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Browse our anti-JAK3 (JAK3) Antibodies

Full name:
anti-Tyrosine-Protein Kinase JAK3 Antibodies (JAK3)
On www.antibodies-online.com are 85 Tyrosine-Protein Kinase JAK3 (JAK3) Antibodies from 17 different suppliers available. Additionally we are shipping JAK3 Kits (20) and JAK3 Proteins (12) and many more products for this protein. A total of 123 JAK3 products are currently listed.
Synonyms:
fae, JAK, JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK, RATJAK3, wil
list all antibodies Gene Name GeneID UniProt
JAK3 3718 P52333
JAK3 16453 Q62137
JAK3 25326  

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Top referenced anti-JAK3 Antibodies

  1. Human Monoclonal JAK3 Primary Antibody for ELISA - ABIN393714 : Kameda, Shide, Shimoda, Hidaka, Kubuki, Katayose, Taniguchi, Sekine, Kamiunntenn, Maeda, Nagata, Matsunaga, Shimoda: Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma. in International journal of hematology 2010 (PubMed)
    Show all 5 references for ABIN393714

  2. Human Monoclonal JAK3 Primary Antibody for EIA, IF - ABIN1109428 : Suzuki, Aoyagi: Total synthesis of (-)-chamobtusin A. in Organic letters 2012 (PubMed)
    Show all 3 references for ABIN1109428

  3. Human Monoclonal JAK3 Primary Antibody for ICC, FACS - ABIN969224 : Lai, Jin, Graham, Witthuhn, Ihle, Liu: A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells. in The Journal of biological chemistry 1995 (PubMed)
    Show all 3 references for ABIN969224

  4. Human Monoclonal JAK3 Primary Antibody for IF, WB - ABIN2869455 : Kawamura, McVicar, Johnston, Blake, Chen, Lal, Lloyd, Kelvin, Staples, Ortaldo: Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 3 references for ABIN2869455

  5. Human Polyclonal JAK3 Primary Antibody for IF, IHC - ABIN1532701 : Grimwood, Gordon, Olsen, Terry, Schmutz, Lamerdin, Hellsten, Goodstein, Couronne, Tran-Gyamfi, Aerts, Altherr, Ashworth, Bajorek, Black, Branscomb, Caenepeel, Carrano, Caoile, Chan, Christensen et al.: The DNA sequence and biology of human chromosome 19. ... in Nature 2004 (PubMed)

  6. Chicken Polyclonal JAK3 Primary Antibody for WB - ABIN2785645 : Cheng, Ross, Frost, Kirken: Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity. in Molecular and cellular biology 2008 (PubMed)

  7. Human Polyclonal JAK3 Primary Antibody for WB - ABIN658182 : Yu, Sun, Feng, Tan, Fang, Zhao, Zhao, Pu, Huang, Xiang, Cao, He: MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 (PubMed)

More Antibodies against JAK3 Interaction Partners

Human Tyrosine-Protein Kinase JAK3 (JAK3) interaction partners

  1. Foxp3 (show FOXP3 Antibodies) has a rapid turn over in Treg partly controlled at the transcriptional level by the JAK/STAT (show STAT1 Antibodies) pathway

  2. Results confirm that JAK3 is mutated in T-PLL and underscore the potential therapeutical relevance of epigenetic regulator.

  3. Data provide the first evidence that de-regulated Jak3/STAT3 (show STAT3 Antibodies)/STAT5 (show STAT5A Antibodies) signalling in CTCL (show TSPYL2 Antibodies) cells represses the expression of the gene encoding miR (show MLXIP Antibodies)-22, a novel tumor suppressor miRNA.

  4. Study describes three patients with a novel deep intronic mis (show AMH Antibodies)-splicing mutation in JAK3 as a cause of T-B+NK- severe combined immunodeficiency (show PRKDC Antibodies).

  5. Jak3 has a role in promoting mucosal tolerance through suppressed expression and limiting activation of TLRs thereby preventing intestinal and systemic chronic low-grade inflammation and associated obesity and MetS

  6. that JAK3 may contribute to the pathogenesis of pediatric ALL and serve as an important therapeutic target which can be leveraged to improve outcomes for pediatric patients with ALL.

  7. These results do not confirm association between JAK3 polymorphisms and cardiovascular disease in rheumatoid arthritis.

  8. Activating Janus kinase 3 mutation is associated with mycosis fungoides.

  9. The study reports the first patient with relapsed pediatric Early T-cell precursor acute lymphoblastic leukemia to exhibit a homozygous JAK3 activating mutation, V674A, caused by acquired uniparental disomy.

  10. JAK inhibitor ruxolitinib (that inhibits mainly the JAK3/STAT5 (show STAT5A Antibodies) pathway) affects key characteristics of human NK cells, such as cytokine-induced expansion and killing via an impaired cytokine-mediated NK cell activation

Mouse (Murine) Tyrosine-Protein Kinase JAK3 (JAK3) interaction partners

  1. Foxp3 (show FOXP3 Antibodies) has a rapid turn over in Treg partly controlled at the transcriptional level by the JAK/STAT (show STAT1 Antibodies) pathway

  2. JAK3 contributes to the regulation of membrane Kv1.5 (show KCNA5 Antibodies) protein abundance and activity, an effect sensitive to ouabain and thus possibly involving Na(+)/K(+) ATPase (show ATP1A1 Antibodies) activity.

  3. JAK3 deficiency is followed by down-regulation of cytosolic Ca(2 (show CA2 Antibodies)+) release, receptor and store operated Ca(2 (show CA2 Antibodies)+) entry and Na(+)/Ca(2 (show CA2 Antibodies)+) exchanger activity in dendritic cells.

  4. Jak3 has a role in promoting mucosal tolerance through suppressed expression and limiting activation of TLRs thereby preventing intestinal and systemic chronic low-grade inflammation and associated obesity and MetS

  5. Our results demonstrate that JAK3/STAT6 (show STAT6 Antibodies) has an important role in bone marrow-derived fibroblast activation, extracellular matrix production, and interstitial fibrosis development.

  6. results showed that different JAK3 mutations induce constitutive activation through distinct mechanisms, pointing to specific therapeutic perspectives

  7. JAK3 down-regulates Na(+)/K(+)-ATPase (show ATP1A1 Antibodies) activity, an effect involving gene expression and profoundly curtailing ATP consumption.

  8. In conclusion, JAK3 deficiency leads to increased formation of calcitriol, which contributes to or even accounts for increased release of FGF23 (show FGF23 Antibodies) and enhanced intestinal phosphate absorption.

  9. JAK1 (show JAK1 Antibodies) and JAK3 mutants cooperate in T-cell transformation

  10. Jak3 pseudokinase mutants require JAK1 (show JAK1 Antibodies) for their transforming potential causing T-cell acute lymphoblastic leukemia in a mouse model.

Pig (Porcine) Tyrosine-Protein Kinase JAK3 (JAK3) interaction partners

  1. Data show that IL-4 (show IL4 Antibodies) induces upregulation of the junction protein claudin-5 (show CLDN5 Antibodies) in endothelial cells (ECs) through activation of Jak/STAT6 (show STAT6 Antibodies) and phosphorylation and translocation of FoxO1 (show FOXO1 Antibodies) from the nucleus to the cytoplasm.

JAK3 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

Alternative names and synonyms associated with JAK3

  • Janus kinase 3 (JAK3) antibody
  • Janus kinase 3 (Jak3) antibody
  • fae antibody
  • JAK antibody
  • JAK-3 antibody
  • JAK3_HUMAN antibody
  • JAKL antibody
  • L-JAK antibody
  • LJAK antibody
  • RATJAK3 antibody
  • wil antibody

Protein level used designations for JAK3

Janus kinase 3 (a protein tyrosine kinase, leukocyte) , leukocyte Janus kinase , tyrosine-protein kinase JAK3 , JAK-3 , Janus kinase 3 protein-tyrosine kinase , Janus kinase 3, protein-tyrosine kinase , Janus tyrosine kinase

GENE ID SPECIES
100147451 Equus caballus
3718 Homo sapiens
16453 Mus musculus
25326 Rattus norvegicus
395845 Gallus gallus
610004 Canis lupus familiaris
100518649 Sus scrofa
538276 Bos taurus
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