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anti-Human TNFRSF12A antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended TNFRSF12A Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
  • AI255180
  • C87282
  • CD266
  • Fn14
  • FN14
  • HPIP
  • TWEAK-R
  • TweakR
  • TWEAKR
Reactivity
Human
95
44
23
Host
Rabbit
50
46
2
Clonality
Polyclonal
Conjugate
This TNFRSF12A antibody is un-conjugated
11
6
5
2
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
51
48
19
17
14
14
11
11
3
3
2
1
1
1
Supplier
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Catalog No. ABIN499851
$ 401.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.34288716 ABIN569611 IHC (p) Rabbit IgG AA 55-63, Internal Region Log in to see Polyclonal
0.0008982679 ABIN1688736 IHC (p) Rabbit IgG C-Term Log in to see SP134
0.0008982679 ABIN303304 IHC (p) WB Rabbit Log in to see Polyclonal
0.0008982679 ABIN1687984 IHC (p) Rabbit IgG Internal Region Log in to see Polyclonal
0.0008982679 ABIN1688720 FACS IHC (p) WB Rabbit IgG C-Term Log in to see SP134
0.0008982679 ABIN1687033 IHC (p) Rabbit IgG Internal Region Log in to see Polyclonal
0.0008982679 ABIN1740476 IHC (p) WB Rabbit IgG Log in to see Polyclonal
0.0008982679 ABIN741062 IHC (p) Biotin Rabbit IgG AA 101-129 Log in to see Polyclonal
0.0008982679 ABIN741069 IHC (p) HRP Rabbit IgG AA 101-129 Log in to see Polyclonal
0.0008982679 ABIN214532 IHC (p) WB Rabbit Log in to see Polyclonal
0.0008982679 ABIN1942897 FACS IHC (p) WB Rabbit IgG C-Term Log in to see SP134
0.0008982679 ABIN741060 IF (p) IHC (p) Rabbit IgG AA 101-129 Log in to see Polyclonal
0.0008982679 ABIN1942898 IHC (p) Rabbit IgG Internal Region Log in to see Polyclonal
0.0008982679 ABIN2766874 IHC (p) WB Rabbit Log in to see Polyclonal

Top referenced anti-TNFRSF12A antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-TNFRSF12A Antibodies

Application / Reactivity Human
Blocking Reagent (BR) 1 Antibodies
ELISA 16 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Flow Cytometry (FACS) 46 Antibodies
Functional Studies (Func) 14 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 18 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 3 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 3 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 11 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 15 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Neutralization (Neut) 1 Antibodies
Western Blotting (WB) 50 Antibodies

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
Reactivity Human
(95), (44), (23)
Host Rabbit
(50), (46), (2)
Clonality
Polyclonal
Conjugate This TNFRSF12A antibody is un-conjugated
(11), (6), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(51), (48), (19), (17), (14), (14), (11), (11), (3), (3), (2), (1), (1), (1)
Pubmed 4 references available
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Product Details anti-TNFRSF12A Antibody

Target Details TNFRSF12A Application Details Handling References for anti-TNFRSF12A Antibody (ABIN499851) Images
Specificity This antibody reacts to Fn14.
Purification Affinity chromatography purified via peptide column
Immunogen Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.
Isotype IgG

Target Details TNFRSF12A

Product Details anti-TNFRSF12A Antibody Application Details Handling References for anti-TNFRSF12A Antibody (ABIN499851) Images back to top
Antigen
Alternative Name CD266 / TweakR (TNFRSF12A Antibody Abstract)
Background TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.Synonyms: FGF-inducible 14, FN14, Fibroblast growth factor-inducible immediate-early response protein 14, TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A, Tweak receptor
Gene ID 51330
NCBI Accession NP_057723
UniProt Q9NP84
Research Area Receptors
Pathways Apoptosis

Application Details

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Handling References for anti-TNFRSF12A Antibody (ABIN499851) Images back to top
Application Notes ELISA. Western BLot: 2-4 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details References for anti-TNFRSF12A Antibody (ABIN499851) Images back to top
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.

References for anti-TNFRSF12A Antibody (ABIN499851)

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling Images back to top
Background publications

Brown, Richards, Hanscom, Feng, Winkles: "The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation." in: The Biochemical journal, Vol. 371, Issue Pt 2, pp. 395-403, 2003

Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, 2002

Feng, Guo, Factor, Thorgeirsson, Bell, Testa, Peifley, Winkles: "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas." in: The American journal of pathology, Vol. 156, Issue 4, pp. 1253-61, 2000

Chicheportiche, Bourdon, Xu, Hsu, Scott, Hession, Garcia, Browning: "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32401-10, 1998

Images

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling References for anti-TNFRSF12A Antibody (ABIN499851) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TNFRSF12A antibody (Tumor Necrosis Factor Receptor Superfamily, Member 12A) (ABIN499851) Immunohistochemistry of Fn14 in human liver tissue with Fn14 antibody at 2.5 μg/ml.
Western Blotting (WB) image for anti-TNFRSF12A antibody (Tumor Necrosis Factor Receptor Superfamily, Member 12A) (ABIN499851) Western blot analysis of Fn14 in HepG2 cells with AP30344PU-N Fn14 antibody at (A) 2 ...