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prostacyclin regulates bone growth via the Epac/Rap1 pathway
cAMP binds Xepac protein enabling it to activate the Ca2+ pathway, which is necessary to start and maintain X. laevis vitellogenin uptake.
No significant association was observed between RAPGEF3 SNPs and the risk of Alzheimer's disease or neuropsychiatric inventory scores.
This review focus is on the function of Epac in the heart. Accumulating evidence has revealed that both Epac1 and Epac2 (show RAPGEF4 Proteins) play important roles in the structure and function of the heart under physiological and pathological conditions. [review]
This interaction is promoted by EPAC1 activation, triggering its translocation to the plasma membrane and binding to NHERF1 (show SLC9A3R1 Proteins). Our findings identify a new CFTR (show CFTR Proteins)-interacting protein and demonstrate that cAMP activates CFTR (show CFTR Proteins) through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1.
The contribution of EGFR (show EGFR Proteins), EPAC, and Ca(2 (show CA2 Proteins)+) in CDCA-induced activation of CFTR (show CFTR Proteins)-dependent Cl(-) secretion.
Microtubule stabilization was further suggested by the finding that ascorbate increased the amount of Epac1 bound to alpha-tubulin (show TUBA4A Proteins).
during Epac1-induced activation of mTORC1 and mTORC2 (show CRTC2 Proteins), Epac1 may have an additional function as a scaffold protein (show HOMER1 Proteins)
The overexpression of EPAC1 can be used as a marker to predict the outcome of patients with GC, and EPAC1 represents a potential therapeutic modality for treating gastric cancer
our data provide new insight into the essential role of Epac1 in regulating growth of ovarian cancer cells and suggest that Epac1 might represent an attractive therapeutic target for treatment of ovarian cancer.
These findings suggested Epac is connected to the SDF-1 (show CXCL12 Proteins) signaling cascades. In conclusion, our study revealed that Epac plays a role in human mesenchymal stem cells (hMSCs)homing by promoting adhesion and migration. Appropriate manipulation of Epac may enhance the homing of hMSCs and facilitate their future clinical applications.
EPAC activity is increased in arterial endothelial cells exposed to laminar-fluid shear stress, activation of EPAC1, and its activation of Rap1, plays a role in promoting alignment and elongation of these cells in the direction of flow.
Epac1 exerts a tonic inhibition of in vivo basal microvascular permeability
In behavioral tests, Epac1-/- mice exhibited similar phenotype to those of WT mice.
2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 (show CNR1 Proteins) receptors. Among the six isoforms of phospholipase C (PLC (show PLC Proteins); PLCbeta, PLCgamma, PLCdelta, PLCepsilon (show PLCE1 Proteins), PLCzeta (show PLCz1 Proteins), PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT (show DHDDS Proteins)-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress...
Data suggest that Epac1 reduces formation of the NLRP3 (show NLRP3 Proteins) inflammasome to reduce inflammatory responses in the retinal vasculature.
Results demonstrate that Epac1 plays an important role in regulating energy balance and glucose homeostasis by promoting leptin (show LEP Proteins) expression and secretion in white adipose tissue.
data demonstrate that endogenous PGE2, EP2 (show SPAG11A Proteins) receptors, and EPAC are prerequisites for maximal LPS (show TLR4 Proteins)-induced IL-33 (show IL33 Proteins) expression and that exogenous PGE2 can amplify IL-33 (show IL33 Proteins) production via EP2 (show SPAG11A Proteins) and EP4 (show PTGER4 Proteins) receptors.
Epac1 is involved in AC5 (show ADCY5 Proteins)-mediated catecholamine stress-induced cardiac fibrosis. Epac1 is involved in AC5 (show ADCY5 Proteins)-mediated elongation of atrial fibrillation.
Within heart mitochondria, different Epac1 microdomains control myocardial cell death.
GRK2 inhibits Epac1-to-Rap1 signaling by phosphorylation of Epac1 at Ser-108 in the Disheveled/Egl-10/pleckstrin domain, inhibiting agonist-induced Epac1 translocation to the plasma membrane, reducing Rap1 activation.
DPP4i restores cardiac remodeling and apoptosis caused by the pathological decline in circulating GLP-1 in response to pressure overload. EPAC1 is essential for cardiomyocyte survival via the cAMP/Rap1 activation independently of PKA.
binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner
Rap guanine nucleotide exchange factor (GEF) 3
, RAP guanine-nucleotide-exchange factor 3
, exchange protein directly activated by cAMP 1
, rap guanine nucleotide exchange factor 3
, Rap1 guanine-nucleotide exchange factor
, rap guanine nucleotide exchange factor 3-like
, EPAC 1
, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
, cAMP-regulated guanine nucleotide exchange factor I
, exchange factor directly activated by cAMP 1
, cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI)
, epac 1