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|Application / Reactivity||Human|
|Dot Blot (DB)||120 Antibodies|
|ELISA (Capture)||1 Antibodies|
|Enzyme Immunoassay (EIA)||7 Antibodies|
|Flow Cytometry (FACS)||2 Antibodies|
|Immunochromatography (IC)||4 Antibodies|
|Immunocytochemistry (ICC)||11 Antibodies|
|Immunofluorescence (IF)||46 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||104 Antibodies|
|Immunohistochemistry (IHC)||135 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||64 Antibodies|
|Immunoprecipitation (IP)||6 Antibodies|
|Western Blotting (WB)||201 Antibodies|
|Antigen||Tuberous Sclerosis 2 (TSC2) Antibodies|
|Conjugate||This TSC2 antibody is un-conjugated Alternatives|
Dot Blot (DB), Immunofluorescence (IF)
|6 references available|
|Supplier||Log in to see|
Product Details anti-TSC2 AntibodyTarget Details TSC2 Application Details Handling References for anti-TSC2 Antibody (ABIN1881949) Images
|Predicted Reactivity||Mouse (Murine),Rat (Rattus)|
|Purification||This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Immunogen||This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1387 of human TSC2.|
Target Details TSC2Product Details anti-TSC2 Antibody Application Details Handling References for anti-TSC2 Antibody (ABIN1881949) Images back to top
|Alternative Name||TSC2 (TSC2 Antibody Abstract)|
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Synonyms: TSC2, TSC4, Tuberin, Tuberous sclerosis 2 protein
|NCBI Accession||NP_000539, NP_001070651, NP_001107854|
|Pathways||RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-TSC2 Antibody Target Details TSC2 Handling References for anti-TSC2 Antibody (ABIN1881949) Images back to top
|Application Notes||DB: 1:500,IF: 1:10-50|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TSC2 Antibody Target Details TSC2 Application Details References for anti-TSC2 Antibody (ABIN1881949) Images back to top
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
References for anti-TSC2 Antibody (ABIN1881949)Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling Images back to top
|Product cited in:||
Huang, Ratovitski: "Phospho-?Np63?/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells." in: Aging, Vol. 2, Issue 12, pp. 959-68, 2011 (PubMed).
Li, Inoki, Guan: "Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity." in: Molecular and cellular biology, Vol. 24, Issue 18, pp. 7965-75, 2004 (PubMed).
Corradetti, Inoki, Bardeesy et al.: "Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome." in: Genes & development, Vol. 18, Issue 13, pp. 1533-8, 2004 (PubMed).
Karbowniczek, Cash, Cheung et al.: "Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent." in: The Journal of biological chemistry, Vol. 279, Issue 29, pp. 29930-7, 2004 (PubMed).
Birchenall-Roberts, Fu, Bang et al.: "Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways." in: The Journal of biological chemistry, Vol. 279, Issue 24, pp. 25605-13, 2004 (PubMed).
Lewis, Thomas, Murphy et al.: "Genotype and psychological phenotype in tuberous sclerosis." in: Journal of medical genetics, Vol. 41, Issue 3, pp. 203-7, 2004 (PubMed).
ImagesProduct Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling References for anti-TSC2 Antibody (ABIN1881949) back to top