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anti-Human GSK3 alpha antibody for Enzyme Immunoassay

Recommended GSK3 alpha Antibody (supplied by: Log in to see )

Antigen
Glycogen Synthase Kinase 3 alpha (GSK3a) Antibodies
  • 2700086H06Rik
  • CG5182
  • Dmel\\CG5182
  • GSK-3[a]
  • GSK-3[b]
  • GSK3
  • GSK3A
  • GSK3a
  • gsk3a
  • xgsk3
Epitope
C-Term
65
45
28
13
9
9
8
6
6
5
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
273
124
96
6
2
2
2
2
1
1
Host
Rabbit
211
92
3
Clonality
Polyclonal
Conjugate
This GSK3 alpha antibody is un-conjugated
20
11
10
7
6
6
4
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
250
130
123
50
40
30
26
11
5
4
3
1
Supplier
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Catalog No. ABIN360595
$ 401.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008867729 ABIN117908 EIA WB Rabbit AA 16-25, pSer21 Log in to see Polyclonal 5
0.0008867729 ABIN264482 EIA IP WB Mouse IgG2a Log in to see 2
0.0008867729 ABIN265449 EIA IHC (p) IP WB Rabbit Log in to see Polyclonal
0.0008867729 ABIN126804 EIA WB Mouse IgG1 pSer21 Log in to see 9B8
0.0008867729 ABIN117907 EIA WB Rabbit AA 16-25 Log in to see Polyclonal

Top referenced anti-GSK3 alpha antibody for Enzyme Immunoassay

  • Human Polyclonal GSK3 alpha Primary Antibody for EIA, WB - ABIN117908 (5 Publications): Wang, He, Wang, Wang, Zhai, Zhou, Zhang, Zhai, Feng, Han: [Impact of Donor KIR2DS5 Genotype on Outcome Following Haploidentical Hematopoietic Stem Cell Transplantation.] in Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology 2008 (PubMed)

  • Human Monoclonal GSK3 alpha Primary Antibody for EIA, IP - ABIN264482 (2 Publications): Kitaura, Asai, Maeda-Yamamoto, Kawakami, Kikkawa, Kawakami: Akt-dependent cytokine production in mast cells. in The Journal of experimental medicine 2000 (PubMed)

  • Human Polyclonal GSK3 alpha Primary Antibody for EIA, IHC (p) - ABIN360595 (1 Publications): Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)

Similar anti-GSK3 alpha Antibodies

Application / Reactivity Human
ELISA 107 Antibodies
Enzyme Immunoassay (EIA) 6 Antibodies
Flow Cytometry (FACS) 1 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunocytochemistry (ICC) 23 Antibodies
Immunofluorescence (IF) 50 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 107 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 27 Antibodies
Immunoprecipitation (IP) 39 Antibodies
Western Blotting (WB) 225 Antibodies

General

Antigen Glycogen Synthase Kinase 3 alpha (GSK3a) Antibodies
Epitope C-Term
(65), (45), (28), (13), (9), (9), (8), (6), (6), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(273), (124), (96), (6), (2), (2), (2), (2), (1), (1)
Host Rabbit
(211), (92), (3)
Clonality
Polyclonal
Conjugate This GSK3 alpha antibody is un-conjugated
(20), (11), (10), (7), (6), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(250), (130), (123), (50), (40), (30), (26), (11), (5), (4), (3), (1)
Pubmed 1 reference available
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Product Details anti-GSK3 alpha Antibody

Target Details GSK3 alpha Application Details Handling References for anti-GSK3 alpha Antibody (ABIN360595) Images
Specificity This antibody reacts to GSK3A.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human GSK3A.
Isotype Ig

Target Details GSK3 alpha

Product Details anti-GSK3 alpha Antibody Application Details Handling References for anti-GSK3 alpha Antibody (ABIN360595) Images back to top
Antigen
Alternative Name GSK3 alpha (GSK3a Antibody Abstract)
Background Glycogen synthase kinase 3-alpha (GSK3A)is a multifunctional protein serine kinase implicated in the control of several regulatory proteins including glycogen synthase and transcription factors. It also plays a role in the WNT and PI3K signaling pathways.1 Under resting conditions GSK3A and its homologs are highly phosphorylated at tyr279 in the phosphorylation loop.2 Constitutive phosphorylation of this tyrosine is important for kinase activity. Dephosphorylation of tyr279 after mitogen activation is accompanied by kinase inactivation. PKA as well as PI3K-activated PKB inactivate GSK3A by phosphorylation at ser21.3 Lysophosphatidic acid primarily utilizes a PKC-dependent pathway to modulate GSK3 and certain growth factors (e.g., PDGFB), which control GSK3 mainly through PIK3-PKB, are able to regulate GSK3 through an alternative, redundant phospholipase-C-gamma-PKC pathway.4 Alzheimer disease (AD) is associated with increased production and aggregation of amyloid-beta-40 and -42 peptides into plaques. GSK3A is required for maximal production of the beta-amyloid-40 and -42 peptides generated from the amyloid precursor protein (APP) by presenilin (PSEN1)-dependent gamma-secretase cleavage.5 In vitro, lithium, a GSK3A inhibitor, blocked the production of the beta-amyloid peptides by interfering with the gamma-secretase step. In mice expressing familial AD-associated mutations in APP and PSEN1, lithium reduced the levels of beta-amyloid peptides GSK3A also phosphorylates the tau protein (MAPT), the principal component of neurofibrillary tangles in AD, and suggested that inhibition of GSK3A may offer a new therapeutic approach to AD.Synonyms: Factor A, GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha
Gene ID 2931, 9606
UniProt P49840
Research Area Cardiovascular, Hypertrophy, Atherosclerosis, Wnt, Kinases/Phosphatases, Wnt Signaling
Pathways PI3K-Akt Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-GSK3 alpha Antibody Target Details GSK3 alpha Handling References for anti-GSK3 alpha Antibody (ABIN360595) Images back to top
Application Notes ELISA: 1/1,000. Western Blot: 1/100 - 1/500.
Restrictions For Research Use only

Handling

Product Details anti-GSK3 alpha Antibody Target Details GSK3 alpha Application Details References for anti-GSK3 alpha Antibody (ABIN360595) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-GSK3 alpha Antibody (ABIN360595)

Product Details anti-GSK3 alpha Antibody Target Details GSK3 alpha Application Details Handling Images back to top
Background publications

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002

Images

Product Details anti-GSK3 alpha Antibody Target Details GSK3 alpha Application Details Handling References for anti-GSK3 alpha Antibody (ABIN360595) back to top
Supplier Images
 image for anti-GSK3 alpha antibody (Glycogen Synthase Kinase 3 alpha) (C-Term) (ABIN360595) anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (C-Term) antibody
 image for anti-GSK3 alpha antibody (Glycogen Synthase Kinase 3 alpha) (C-Term) (ABIN360595) anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (C-Term) antibody (Image 2)