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anti-Human MAP3K14 Antibodies:
anti-Rat (Rattus) MAP3K14 Antibodies:
anti-Mouse (Murine) MAP3K14 Antibodies:
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Human Polyclonal MAP3K14 Primary Antibody for WB - ABIN392539
Bouzakri, Zierath: MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. in The Journal of biological chemistry 2007
Show all 4 Pubmed References
results suggest that changes in the relative concentrations of RelB (show RELB Antibodies), NIK:IKK1, and p100 (show CUX1 Antibodies) during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100 (show CUX1 Antibodies).
report a detailed state-of-the-art mass spectrometry-based protein-protein interaction network including the noncanonical NF-kappaB (show NFKB1 Antibodies) signaling nodes TRAF2 (show TRAF2 Antibodies), TRAF3 (show TRAF3 Antibodies), IKKalpha (show CHUK Antibodies), NIK, and NF-kappaB2/p100 (show CUX1 Antibodies); also provide a differential interactome of NIK mutants that cause immunodeficiency
OLFM1 (show OLFM1 Antibodies) is a negative regulator of non-canonical NF-kappaB (show NFKB1 Antibodies) signalling by interacting with and inhibiting NIK. Thus, OLFM1 (show OLFM1 Antibodies) may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC (show CALR Antibodies)) patients.
The expression of OTUD7B (show OTUD7B Antibodies) and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM (show ODZ1 Antibodies) stage. high OTUD7B (show OTUD7B Antibodies)/low NIK index can predict an good prognosis.
NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.
This study identified two novel independent loci (MAP3K14 and CARD9 (show CARD9 Antibodies)) strongly associated with joint damage in Mexican Americans and European Americans and a few shared loci showing suggestive evidence for association.
The forced expression of NDRG2 (show NDRG2 Antibodies) in ATL cells down-regulates not only the canonical pathway by inhibiting AKT (show AKT1 Antibodies) signaling but also the non-canonical pathway by inducing NF-kappaB (show NFKB1 Antibodies)-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A (show PPP2R4 Antibodies)
NIK(+) endothelial cells may play an important role in the persistence of synovitis
Data suggest microRNA302c, but not microRNA520e, promotes replication of influenza A virus H3N2 although the two microRNAs target same site of NFkappaB (show NFKB1 Antibodies)-inducing kinase (MAP3K14) 3prime untranslated region; studies were conducted in lung epithelial cells.
TWEAK (show TNFSF12 Antibodies) induces noncanonical NF-kappaB (show NFKB1 Antibodies) signaling and signal-specific regulation of NIK mRNA expression.
constitutive activation of NIK (show MAP4K4 Antibodies) in the hematopoietic system leads to bone marrow (BM) failure and postnatal lethality.
results suggest that changes in the relative concentrations of RelB (show RELB Antibodies), NIK:IKK1, and p100 (show PATL2 Antibodies) during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100 (show PATL2 Antibodies).
NIK (show MAP4K4 Antibodies) pathways in both hepatocytes and immune cells act in concert to promote liver steatosis and glucose production in the setting of obesity.
this study demonstrates that although NIK (show MAP4K4 Antibodies) is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells
Using a novel conditional mutant of NIK (show MAP4K4 Antibodies), the authors could show in vivo that NIK (show MAP4K4 Antibodies) signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production.
NIK (show MAP4K4 Antibodies) not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1 (show TNFRSF1A Antibodies)/RIP1 (show RALBP1 Antibodies)-dependent cell death independently of the alternative NF-kappaB (show NFKB1 Antibodies) pathway.
This study demonstrated that NFkappaB-inducing kinase inhibits NFkappaB activity specifically in neurons of the CNS.
results assign NIK (show MAP4K4 Antibodies)-induced alternative NF-kappaB (show NFKB1 Antibodies) signaling a master regulatory role in B-cells, starting from the T1 stage and also show that B-1 B cells are less dependent on this pathway, presumably owing to the existence of alternative pathways yet to be determined
NIK (show MAP4K4 Antibodies), and thus probably the noncanonical NF-kappaB (show NFKB1 Antibodies) pathway, is critical to allow DCs to acquire the capacity to cross-present antigen and prime CD8 (show CD8A Antibodies) T cells after exposure to licensing stimuli.
Deletion of NIK (show MAP4K4 Antibodies) in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF (show TNFSF13B Antibodies).
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
, serine/threonine protein-kinase
, serine/threonine-protein kinase NIK
, NF kappa B-inducing kinase
, Nfkb inducing kinase
, protein kinase
, mitogen-activated protein kinase kinase kinase 14