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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||4 Antibodies|
|Flow Cytometry (FACS)||41 Antibodies|
|Functional Studies (Func)||2 Antibodies|
|Immunocytochemistry (ICC)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||23 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||26 Antibodies|
|Immunoprecipitation (IP)||19 Antibodies|
|Western Blotting (WB)||70 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) Antibodies|
|Epitope||AA 603-613 Alternatives|
|Conjugate||This TNFRSF11A antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-TNFRSF11A AntibodyTarget Details TNFRSF11A Application Details Handling Images
|Specificity||This antibody recognizes CD265/RANK.|
Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
|Purification||Protein G Chromatography.|
|Immunogen||KLH conjugated synthetic peptide corresponding to Amino acids residues 603-613 of Human RANK.|
Target Details TNFRSF11AProduct Details anti-TNFRSF11A Antibody Application Details Handling Images back to top
|Alternative Name||CD265 / RANK (TNFRSF11A Antibody Abstract)|
|Background||RANK is a member of the tumor necrosis factor receptor (TNFR) family. Human and murine RANK share 81 % amino acid identity in their extracellular domains. RANK is widely expressed, with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. RANK is also expressed in dendritic cells. RANK and RANK ligand (RANKL) are important regulators of interactions between T cells and dendritic cells. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of RANK. TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated by RANK include activation of NFkappaB and cjun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis. The soluble form of RANK is able to block TRANCE induced biological activity. The binding of anti-RANK to cell surface RANK triggers signal transduction and induces RANK mediated bioactivity.Synonyms: ODFR, Osteoclast differentiation factor receptor, Receptor activator of NF-KB, TNFRSF11A, Tumor necrosis factor receptor superfamily member 11A|
|Molecular Weight||66 kDa.|
Application DetailsProduct Details anti-TNFRSF11A Antibody Target Details TNFRSF11A Handling Images back to top
Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western blot: 1-3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF11A Antibody Target Details TNFRSF11A Application Details Images back to top
|Buffer||PBS containing 0.2 % Gelatin as stabilizer and 0.05 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
ImagesProduct Details anti-TNFRSF11A Antibody Target Details TNFRSF11A Application Details Handling back to top