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Browse our Rap Guanine Nucleotide Exchange Factor (GEF) 3 Proteins (RAPGEF3)

Full name:
Rap Guanine Nucleotide Exchange Factor (GEF) 3 Proteins (RAPGEF3)
On www.antibodies-online.com are 8 Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Proteins from 5 different suppliers available. Additionally we are shipping Rap Guanine Nucleotide Exchange Factor (GEF) 3 Antibodies (64) and many more products for this protein. A total of 84 Rap Guanine Nucleotide Exchange Factor (GEF) 3 products are currently listed.
Synonyms:
2310016P22Rik, 9330170P05Rik, bcm910, CAMP-GEFI, Epac, Epac1, HSU79275, RAPGEF3, si:dkey-27m20.2
list all proteins Gene Name GeneID UniProt
RAPGEF3 10411 O95398
RAPGEF3 223864 Q8VCC8
RAPGEF3 59326 Q9Z1C8

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Rap Guanine Nucleotide Exchange Factor (GEF) 3 Proteins (RAPGEF3) by Origin

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More Proteins for Rap Guanine Nucleotide Exchange Factor (GEF) 3 Interaction Partners

Cow (Bovine) Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) interaction partners

  1. prostacyclin regulates bone growth via the Epac/Rap1 pathway

Xenopus laevis Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) interaction partners

  1. cAMP binds Xepac protein enabling it to activate the Ca2+ pathway, which is necessary to start and maintain X. laevis vitellogenin uptake.

Human Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) interaction partners

  1. during Epac1-induced activation of mTORC1 and mTORC2 (show CRTC2 Proteins), Epac1 may have an additional function as a scaffold protein (show HOMER1 Proteins)

  2. The overexpression of EPAC1 can be used as a marker to predict the outcome of patients with GC, and EPAC1 represents a potential therapeutic modality for treating gastric cancer

  3. our data provide new insight into the essential role of Epac1 in regulating growth of ovarian cancer cells and suggest that Epac1 might represent an attractive therapeutic target for treatment of ovarian cancer.

  4. These findings suggested Epac is connected to the SDF-1 (show CXCL12 Proteins) signaling cascades. In conclusion, our study revealed that Epac plays a role in human mesenchymal stem cells (hMSCs)homing by promoting adhesion and migration. Appropriate manipulation of Epac may enhance the homing of hMSCs and facilitate their future clinical applications.

  5. EPAC activity is increased in arterial endothelial cells exposed to laminar-fluid shear stress, activation of EPAC1, and its activation of Rap1, plays a role in promoting alignment and elongation of these cells in the direction of flow.

  6. EPAC activation consistently reverses clinical and experimental impairment of neutrophil phagocytosis. EPAC signals through Rap-1 (show RABGEF1 Proteins) and bypasses RhoA (show RHOA Proteins). EPAC activation represents a novel potential means by which to reverse impaired neutrophil phagocytosis.

  7. The cAMP exerted divergent effects on proliferation and promoted cell adhesion of different neuroendocrine cell types, these effects being mediated by both Epac and PKA and involving the same effector GTPase Rap1.

  8. Impaired microtubule dynamics, due to reduced EPAC1 signaling, links CFTR (show CFTR Proteins) function to cystic fibrosis (show S100A8 Proteins) cellular events.

  9. Identified a conserved nuclear pore localisation signal (NPLS; amino acids 764-838 of EPAC1) in the catalytic domains of the cAMP-sensors, EPAC1 and EPAC2A. EPAC1 and EPAC2 (show RAPGEF4 Proteins), display distinct subcellular distributions.

  10. Thyroid carcinoma cell lines showed no or very weak EPAC1 expression and exhibited no growth-promoting effect after EPAC stimulation.

Mouse (Murine) Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) interaction partners

  1. Epac1 is involved in AC5 (show ADCY5 Proteins)-mediated catecholamine stress-induced cardiac fibrosis. Epac1 is involved in AC5 (show ADCY5 Proteins)-mediated elongation of atrial fibrillation.

  2. Within heart mitochondria, different Epac1 microdomains control myocardial cell death.

  3. GRK2 inhibits Epac1-to-Rap1 signaling by phosphorylation of Epac1 at Ser-108 in the Disheveled/Egl-10/pleckstrin domain, inhibiting agonist-induced Epac1 translocation to the plasma membrane, reducing Rap1 activation.

  4. DPP4i restores cardiac remodeling and apoptosis caused by the pathological decline in circulating GLP-1 in response to pressure overload. EPAC1 is essential for cardiomyocyte survival via the cAMP/Rap1 activation independently of PKA.

  5. Epac2 (show RAPGEF4 Proteins), but not Epac1 has a role in decreasing severity of ischemic retinopathy after retinal ischemia/reperfusion injury

  6. Epac1 deficiency attenuates neointima formation through, at least in part, inhibition of SMC (show DYM Proteins) migration, in which a decrease in Ca(2 (show CA2 Proteins)+) influx and a suppression of cofilin (show CFL1 Proteins)-mediated lamellipodia formation occur.

  7. PDE4 (show PDE4A Proteins) inhibition reduces neointima formation and inhibits VCAM-1 (show VCAM1 Proteins) expression and histone methylation in an Epac-dependent manner.

  8. Epac1 deletion protected against beta-AR-induced cardiac remodelling and prevented the induction of autophagy.

  9. Epac1 induces beta2-AR-mediated masseter muscle hypertrophy without influencing slow-to-fast MHC isoform transition, probably via activation of Akt (show AKT1 Proteins) and its downstream molecules and increase of CaMKII (show CAMK2G Proteins)-mediated HDAC4 (show HDAC5 Proteins) phosphorylation.

  10. these data show that Treg degrade ATP to adenosine via CD39, attracting DC by activating Epac1-Rap1-dependent pathways.

Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Protein Profile

Protein Summary

binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner

Alternative names and synonyms associated with Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3)

  • Rap guanine nucleotide exchange factor (GEF) 3 (RAPGEF3)
  • Rap guanine nucleotide exchange factor (GEF) 3 (rapgef3)
  • Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3)
  • 2310016P22Rik protein
  • 9330170P05Rik protein
  • bcm910 protein
  • CAMP-GEFI protein
  • Epac protein
  • Epac1 protein
  • HSU79275 protein
  • RAPGEF3 protein
  • si:dkey-27m20.2 protein

Protein level used designations for RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3 , RAP guanine-nucleotide-exchange factor 3 , exchange protein directly activated by cAMP 1 , rap guanine nucleotide exchange factor 3 , Rap1 guanine-nucleotide exchange factor , rap guanine nucleotide exchange factor 3-like , 9330170P05Rik , EPAC 1 , Rap1 guanine-nucleotide-exchange factor directly activated by cAMP , cAMP-regulated guanine nucleotide exchange factor I , exchange factor directly activated by cAMP 1 , cAMP-GEFI , cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) , epac 1

GENE ID SPECIES
426888 Gallus gallus
467198 Pan troglodytes
486591 Canis lupus familiaris
535383 Bos taurus
703967 Macaca mulatta
733186 Xenopus laevis
100174087 Pongo abelii
100320646 Danio rerio
100399583 Callithrix jacchus
100473947 Ailuropoda melanoleuca
100560594 Anolis carolinensis
10411 Homo sapiens
223864 Mus musculus
59326 Rattus norvegicus
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