|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies|
|Conjugate||This TNFRSF12A antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-TNFRSF12A AntibodyTarget Details TNFRSF12A Application Details Handling Images
|Specificity||This antibody reacts to Fn14.|
|Purification||Affinity chromatography purified via peptide column|
|Immunogen||Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.|
Target Details TNFRSF12AProduct Details anti-TNFRSF12A Antibody Application Details Handling Images back to top
|Alternative Name||CD266 / TweakR (TNFRSF12A Antibody Abstract)|
|Background||TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.Synonyms: FGF-inducible 14, FN14, Fibroblast growth factor-inducible immediate-early response protein 14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, Tweak receptor|
|Pathways||Apoptosis, Regulation of Cell Size|
Application DetailsProduct Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Handling Images back to top
ELISA. Western BLot: 2-4 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|