMed).

Wang, Yao, Zhang et al.: "[Expression and significance of CD147 and E-cadherin in human gastric carcinoma]." in: Zhonghua zhong liu za zhi [Chinese journal of oncology], Vol. 31, Issue 7, pp. 515-9, 2009 (PubMed).

Barrett, Lee, Lees et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. ..." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, 2009 (PubMed).

Validation Images
Catalog No. ABIN969036
393.80 $
Plus shipping costs $45.00
Quantity
Price
100 μL
393.80 $

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