anti-Human Caspase 4 antibody for Enzyme Immunoassay

Recommended Caspase 4 Antibody (supplied by: Log in to see )

Antigen
Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies
  • CASP4
  • ICE(rel)II
  • ICEREL-II
  • ICH-2
  • Mih1/TX
  • TX
  • Casp11
  • Caspl
  • ich-3
  • CASP1
  • CASP13
  • caspase 4
  • caspase 11
  • caspase 4, apoptosis-related cysteine peptidase
  • caspase-4-like
  • CASP4
  • LOC100101589
  • Casp4
  • LOC100359184
Epitope
N-Term
39
22
14
10
6
6
5
5
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
187
108
48
19
3
1
1
Host
Rabbit
192
30
22
16
7
Clonality
Polyclonal
Conjugate
This Caspase 4 antibody is un-conjugated
15
13
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
242
110
74
60
33
27
23
19
13
9
8
6
3
1
1
1
Supplier
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Catalog No. ABIN5554659
$ 375.38
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN5554660 EIA IHC (p) WB Rabbit IgG Intermediate Domain Log in to see Polyclonal

General

Antigen Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies
Epitope N-Term
(39), (22), (14), (10), (6), (6), (5), (5), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(187), (108), (48), (19), (3), (1), (1)
Host Rabbit
(192), (30), (22), (16), (7)
Clonality
Polyclonal
Conjugate This Caspase 4 antibody is un-conjugated
(15), (13), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(242), (110), (74), (60), (33), (27), (23), (19), (13), (9), (8), (6), (3), (1), (1), (1)
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Product Details anti-Caspase 4 Antibody

Target Details Caspase 4 Application Details Handling Images
Specificity This antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-4.
Purification Affinity chromatography purified via peptide column
Immunogen Human Casp-4 / ICH-2 / ICE rel II / Mih1 (N-Terminus) Peptide
Isotype IgG

Target Details Caspase 4

Product Details anti-Caspase 4 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Caspase-4 (CASP4 Antibody Abstract)
Background Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease (5).Synonyms: CASP4, ICE(rel)-II, ICH2, Protease ICH-2, Protease TX
Gene ID 837
UniProt P49662
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Handling Images back to top
Application Notes ELISA. Western Blot: Casp-4 antibody can be used for the detection of Caspase-4 at 1 μg/mL. Depending on cell lines or tissues used, other cleavage products may be observed. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Images back to top
Concentration 1.0 mg/mL
Buffer PBS, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.