anti-Mouse (Murine) TNFRSF12A antibody for Flow Cytometry

Recommended TNFRSF12A Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
  • CD266
  • FN14
  • TWEAKR
  • AI255180
  • C87282
  • Fn14
  • HPIP
  • TWEAK-R
  • TweakR
  • tumor necrosis factor receptor superfamily, member 12A
  • tumor necrosis factor receptor superfamily, member 12a
  • TNFRSF12A
  • Tnfrsf12a
Reactivity
Human, Mouse (Murine)
93
58
30
3
3
2
2
2
2
1
1
1
Host
Mouse
51
41
8
3
Clonality
Monoclonal
Conjugate
This TNFRSF12A antibody is conjugated to Biotin
11
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS)
54
48
20
17
16
14
13
12
3
2
2
1
1
1
1
1
1
1
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Catalog No. ABIN2661016
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
14.324151 ABIN2663248 FACS PE Mouse IgG2b kappa Log in to see ITEM-4 7
14.324151 ABIN2664461 FACS Mouse IgG2b kappa Log in to see ITEM-4 8
1 ABIN4900099 CyTOF ELISA (Capture) FACS IHC WB Goat IgG AA 28-79 Log in to see Polyclonal
1 ABIN2479564 IHC (fro) FACS WB Mouse IgG2b Log in to see ITEM-4 1
1 ABIN2479570 FACS FITC Mouse IgG2b Log in to see ITEM-4 1
1 ABIN2479572 FACS PE Mouse IgG2b Log in to see ITEM-4 1
1 ABIN2749025 Func IHC (f) FACS WB Mouse IgG2b Log in to see ITEM-4 3
1 ABIN4900098 CyTOF FACS WB Rat IgG2a AA 28-79 Log in to see 314636
1 ABIN1819127 FACS IHC (fro) WB PE Mouse IgG2b Log in to see ITEM-4
1 ABIN2749122 Func IHC (f) FACS WB PE Mouse IgG2b Log in to see ITEM-4 3
1 ABIN2749054 Func IHC (f) FACS WB Mouse IgG2b Log in to see ITEM-4 3
1 ABIN1820056 FACS IHC (fro) WB FITC Mouse IgG2b Log in to see ITEM-4
1 ABIN3199690 FACS Func IHC (fro) WB Mouse IgG2b Log in to see ITEM-4
1 ABIN956715 FACS IHC ELISA WB Goat IgG Extracellular Domain Log in to see Polyclonal
1 ABIN3199692 FACS Func IHC (fro) WB PE Mouse IgG2b Log in to see ITEM-4
1 ABIN3199691 FACS Func IHC (fro) WB Mouse IgG2b Log in to see ITEM-4
1 ABIN1820057 IHC (fro) FACS WB Mouse IgG2b Log in to see ITEM-4
1 ABIN602498 IHC (fro) FACS WB Mouse IgG2b Log in to see
1 ABIN5540154 FACS Func IHC (fro) WB Mouse IgG2b Log in to see ITEM-4
1 ABIN5540153 FACS Func IHC (fro) WB Mouse IgG2b Log in to see ITEM-4

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
Reactivity Human, Mouse (Murine)
(93), (58), (30), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Host Mouse
(51), (41), (8), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF12A antibody is conjugated to Biotin
(11), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS)
(54), (48), (20), (17), (16), (14), (13), (12), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 7 references available
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Product Details anti-TNFRSF12A Antibody

Target Details TNFRSF12A Application Details Handling References for anti-TNFRSF12A antibody (ABIN2661016) Images
Purification The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Clone ITEM-4
Isotype IgG2b kappa

Target Details TNFRSF12A

Product Details anti-TNFRSF12A Antibody Application Details Handling References for anti-TNFRSF12A antibody (ABIN2661016) Images back to top
Antigen
Alternative Name CD266 (TNFRSF12A Antibody Abstract)
Background CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia.
Pathways Apoptosis, Regulation of Cell Size

Application Details

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Handling References for anti-TNFRSF12A antibody (ABIN2661016) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details References for anti-TNFRSF12A antibody (ABIN2661016) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-TNFRSF12A antibody (ABIN2661016)

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling Images back to top
Background publications

Karaca, Swiderska-Syn, Xie, Syn, Krüger, Machado, Garman, Choi, Michelotti, Burkly, Ochoa, Diehl: "TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice." in: PLoS ONE, Vol. 9, Issue 1, pp. e83987, 2014

Muñoz-García, Martín-Ventura, Martínez, Sánchez, Hernández, Ortega, Ortiz, Egido, Blanco-Colio: "Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin." in: Stroke; a journal of cerebral circulation, Vol. 37, Issue 8, pp. 2044-53, 2006

Polek, Talpaz, Darnay, Spivak-Kroizman: "TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 32317-23, 2003

Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, 2002

Feng, Guo, Factor, Thorgeirsson, Bell, Testa, Peifley, Winkles: "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas." in: The American journal of pathology, Vol. 156, Issue 4, pp. 1253-61, 2000

Meighan-Mantha, Hsu, Guo, Brown, Feng, Peifley, Alberts, Copeland, Gilbert, Jenkins, Richards, Winkles: "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration." in: The Journal of biological chemistry, Vol. 274, Issue 46, pp. 33166-76, 2000

Lynch, Wang, Lund, Chen, Leal, Wiley: "TWEAK induces angiogenesis and proliferation of endothelial cells." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8455-9, 1999

Images

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling References for anti-TNFRSF12A antibody (ABIN2661016) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) antibody (Biotin) (ABIN2661016) anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) antibody (Biotin)