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anti-Human TNFRSF12A antibody for Functional Studies

Recommended TNFRSF12A Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
  • AI255180
  • C87282
  • CD266
  • Fn14
  • FN14
  • HPIP
  • TWEAK-R
  • TweakR
  • TWEAKR
Reactivity
Human
95
44
23
Host
Mouse
49
47
2
Clonality
Monoclonal
Conjugate
This TNFRSF12A antibody is un-conjugated
11
6
5
2
2
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (IHC)
52
47
18
17
15
13
11
11
3
3
2
1
1
1
1
Supplier
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Catalog No. ABIN2664460
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.000873873 ABIN2749025 Func IHC (f) FACS WB Mouse IgG2b Log in to see ITEM-4 3
0.000873873 ABIN2749054 Func IHC (f) FACS WB Mouse IgG2b Log in to see ITEM-4 3
0.000873873 ABIN2749122 Func IHC (f) FACS WB PE Mouse IgG2b Log in to see ITEM-4 3
0.000873873 ABIN281765 Func FACS IHC (fro) Mouse IgG1 kappa Log in to see ITEM-1
0.000873873 ABIN3199692 FACS Func IHC (fro) WB PE Mouse IgG2b Log in to see ITEM-4
0.000873873 ABIN2678252 Func IHC (fro) FACS WB Mouse IgG2b kappa Log in to see ITEM-4
0.000873873 ABIN3199690 FACS Func IHC (fro) WB Mouse IgG2b Log in to see ITEM-4
0.000873873 ABIN3199691 FACS Func IHC (fro) WB Mouse IgG2b Log in to see ITEM-4
0.000873873 ABIN3037011 Func FACS IHC WB Mouse IgG2b Log in to see
0.000873873 ABIN3037013 Func FACS IHC WB PE Mouse IgG2b Log in to see
0.000873873 ABIN2142027 Func ELISA Mouse IgG2b kappa Log in to see ITEM-4
0.000873873 ABIN2142029 Func ELISA Mouse IgG1 kappa Log in to see ITEM-1
0.000873873 ABIN3037012 Func FACS IHC WB Mouse IgG2b Log in to see

Top referenced anti-TNFRSF12A antibody for Functional Studies

Similar anti-TNFRSF12A Antibodies

Application / Reactivity Human
Blocking Reagent (BR) 1 Antibodies
ELISA 16 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Flow Cytometry (FACS) 46 Antibodies
Functional Studies (Func) 14 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 18 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 3 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 3 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 11 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 15 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Neutralization (Neut) 1 Antibodies
Western Blotting (WB) 50 Antibodies

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
Reactivity Human
(95), (44), (23)
Host Mouse
(49), (47), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF12A antibody is un-conjugated
(11), (6), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (IHC)
(52), (47), (18), (17), (15), (13), (11), (11), (3), (3), (2), (1), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-TNFRSF12A Antibody

Target Details TNFRSF12A Application Details Handling References for anti-TNFRSF12A Antibody (ABIN2664460) Images
Purification The antibody was purified by affinity chromatography.
Clone ITEM-1
Isotype IgG1 kappa

Target Details TNFRSF12A

Product Details anti-TNFRSF12A Antibody Application Details Handling References for anti-TNFRSF12A Antibody (ABIN2664460) Images back to top
Antigen
Alternative Name CD266 (TNFRSF12A Antibody Abstract)
Background TWEAK receptor is also known as fibroblast growth factor inducible 14 kD protein (Fn14) or CD266. It is a 14 kD transmembrane protein that is expressed on a variety of tissue types. This receptor binds TWEAK and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The TWEAK receptor is rapidly induced during liver regeneration and m play a role in hepatocyte growth. TWEAK receptor engagement can induce cell death and may play a role in inflammation. The ITEM-1 antibody is useful for flow cytometric analysis, induction of tumor cells apoptosis or necrotic cell death, enhancing endothelial cell proliferation, and immunohistochemistry on frozen tissues.
Pathways Apoptosis

Application Details

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Handling References for anti-TNFRSF12A Antibody (ABIN2664460) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details References for anti-TNFRSF12A Antibody (ABIN2664460) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-TNFRSF12A Antibody (ABIN2664460)

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling Images back to top
Background publications

Muñoz-García, Martín-Ventura, Martínez, Sánchez, Hernández, Ortega, Ortiz, Egido, Blanco-Colio: "Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin." in: Stroke; a journal of cerebral circulation, Vol. 37, Issue 8, pp. 2044-53, 2006

Felli, Pedini, Zeuner, Petrucci, Testa, Conticello, Biffoni, Di Cataldo, Winkles, Peschle, De Maria: "Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of erythropoiesis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 3, pp. 1464-72, 2005

Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, 2002

Feng, Guo, Factor, Thorgeirsson, Bell, Testa, Peifley, Winkles: "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas." in: The American journal of pathology, Vol. 156, Issue 4, pp. 1253-61, 2000

Meighan-Mantha, Hsu, Guo, Brown, Feng, Peifley, Alberts, Copeland, Gilbert, Jenkins, Richards, Winkles: "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration." in: The Journal of biological chemistry, Vol. 274, Issue 46, pp. 33166-76, 2000

Lynch, Wang, Lund, Chen, Leal, Wiley: "TWEAK induces angiogenesis and proliferation of endothelial cells." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8455-9, 1999

Images

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling References for anti-TNFRSF12A Antibody (ABIN2664460) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-TNFRSF12A antibody (Tumor Necrosis Factor Receptor Superfamily, Member 12A) (ABIN2664460) anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) antibody