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|Antigen||Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This IRAK1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
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Product Details anti-IRAK1 AntibodyTarget Details IRAK1 Application Details Handling Images
|Specificity||IRAK antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IRAK.|
|Immunogen||Human IRAK (C-Terminus) Peptide|
Target Details IRAK1Product Details anti-IRAK1 Antibody Application Details Handling Images back to top
|Alternative Name||IRAK1 (IRAK1 Antibody Abstract)|
|Background||Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).Synonyms: IRAK, IRAK-1, Interleukin-1 receptor-associated kinase 1|
|Research Area||Cytokines, Inflammation, Receptors|
|Pathways||NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-IRAK1 Antibody Target Details IRAK1 Handling Images back to top
ELISA. Western Blot: 1/1000. Immunocytochemistry. Immunoprecipitation: 2 to 4 μg per sample. An 80 kDa band should be detected in the lysate from non-activated cells. It has no crossresponse to IRAK2.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IRAK1 Antibody Target Details IRAK1 Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|